Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)
CAS number: 96–18–4
NIOSH REL: 10 ppm (60 mg/m3) TWA [skin]; NIOSH considers 1,2,3-trichloropropane to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
Current OSHA PEL: 50 ppm (300 mg/m3) TWA
1989 OSHA PEL: 10 ppm (60 mg/m3) TWA
1993-1994 ACGIH TLV: 10 ppm (60 mg/m3) TWA [skin]
Description of substance: Colorless liquid with a chloroform-like odor.
LEL(@248°F) : 3.2% (10% LEL(@248°F), 3,200 ppm)
Original (SCP) IDLH: 1,000 ppm
Basis for original (SCP) IDLH: UCC  reported that 5 of 6 rats died following a 1-hour exposure to 5,600 ppm. Because several mice died following only a 20-minute exposure to 5,000 ppm [McOmie and Barnes 1949 as cited by ACGIH 1971], 5,000 ppm has not been chosen as the IDLH. The chosen IDLH is based on the rat 4-hour LCLO of 1,000 ppm [Smyth et al. 1962 cited by NIOSH 1976].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
|Mouse||Izmerov et al. 1982||555||-----||2 hr||888 ppm (1.6)||89 ppm|
|Mouse||McOmie & Barnes 1949||-----||5,000||20 min||4,350 ppm (0.87)||435 ppm|
|Rat||McOmie & Barnes 1949||LC100: 700||-----||4 hr||1,400 ppm (2.0)||140 ppm|
|Mouse||McOmie & Barnes 1949||LC100: 700||-----||4 hr||1,400 ppm (2.0)||140 ppm|
|Mouse||McOmie &Barnes 1949||LC100: 340||-----||4 hr||680 ppm (2.0)||68 ppm|
|Rat||Smyth et al. 1962||LC83: 1,000||-----||4 hr||2,000 ppm (2.0)||200 ppm|
|Rat||UCC 1973||LC83: 5,600||-----||1 hr||7,000 ppm (1.25)||700 ppm|
Human data: It has been reported that objectionable ocular
and mucosal irritation were experienced after 15 minutes of exposure
to 100 ppm [Silverman et al. 1946].
|Revised IDLH: 100 ppm
Basis for revised IDLH: The revised IDLH for 1,2,3-trichloropropane is 100 ppm based on acute inhalation toxicity data in humans [Silverman et al. 1946]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 100 ppm. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for 1,2,3-trichloropropane at concentrations above 10 ppm.]
1. ACGIH . 1,2,3-Trichloropropane. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 266-267.
2. Izmerov NF, Sanotsky IV, Sidorov KK . Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 114.
3. McOmie WA, Barnes TR . Acute and subchronic toxicity of 1,2,3-trichloropropane in mice and rabbits. Fed Proc 8:319.
4. NIOSH . TZ92750. Propane, 1,2,3-trichloro-. In: Registry of toxic effects of chemical substances, 1976 ed. Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-191, p. 969.
5. Silverman L, Schulte HF, First MW . Further studies on sensory response to certain industrial solvent vapors. J Ind Hyg Toxicol 28:262-266.
6. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA . Range finding toxicity data: list VI. Am Ind Hyg Assoc J 23:95-107.
7. UCC . Toxicology studies: 1,2,3-trichloropropane. New York, NY: Union Carbide Corporation.
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