After exposure to Hepatitis B virus (HBV), appropriate and timely prophylaxis can prevent HBV infection and subsequent development of chronic infection or liver disease. The mainstay of postexposure prophylaxis (PEP) is Hepatitis B vaccine, but, in certain circumstances, Hepatitis B immune globulin is recommended in addition to vaccine for added protection. This page provides links to PEP guidelines and resources by type of exposure.
Clinicians Post-Exposure Prophylaxis Hotline (PEPline)
Hotline providing clinicians with 24-hour guidance on managing occupational exposures to HIV, viral hepatitis, and other bloodborne pathogens
Postexposure Prophylaxis to Prevent Hepatitis B Virus Infection
MMWR 2006,56(RR-16), Appendix B
Infants born to HBV-infected mothers should receive Hepatitis B vaccine and Hepatitis B immune globulin within 12 hours of birth.
See the Perinatal Transmission page or the complete guidelines on postexposure prophylaxis for newborns: A Comprehensive Immunization Strategy to Eliminate Transmission of Hepatitis B Virus Infection: Recommendations of the Advisory Committee on Immunization Practices. Part 1: Immunization of Infants, Children, and Adolescents [PDF - 39 pages]