n-Amyl acetate
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 628-63-7
NIOSH REL: 100 ppm (525 mg/m3) TWA
Current OSHA PEL: 100 ppm (525 mg/m3) TWA
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 100 ppm (532 mg/m3) TWA
Description of substance: Colorless liquid with a persistent banana-like odor.
LEL: 1.1% (10% LEL, 1,100 ppm)
Original (SCP) IDLH: 4,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by Browning [1965] that exposure to 4,000 ppm of a mixture of n-amyl acetate and isoamyl acetate produced complete loss of reflexes in rabbits within an hour [Koelsch 1912], and on the statement by Sax [1975] that 5,000 ppm n-amyl acetate produced deep narcosis in cats in 30 minutes.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
| Adjusted | ||||||
|---|---|---|---|---|---|---|
| LC50 | LCLo | 0.5-hr | Derived | |||
| Species | Reference | (ppm) | (ppm) | Time | LC (CF) | Value |
| Rat | NPIRI 1974 | ----- | 5,200 | ? | ? | ? |
Lethal dose data:
| LD50 | LDLo | Derived | ||||
|---|---|---|---|---|---|---|
| Species | Reference | Route | (Mg/kg) | (mg/kg) | Adjusted LD | Value |
| Rabbit | Marhold 1986 | oral | 7,400 | ----- | 9,575 ppm | 958 ppm |
| Rat | NPIRI 1974 | oral | 6,500 | ----- | 8,410 ppm | 841 ppm |
Other animal data: RD50 (mouse), 1,531 ppm [Alarie 1981].
Human data: Somnolence has been reported after exposure to 952 ppm for 30 minutes [Lehmann 1913].
Revised IDLH: 1,000 ppm Basis for revised IDLH: The revised IDLH for n-amyl acetate is 1,000 ppm based on acute toxicity data in humans [Lehmann 1913] and animals [Alarie 1981; Marhold 1986]. |
References:
- Alarie Y [1981]. Dose-response analysis in animal studies: prediction of human responses. Environ Health Perspect 42:9-13.
- Browning E [1965]. Toxicity and metabolism of industrial solvents. New York, NY: Elsevier Publishing Company, p. 539.
- Koelsch [1912]. Damage to health by amyl acetate. Concordia No. 12.
- Lehmann KB [1913]. Experimentelle studien uber den einflufs technisch wichtiger gase und dampfe auf den organimus (XXXII/XXXIII). Amylazetat und cyclohexanolazetat. Arch Hyg 78:260-273 (in German).
- Marhold J [1986]. Prehled prumyslove toxikologie: organicke latky. Prague, Czechoslovakia: Avicenum, p. 357 (in Czechoslovakian).
- NPIRI [1974]. Raw materials data handbook, physical and chemical properties, fire hazard and health hazard data. Vol. 1. Organic solvents. Bethlehem, PA: National Printing Ink Research Institute, p. 3.
- Sax NI [1975]. Dangerous properties of industrial materials. 4th ed. New York, NY: Van Nostrand Reinhold Company, Inc., p. 398.