Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options
CDC Home

Isopropyl acetate

May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)

CAS number: 108–21–4

NIOSH REL: The 1989 OSHA PEL may not be protective to workers.

Current OSHA PEL: 250 ppm (950 mg/m3) TWA

1989 OSHA PEL: 250 ppm (950 mg/m3) TWA, 310 ppm (1,185 mg/m3) STEL

1993-1994 ACGIH TLV: 250 ppm (1,040 mg/m3) TWA, 310 ppm (1,290 mg/m3) STEL

Description of substance: Colorless liquid with a fruity odor.

LEL(@100°F): 1.8% (10% LEL(@100°F), 1,800 ppm)

Original (SCP) IDLH: 16,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the UCC [1970] report that a 4-hour exposure to 16,000 ppm killed 1 of 6 rats.

Short-term exposure guidelines: None developed


Lethal concentration data:





TimeAdjusted 0.5-hr


Derived value



Pozzani et al. 1959

Smyth et al. 1954

Smyth et al. 1954


LC83: 32,000

LC17: 16,000




8 hr

4 hr

4 hr

29,795 ppm (2.5)

64,000 ppm (2.0)

32,000 ppm (2.0)

2,980 ppm

6,400 ppm

3,200 ppm

Other animal data: It has been stated that isopropyl acetate is comparable in toxicity to ethyl acetate and n-propyl acetate [ACGIH 1991].

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 1,800 ppm

Basis for revised IDLH: The revised IDLH for isopropyl acetate is 1,800 ppm based on analogies to ethyl acetate and n-propyl acetate [ACGIH 1991]. This value is also 10% of the lower explosive limit of 1.8% (which was determined at 100°F).


1. ACGIH [1991]. Isopropyl acetate. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 826-827.

2. Pozzani UC, Weil CS, Carpenter CP [1959]. The toxicological basis of threshold limit values: 5. The experimental inhalation of vapor mixtures by rats, with notes upon the relationship between single dose inhalation and single dose oral data. Am Ind Hyg Assoc J 20:364-369.

3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC [1954]. Range-finding toxicity data: list V. AMA Arch Ind Hyg Occup Med 10:61-68.

4. UCC [1970]. Toxicology studies: isopropyl acetate. New York, NY: Union Carbide Corporation.

Contact Us:
  • Page last reviewed: December 4, 2014
  • Page last updated: December 4, 2014 The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30329-4027, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC-INFO