Quinone

CAS number: 106–51–4

NIOSH REL: 0.4 mg/m³ (0.1 ppm) TWA

Current OSHA PEL: 0.4 mg/m³ (0.1 ppm) TWA

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 0.44 mg/m³ (0.1 ppm) TWA

Description of substance: Pale-yellow solid with an acrid, chlorine-like odor.

LEL: . . . Unknown

Original (SCP) IDLH: 300 mg/m³

Basis for original (SCP) IDLH: The chosen IDLH is based on the mouse LC_LO of 320 mg/m³ [Zabolevanii 1962 cited by NIOSH 1976]. No other data on acute inhalation toxicity are available on which to base the IDLH.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal dose data:

Species	Reference	Route	LD50 (mg/kg)	LDLo (mg/kg)	Adjusted LD	Derived value
Mammal Mouse Mouse Rat Rat Rat	Izmerov et al. 1982 Marquardt et al. 1947 Serif & Seymour 1963 Tomchin et al. 1978 Woodward et al. 1949 Woodward et al. 1949	s.c. s.c. i.p. ? oral i.v.	296 93.8 8.5 5.6 130 25	----- ----- ----- ----- ----- -----	2,072 mg/m3 657 mg/m3 60 mg/m3 39 mg/m3 910 mg/m3 175 mg/m3	207 mg/m3 66 mg/m3 6.0 mg/m3 3.9 mg/m3 91 mg/m3 18 mg/m3

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 100 mg/m3 Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for quinone. Therefore, the revised IDLH for quinone is 100 mg/m3 based on acute oral toxicity data in animals [Woodward et al. 1949]. This may be a conservative value due to the lack of relevant acute toxicity data for workers.

REFERENCES:

1. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 25.

2. Marquardt P, Koch R, Aubert J-P [1947]. Die toxizität der ein-, zwei- und dreiwertigen phenole. Zeit Ges Med Gren 2:333 (in German).

3. NIOSH [1976]. DK26250. p-Benzoquinone. In: Registry of toxic effects of chemical substances, 1976 ed. Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-191, p. 202.

4. Serif GS, Seymour LE [1963]. Catabolism and excretion of the antithyroid substance, diacetyl-2,6-diiodohydroquinone. Biochem Pharmacol 12:885-891.

5. Tomchin AB, Aleksandrova AE, Vinogradov VM [1978]. Structure and anti-hypoxic activity of alpha-dicarbonyl compounds and their derivatives. Farmakol Toxsikol 41(4):482-491 (in Russian).

6. Woodward G, Hagan EC, Radomski JL [1949]. Toxicity of hydroquinone for laboratory animals. Fed Proc 8:348.

7. Zabolevanii Prof. Khim. Etiol. Sb. [1962]. Prom Toksikol Klin, p. 137 (in Russian). [From NIOSH [1976]. DK26250. p-Benzoquinone. In: Registry of toxic effects of chemical substances, 1976 ed. Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-191, p. 202.]