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May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


Quinone

CAS number: 106–51–4

NIOSH REL: 0.4 mg/m3 (0.1 ppm) TWA

Current OSHA PEL: 0.4 mg/m3 (0.1 ppm) TWA

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 0.44 mg/m3 (0.1 ppm) TWA

Description of substance: Pale-yellow solid with an acrid, chlorine-like odor.

LEL: . . . Unknown

Original (SCP) IDLH: 300 mg/m3

Basis for original (SCP) IDLH: The chosen IDLH is based on the mouse LCLO of 320 mg/m3 [Zabolevanii 1962 cited by NIOSH 1976]. No other data on acute inhalation toxicity are available on which to base the IDLH.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal dose data:

 

SpeciesReferenceRouteLD50

(mg/kg)

LDLo

(mg/kg)

Adjusted LDDerived value
Mammal

Mouse

Mouse

Rat

Rat

Rat

Izmerov et al. 1982

Marquardt et al. 1947

Serif & Seymour 1963

Tomchin et al. 1978

Woodward et al. 1949

Woodward et al. 1949

s.c.

s.c.

i.p.

?

oral

i.v.

296

93.8

8.5

5.6

130

25

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-----

-----

-----

-----

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2,072 mg/m3

657 mg/m3

60 mg/m3

39 mg/m3

910 mg/m3

175 mg/m3

207 mg/m3

66 mg/m3

6.0 mg/m3

3.9 mg/m3

91 mg/m3

18 mg/m3

Human data: None relevant for use in determining the revised IDLH.

 

Revised IDLH: 100 mg/m3

Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for quinone. Therefore, the revised IDLH for quinone is 100 mg/m3 based on acute oral toxicity data in animals [Woodward et al. 1949]. This may be a conservative value due to the lack of relevant acute toxicity data for workers.

REFERENCES:

1. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 25.

2. Marquardt P, Koch R, Aubert J-P [1947]. Die toxizität der ein-, zwei- und dreiwertigen phenole. Zeit Ges Med Gren 2:333 (in German).

3. NIOSH [1976]. DK26250. p-Benzoquinone. In: Registry of toxic effects of chemical substances, 1976 ed. Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-191, p. 202.

4. Serif GS, Seymour LE [1963]. Catabolism and excretion of the antithyroid substance, diacetyl-2,6-diiodohydroquinone. Biochem Pharmacol 12:885-891.

5. Tomchin AB, Aleksandrova AE, Vinogradov VM [1978]. Structure and anti-hypoxic activity of alpha-dicarbonyl compounds and their derivatives. Farmakol Toxsikol 41(4):482-491 (in Russian).

6. Woodward G, Hagan EC, Radomski JL [1949]. Toxicity of hydroquinone for laboratory animals. Fed Proc 8:348.

7. Zabolevanii Prof. Khim. Etiol. Sb. [1962]. Prom Toksikol Klin, p. 137 (in Russian). [From NIOSH [1976]. DK26250. p-Benzoquinone. In: Registry of toxic effects of chemical substances, 1976 ed. Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-191, p. 202.]

 
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