TEDP
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 3689–24–5
NIOSH REL: 0.2 mg/m3 TWA [skin]
Current OSHA PEL: 0.2 mg/m3 TWA [skin]
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 0.2 mg/m3 TWA [skin]
Description of substance: Pale-yellow liquid with a garlic-like odor.
LEL :. . Unknown
Original (SCP) IDLH: 35 mg/m3
Basis for original (SCP) IDLH: The chosen IDLH is based on the rat oral LD50 of 5 mg/kg [Lehman 1951 cited by ACGIH 1971]. No other useful data are available on which to base the IDLH.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
| Species | Reference | LC50 | LCLo | Time | Adjusted 0.5-hr LC (CF) |
Derived value |
| Rat | Kimmerle & Klimmer 1974 | 38 mg/m3 | ----- | 4 hr | 76 mg/m3 (2.0) | 7.6 mg/m3 |
| Mouse | Kimmerle & Klimmer 1974 | 40 mg/m3 | ----- | 4 hr | 80 mg/m3 (2.0) | 8.0 mg/m3 |
Lethal dose data:
| Species | Reference | Route | LD50 (mg/kg) |
LDLo (mg/kg) |
Adjusted LD | Derived value |
| Mouse | Kimmerle & Klimmer 1974 | oral | 22 | ----- | 154 mg/m3 | 15 mg/m3 |
| Rabbit | Kimmerle &Klimmer 1974 | oral | 25 | ----- | 175 mg/m3 | 18 mg/m3 |
| Dog | Kimmerle & Klimmer 1974 | oral | 5 | ----- | 35 mg/m3 | 3.5 mg/m3 |
| Rat | Lehman 1951 | oral | 5 | ----- | 35 mg/m3 | 3.5 mg/m3 |
Other animal data: It has been stated that TEDP is an organophosphate pesticide whose toxicity is similar to that of parathion [ACGIH 1991].
Human data: None relevant for use in determining the revised IDLH.
| Revised IDLH: 10 mg/m3 Basis for revised IDLH: The revised IDLH for TEDP is 10 mg/m3 based on acute inhalation toxicity data in animals [Kimmerle and Klimmer 1974] and on an analogy with parathion [ACGIH 1991] which has a revised IDLH of 10 mg/m3. |
REFERENCES:
1. ACGIH [1971]. TEDP (tetraethyl dithionopyrophosphate). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 244-245.
2. ACGIH [1991]. Sulfotep. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1452-1454.
3. Kimmerle G, Klimmer OR [1974]. Acute and subchronic toxicity of sulfotep. Arch Toxicol 33:1-16.
4. Lehman AJ [1951]. Chemicals in foods: A report to the Association of Food and Drug Officials on current developments. Part II. Pesticides. Section II. Dermal Toxicity. Q Bulletin Assoc Food Drug Off U.S. 16(1):3-9.