CAS number: 106–51–4
NIOSH REL: 0.4 mg/m3 (0.1 ppm) TWA
Current OSHA PEL: 0.4 mg/m3 (0.1 ppm) TWA
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 0.44 mg/m3 (0.1 ppm) TWA
Description of substance: Pale-yellow solid with an acrid, chlorine-like odor.
LEL: . . . Unknown
Original (SCP) IDLH: 300 mg/m3
Basis for original (SCP) IDLH: The chosen IDLH is based on the mouse LCLO of 320 mg/m3 [Zabolevanii 1962 cited by NIOSH 1976]. No other data on acute inhalation toxicity are available on which to base the IDLH.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal dose data:
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| Mammal
Mouse Mouse Rat Rat Rat | Izmerov et al. 1982 Marquardt et al. 1947 Serif & Seymour 1963 Tomchin et al. 1978 Woodward et al. 1949 Woodward et al. 1949 |
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Human data: None relevant for use in determining the revised
IDLH.
| Revised IDLH: 100 mg/m3
Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for quinone. Therefore, the revised IDLH for quinone is 100 mg/m3 based on acute oral toxicity data in animals [Woodward et al. 1949]. This may be a conservative value due to the lack of relevant acute toxicity data for workers. |
REFERENCES:
1. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 25.
2. Marquardt P, Koch R, Aubert J-P [1947]. Die toxizität der ein-, zwei- und dreiwertigen phenole. Zeit Ges Med Gren 2:333 (in German).
3. NIOSH [1976]. DK26250. p-Benzoquinone. In: Registry of toxic effects of chemical substances, 1976 ed. Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-191, p. 202.
4. Serif GS, Seymour LE [1963]. Catabolism and excretion of the antithyroid substance, diacetyl-2,6-diiodohydroquinone. Biochem Pharmacol 12:885-891.
5. Tomchin AB, Aleksandrova AE, Vinogradov VM [1978]. Structure and anti-hypoxic activity of alpha-dicarbonyl compounds and their derivatives. Farmakol Toxsikol 41(4):482-491 (in Russian).
6. Woodward G, Hagan EC, Radomski JL [1949]. Toxicity of hydroquinone for laboratory animals. Fed Proc 8:348.
7. Zabolevanii Prof. Khim. Etiol. Sb. [1962]. Prom Toksikol Klin, p. 137 (in Russian). [From NIOSH [1976]. DK26250. p-Benzoquinone. In: Registry of toxic effects of chemical substances, 1976 ed. Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-191, p. 202.]
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