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Volume 29, Number 9—September 2023
Research

Interspecies Transmission of Swine Influenza A Viruses and Human Seasonal Vaccine-Mediated Protection Investigated in Ferret Model

Pauline M. van DiemenComments to Author , Alexander M.P. Byrne, Andrew M. Ramsay, Samantha Watson, Alejandro Nunez, Ana v Moreno, Chiara Chiapponi, Emanuela Foni, Ian H. Brown, Sharon M. Brookes, and Helen E. EverettComments to Author 
Author affiliations: Animal and Plant Health Agency, Addlestone, UK (P.M. van Diemen, A.M.P. Byrne, A.M. Ramsay, S. Watson, A. Nunez, I.H. Brown, S.M. Brookes, H.E. Everett); Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Brescia, Italy (C. Chiapponi, E. Foni, A. Moreno)

Main Article

Figure 5

Characterization of virus-specific humoral responses following intranasal inoculation of pigs with A/swine/England/1353/2009 (H1pdmN1, panels A, C, E) or A/Pavia/65/2016 (H1avN1, panels B, D, F). Antibody titers were monitored at 0, 5, and 14 dpi by nucleoprotein competitive ELISA (A, B) and are expressed as competition percentage and considered negative if <50% (gray area). Competition percentage was calculated as (1 – sample/negative) × 100. Hemagglutination inhibition (C, D) and virus neutralization (E, F) titers were assessed at 0 and 14 dpi using the homologous virus for each group. Both titers were normalized to the individual prevaccination titers (0 days postvaccination). dpi: days postinoculation

Figure 5. Characterization of virus-specific humoral responses following intranasal inoculation of pigs with A/swine/England/1353/2009 (H1pdmN1, panels A, C, E) or A/Pavia/65/2016 (H1avN1, panels B, D, F). Antibody titers were monitored at 0, 5, and 14 dpi by nucleoprotein competitive ELISA (A, B) and are expressed as competition percentage and considered negative if <50% (gray area). Competition percentage was calculated as (1 – sample/negative) × 100. Hemagglutination inhibition (C, D) and virus neutralization (E, F) titers were assessed at 0 and 14 dpi using the homologous virus for each group. Both titers were normalized to the individual prevaccination titers (0 days postvaccination). dpi: days postinoculation

Main Article

Page created: July 05, 2023
Page updated: August 20, 2023
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