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May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


p-tert-Butyltoluene

CAS number: 98–51–1

NIOSH REL: 10 ppm (60 mg/m3) TWA, 20 ppm (120 mg/m3) STEL

Current OSHA PEL: 10 ppm (60 mg/m3) TWA

1989 OSHA PEL: 10 ppm (60 mg/m3) TWA, 20 ppm (120 mg/m3) STEL

1993-1994 ACGIH TLV: 1 ppm (6.1 mg/m3) TWA

Description of Substance: Colorless liquid with a distinct aromatic odor, somewhat like gasoline.

LEL: . . Unknown

Original (SCP) IDLH: 1,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the female rat 1-hour LC50 of 934 ppm reported by Hine et al. [1954].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

 


Species

Reference
LC50

(ppm)

LCLo

(ppm)


Time
Adjusted 0.5-hr

LC (CF)

Derived value
Rat

Rat

Rat

Rat

Mouse

Hine et al. 1954

Hine et al. 1954

Hine et al. 1954

Hine et al. 1954

Hine et al. 1954

934

734

248

165

248

-----

-----

-----

-----

-----

1 hr

2 hr

4 hr

8 hr

4 hr

1,168 ppm (1.25)

1,174 ppm (1.6)

496 ppm (2.0)

413 ppm (2.5)

496 ppm (2.0)

117 ppm

117 ppm

50 ppm

41 ppm

50 ppm


Other animal data: RD50 (mouse), 360 ppm [Nielsen and Alarie 1982].

Human data: Giddiness and altered respiration have been reported in volunteers exposed to 160 ppm for 15 minutes [Hine et al. 1954].

 

Revised IDLH: 100 ppm

Basis for revised IDLH: The revised IDLH for p-tert-butyltoluene is 100 ppm based on acute inhalation toxicity data in humans [Hine et al. 1954].


REFERENCES:

1. Hine CH, Ungar H, Anderson HH, Kodama JK, Critchlow JK, Jacobsen NW [1954]. Toxicological studies on p-tertiary-butyltoluene. AMA Arch Ind Hyg Occup Med 9:227-244.

2. Nielsen GD, Alarie Y [1982]. Sensory irritation, pulmonary irritation, and respiratory stimulation by airborne benzene and alkylbenzenes: prediction of safe industrial exposure levels and correlation of their thermodynamic properties. Toxicol Appl Pharmacol 65:459-477.

 
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