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NIOSH draft method 8324: 3-Bromopropionic acid in urine; A metabolite of 1-bromopropane

June 2014
NIOSH Docket Number 273, CDC-2014-0006

The National Institute for Occupational Safety and Health (NIOSH) of the Centers for Disease Control and Prevention (CDC) intends to publish a new method in the NIOSH Manual of Analytical Methods (NMAM). This method is entitled "Method 8324: 3-Bromopropionic acid in urine; A metabolite of 1-bromopropane."

1-Bromopropane is an industrial solvent often used as a substitute for a number of chlorofluorocarbon solvents which have been withdrawn from use because of their possible damaging effects to the ozone layer. 3-Bromopropionic acid is a human metabolite of 1-bromopropane and a proposed biomarker of exposure. An accurate and precise method was developed for the detection and quantitation of 3-bromopropionic acid in human urine. This method has been published in the literature (B'Hymer CB, Cheever KL [2004]. J Chromatogr B 802:361-366). The method has been further validated by a second laboratory and is proposed for inclusion in NMAM's 5th Edition.

NIOSH did not receive any submissions to this request.

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Background Information

Federal Register Notice: Federal Register Notice

Draft method and its associated backup data report, including data from the second laboratory validation

NMAM Report