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Volume 24, Number 9—September 2018
Dispatch

Fatal Tickborne Phlebovirus Infection in Captive Cheetahs, Japan

Keita MatsunoComments to Author , Noriyuki Nonoue, Ayako Noda, Nodoka Kasajima, Keita Noguchi, Ai Takano, Hiroshi Shimoda, Yasuko Orba, Mieko Muramatsu, Yoshihiro Sakoda, Ayato Takada, Shinji Minami, Yumi Une, Shigeru Morikawa, and Ken Maeda
Author affiliations: Hokkaido University, Sapporo, Japan (K. Matsuno, Y. Sakoda, A. Takada); Hiroshima City Asa Zoological Park, Hiroshima, Japan (N. Nonoue, A. Noda, S. Minami); Hokkaido University Research Center for Zoonosis Control, Sapporo (N. Kasajima, Y. Orba, M. Muramatsu, A. Takada); Yamaguchi University, Yamaguchi, Japan (K. Noguchi, A. Takano, H. Shimoda, K. Maeda); Okayama University of Science, Imabari, Japan (Y. Une); National Institute of Infectious Diseases, Tokyo, Japan (S. Morikawa)

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Table

Hematology and blood chemistry parameters in 2 fatal cases of severe fever with thrombocytopenia syndrome in cheetahs, Japan, 2017

Laboratory value Normal (± SD)* Cheetah 1, day 3† Cheetah 2‡
Day 2 Day 3 Day 4 Day 6 Day 7§
Leukocytes/μL 10,350 (3,500) 1,700 12,500 10,700 6,900 3,900 4,800
Erythrocytes, × 103 cells/μL 684 (106) 707 845 756 834 722 952
Platelets, × 103/μL¶ 349 (119) 1 12.7 9.1 5.9 0.9 1.3
Hemoglobin, g/L 12.5 (1.9) 13.9 16.7 15 15.7 14 18.3
Hematocrit, % 37.9 (5.8) 38.4 58.6 43.1 47.4 39.5 54.4
Mean cell volume, fL 55.6 (5.5) 54.3 69.3 57 56.8 54.7 57.1
Aspartate aminotransferase, U/L 52 (35) 161 119 162 145 492 500
Alanine aminotransferase, U/L 98 (71) 157 412 377 284 501 471
Creatine phosphokinase, U/L 296 (311) 262 200 915 746 >2,000 >2,000
Lactate dehydrogenase, U/L 92 (87) 273 203 574 174 684 906
Total bilirubin, mg/dL 0.3 (0.2) 2.7 0.6 2.9 1.2 5.4 12.3

*Numbers are obtained from (12).
†After illness onset.
‡Day 1 was 20 days after cheetah 1 died.
§Blood was collected from the carcass.
¶Possible lower platelet counts due to blood collection using heparin.

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References
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