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Volume 30, Number 3—March 2024
Dispatch

Highly Pathogenic Avian Influenza A(H5N1) Virus Clade 2.3.4.4b in Domestic Ducks, Indonesia, 2022

Hendra WibawaComments to Author , Putut Eko Wibowo, Arif Supriyadi, Lestari Lestari, Jessiaman Silaban, Aziz Ahmad Fuadi, Anna Januar Fiqri, Retno Wulan Handayani, Sri Handayani Irianingsih, Zaza Fahmia, Herdiyanto Mulyawan, Syafrison Idris, and Nuryani Zainuddin
Author affiliations: Disease Investigation Center Wates, Yogyakarta, Indonesia (H. Wibawa, Lestari, J. Silaban, S.H. Irianingsih, Z. Fahmia, H. Mulyawan); Disease Investigation Center Banjarbaru, Banjarbaru, Indonesia (P.E. Wibowo, A. Supriyadi, A.A. Fuadi, A.J. Fiqri, R.W. Handayani); Directorate General of Livestock and Animal Health Services, Jakarta, Indonesia (S. Idris, N. Zainuddin)

Main Article

Table 1

DNA sequence homologies between highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b viruses isolated from domestic ducks in Indonesia, 2022, and those from Banjarbaru and East Asia*

Virus name GISAID no.† Collection date % Nucleic acid similarity for each gene segment
PB2 PB1 PA HA NP NA MP NS
Viruses from first outbreak in Hulu Sungai Utara
EPI_ISL_17371282, EPI_ISL_17371283, EPI_ISL_17371284
 2022 Apr
 100
 100
 99.8–99.9
 99.9–100
 100
 100
 100
 99.8–100
A/Muscovy duck/Banjarbaru/A0523532-9/2023
 EPI_ISL_18438033
 2023 Jul 7
 99.4
 99.3–99.4
 99.1–99.2
 98.9–99.0
 99.1
 98.8
 99.8
 98.7
A/mandarin duck/Korea/WA585/2021
 EPI_ISL_6959592
 2021 Oct 26
 99.6
 99.5–99.6
 99.6–99.7
 99.2–99.3
 99.6
 99.8
 99.6
 99.4
A/quail/Korea/H526/2021
 EPI_ISL_6959593
 2021 Nov 8
 99.4
 99.2
 99.2–99.3
 99.0–99.1
 99.3
 99.6
 99.3
 99.2
A/duck/Guangdong/S4525/2021
 EPI_ISL_12572655
 2021 Dec 8
 99.6
 99.6
 99.3–99.4
 99.2–99.3
 99.5
 99.7
 99.7
 99.2
A/duck/Hubei/SE220/2022
 EPI_ISL_12572659
 2022 Jan 10
 99.6
 99.5
 99.3–99.4
 99.0–99.2
 99.5
 99.5
 99.6
 99.2
A/duck/Guizhou/S1321/2022
 EPI_ISL_12572656
 2022 Feb 22
 99.6
 99.6
 99.5–99.6
 97.2–97.3
 99.5
 99.4
 99.8
 99.2
A/chicken/Kagoshima/21A6T/2021
 EPI_ISL_6829533
 2021 Nov 12
 99.6
 99.6
 99.6–99.7
 99.1–99.2
 99.6
 99.7
 99.8
 99.4
A/chicken/Saitama/TU7-34,36/2021
 EPI_ISL_15063425
 2021 Dec 7
 99.6
 99.3–99.4
 99.1–99.2
 98.4–98.6
 99.1
 99.6
 99.3
 99.0
A/chicken/Ehime/TU11-2-24 25/2022
 EPI_ISL_15063431
 2022 Jan 4
 99.8
 92.0
 99.5–99.6
 99.2–99.3
 99.3
 99.6
 99.7
 99.3
A/common buzzard/Japan/2601B013/2022
EPI_ISL_16831015
 2022 Jan 27
 99.6
 99.2–99.3
 99.3–99.4
 98.6–98.7
 99.3
 99.6
 99.3
 99.2
A/teal/Miyazaki/211109-32/2021 EPI_ISL_15613494 2021 Nov 9 99.4 99.2–99.3 99.3 98.7–98.8 99.1 99.6 99.2 99.2

*H5N1 clade 2.3.4.4b viruses isolated from the initial poultry outbreak in Hulu Sungai Utara in April 2022 were compared with those isolated later from Banjarbaru, Indonesia, in July 2023 and H5N1 clade 2.3.4.b viruses from East Asia isolated during October 2021–February 2022. HA, hemagglutinin; MP, matrix protein; NA, neuraminidase; NP, nucleoprotein; NS, nonstructural; PA, polymerase acidic; PB1, polymerase basic 1; PB2, polymerase basic 2. †GISAID database (https://www.gisaid.org).

Main Article

Page created: January 08, 2024
Page updated: February 22, 2024
Page reviewed: February 22, 2024
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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