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Volume 30, Number 5—May 2024
Research Letter

SARS-CoV-2 IgG Levels as Predictors of XBB Variant Neutralization, Israel, 2022­ and 2023

Yaniv LustigComments to Author , Michal Canetti, Victoria Indenbaum, Yovel Peretz, Yael Weiss-Ottolenghi, Ili Margalit, Keren Asraf, Tal Levin, Neta Zuckerman, Enosh Tomer, Michal Mandelboim, Ram Doolman, Noam Barda, and Gili Regev-Yochay
Author affiliations: Sheba Pandemic Research Institute, Ramat-Gan, Israel (Y. Lustig, M. Canetti, Y. Peretz, Y. Weiss-Ottolenghi, I. Margalit, N. Zuckerman, G. Regev-Yochay); Tel-Aviv University Faculty of Medical and Health Sciences, Tel Aviv, Israel (Y. Lustig, M. Canetti, I. Margalit, M. Mandelboim, G. Regev-Yochay); Central Virology Laboratory, Public Health Services, Ministry of Health, Ramat-Gan (Y. Lustig, V. Indenbaum, T. Levin, N. Zuckerman, E. Tomer, M. Mandelboim); The Dworman Automated-Mega Laboratory, Ramat-Gan (K. Asraf, R. Doolman); ARC Innovation Center, Ramat-Gan (N. Barda); Ben-Gurion University of the Negev, Be’er Sheva, Israel (N. Barda)

Main Article

Figure

Binding IgG and neutralizing titer levels from samples collected in 2022 and 2023 from patient participants at the Sheba Medical Center, Israel, and the prediction of SARS-CoV-2 Omicron XBB neutralization by RBD-WT IgG levels from those samples. A) Scatter plot analyses of 1,071 WT IgG and XBB-specific neutralizing titers in samples obtained from healthcare workers during 2022 and 2023. Horizontal lines indicate GMTs; error bars indicate 95% CIs. GMT of each timepoint is indicated. B) ROC curves showing the diagnostic value of WT IgG levels for high (titer >250) XBB-specific neutralization levels. Sensitivity and specificity determinants for specific cut off levels are shown. BAU, binding antibody unit; GMT, geometric mean titer; ID50, 50% inhibitory dilution; RBD, receptor-binding domain; ROC, receiver operating characteristic; WT, SARS-CoV-2 ancestral (wild-type) strain.

Figure. Binding IgG and neutralizing titer levels from samples collected in 2022 and 2023 from patient participants at the Sheba Medical Center, Israel, and the prediction of SARS-CoV-2 Omicron XBB neutralization by RBD-WT IgG levels from those samples. A) Scatter plot analyses of 1,071 WT IgG and XBB-specific neutralizing titers in samples obtained from healthcare workers during 2022 and 2023. Horizontal lines indicate GMTs; error bars indicate 95% CIs. GMT of each timepoint is indicated. B) ROC curves showing the diagnostic value of WT IgG levels for high (titer >250) XBB-specific neutralization levels. Sensitivity and specificity determinants for specific cut off levels are shown. BAU, binding antibody unit; GMT, geometric mean titer; ID50, 50% inhibitory dilution; RBD, receptor-binding domain; ROC, receiver operating characteristic; WT, SARS-CoV-2 ancestral (wild-type) strain.

Main Article

Page created: April 08, 2024
Page updated: April 24, 2024
Page reviewed: April 24, 2024
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