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May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


Ethylenediamine

CAS number: 107–15–3

NIOSH REL: 10 ppm (25 mg/m3) TWA

Current OSHA PEL: 10 ppm (25 mg/m3) TWA

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 10 ppm (25 mg/m3) TWA [skin]

Description of Substance: Colorless, viscous liquid with an ammonia-like odor.

LEL(@12 F): 2.5% (10% LEL(@12 F), 2,500 ppm)

Original (SCP) IDLH: 2,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by AIHA [1970] that an 8-hour exposure to 4,000 ppm killed 6 of 6 rats, but that an 8-hour exposure to 2,000 ppm killed 0 of 6 rats [Smyth et al. 1951]. Further support for the chosen IDLH is gained from the statement by UCC [1971] that humans will not stay in concentrations of 2,000 ppm.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

 


Species

Reference
LC50

(ppm)

LCLo

(ppm)


Time
Adjusted 0.5-hr

LC (CF)

Derived

value

RatSmyth et a. 1951LC100: 4,000 -----8 hr10,000 ppm (2.5)1,000 ppm


Lethal dose data:

 


Species

Reference

Route
LD50

(mg/kg)

LDLo

(mg/kg)


Adjusted LD

Derived value
Rat

G. pig

Rat

Izmerov et al. 1982

Smyth et al. 1941

Smyth et al. 1951

oral

oral

oral

500

470

1,160

-----

-----

-----

1,400 ppm

1,316 ppm

3,248 ppm

140 ppm

132 ppm

325 ppm


Other animal data: It has been reported that rats have survived an 8-hour exposure to 2,000 ppm [Smyth et al. 1951].

Human data: It has been reported that workers will not stay in concentrations of 2,000 ppm [UCC 1971].

 

Revised IDLH: 1,000 ppm

Basis for revised IDLH: The revised IDLH for ethylenediamine is 1,000 ppm based on acute inhalation toxicity data in animals [Smyth et al. 1951]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations between 1,000 and 2,000 ppm.


REFERENCES:

1. AIHA [1970]. Ethylene diamine. In: Hygienic guide series. Am Ind Hyg Assoc J 31:113-115.

2. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 66.

3. Smyth HF, Seaton J, Fischer L [1941]. The single dose toxicity of some glycols and derivatives. J Ind Hyg Toxicol 23(6):259-268.

4. Smyth HF Jr, Carpenter CP, Weil CS [1951]. Range-finding toxicity data: list IV. AMA Arch Ind Hyg Occup Med 4:119-122.

5. UCC [1971]. Toxicology studies: ethylene diamine. New York, NY: Union Carbide Corporation.

 
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