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Volume 28, Number 4—April 2022
Research Letter

Vaccine-Associated Measles Encephalitis in Immunocompromised Child, California, USA

Cristina Costales, Malaya K. Sahoo, ChunHong Huang, Carolina V. Guimaraes, Donald Born, Lauren Kushner, Hayley A. Gans, Thuy A. Doan, and Benjamin A. PinskyComments to Author 
Author affiliations: Stanford University School of Medicine, Stanford, California, USA (C. Costales, M.K. Sahoo, C. Huang, C.V. Guimaraes, D. Born, L. Kushner, H.A. Gans, B.A. Pinsky); Proctor Foundation, San Francisco, California, USA (T.A. Doan)

Main Article

Figure

Sequenced vaccine-strain measles virus matrix protein gene from a 1-year-old patient’s brain tissue, California, USA. Results show biased hypermutation of uracil-containing codons, with >1 U-to-C mutation at levels ≥5%, consistent with hypermutation of the matrix gene as found in central nervous system measles virus infections such as subacute sclerosing panencephalitis and measles inclusion body encephalitis. C, cytosine; U, uracil.

Figure. Sequenced vaccine-strain measles virus matrix protein gene from a 1-year-old patient’s brain tissue, California, USA. Results show biased hypermutation of uracil-containing codons, with >1 U-to-C mutation at levels ≥5%, consistent with hypermutation of the matrix gene as found in central nervous system measles virus infections such as subacute sclerosing panencephalitis and measles inclusion body encephalitis. C, cytosine; U, uracil.

Main Article

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Page updated: March 19, 2022
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