Methyl acrylate
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 96–33–3
NIOSH REL: 10 ppm (35 mg/m3) TWA [skin]
Current OSHA PEL: 10 ppm (35 mg/m3) TWA [skin]
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 10 ppm (35 mg/m3) TWA [skin]
Description of substance: Colorless liquid with an acrid odor.
LEL: . . 2.8% (10% LEL, 2,800 ppm)
Original (SCP) IDLH: 1,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the rat 4-hour LC50 of 1,000 ppm in which 3 of 6 rats died [Smyth and Carpenter 1948 cited by Patty 1963].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
| Species | Reference | LC50 (ppm) |
LCLo (ppm) |
Time | Adjusted 0.5-hr LC (CF) |
Derived value |
| Mouse Rat Rat Rabbit |
Lomonova & Klimova 1979 Oberly &Tansey 1985 Smyth &Carpenter 1948 Treon et al. 1949 |
3,575 1,350 1,000 2,522 |
----- ----- ----- ----- |
? 4 hr 4 hr 1 hr |
? 2,700 ppm (2.0) 2,000 ppm (2.0) 3,153 ppm (1.25) |
? 270 ppm 200 ppm 315 ppm |
Other animal data: Rats exposed 4 hours per day, 5 days per week at 110 ppm for a total of 32 exposures had eye discomfort at the start of the investigation, but no overt signs of respiratory distress or other manifestations of toxicity were recorded [Oberly and Tansey 1985].
Human data: None relevant for use in determining the revised IDLH.
| Revised IDLH: 250 ppm Basis for revised IDLH: The revised IDLH for methyl acrylate is 250 ppm based on acute inhalation data in animals [Oberly and Tansey 1985; Smyth and Carpenter 1948; Treon et al. 1949]. |
REFERENCES:
1. Lomonova GV, Klimova EI [1979]. On the toxicity methyl and ethyl acrylates. Gig Tr Prof Zabol 23(9):55-56 (in Russian).
2. Oberly R, Tansey MF [1985]. LC50 values for rats acutely exposed to vapors of acrylic and methacrylic acid esters. J Toxicol Environ Health 16:811-822.
3. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1880.
4. Smyth HF Jr, Carpenter CP [1948]. Further experience with the range-finding test in the industrial toxicology laboratory. J Ind Hyg Toxicol 30:63-68.
5. Treon JF, Sigmon H, Wright H, Kitzmiller KV [1949]. The toxicity of methyl and ethyl acrylate. J Ind Hyg Toxicol 31:317-326.