Skip directly to local search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options
CDC Home
May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


ANTU

CAS number: 86-88-4

NIOSH REL: 0.3 mg/m3 TWA

Current OSHA PEL: 0.3 mg/m3 TWA

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 0.3 mg/m3 TWA

Description of substance: White crystalline or gray, odorless powder.

LEL: Noncombustible Solid

Original (SCP) IDLH: 100 mg/m3

Basis for original (SCP) IDLH: No useful acute inhalation toxicity data are available on which to base the IDLH for ANTU. The chosen IDLH, therefore, has been estimated from the fatal human oral dose of 1 gram given by Stolman [1969]. According to ACGIH [1971], McClosky and Smith [1945] reported that the acute oral toxicity varies greatly among different species, with rats and dogs being the most susceptible (LD50 of 30 to 50 mg/kg) and rabbits the least susceptible (LD50 of 1,000 mg/kg).

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal dose data:

SpeciesReferenceRouteLD50(mg/kg)LDLo(mg/kg)Adjusted LDDerived Value
DogAAPCO 1966oral0.38-----2.7 mg/m30.3 mg/m3
RatLehman 1952oral6----- 42 mg/m34.2 mg/m3
MonkeyPerkow 1971/76oral4,250-----29,750 mg/m32,975 mg/m3
MouseYakkyoku 1977oral5----- 35 mg/m33.5 mg/m3

Other animal data: It has been reported that the mean oral lethal dose is 4,000 mg/kg in monkeys and is presumably much the same in man [Gosselin et al. 1984].

Human data: The fatal oral dose has been reported to be 1,000 mg [Stolman 1969]. [Note: An oral dose of 1,000 mg is equivalent to a worker being exposed to 650 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]

Revised IDLH: 100 mg/m3 [Unchanged]

Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for ANTU. However, based on acute oral toxicity data in humans [Stolman 1969] and animals [Gosselin et al. 1984; Perkow 1971/76], the original IDLH for ANTU (100 mg/m3) is not being revised at this time.

REFERENCES:

  1. AAPCO [1966]. Pesticide chemicals official compendium. Topeka, KS: Association of American Pesticide Control Officials, Inc., p. 57.
  2. ACGIH [1971]. ANTU (alpha-naphthyl-thiourea). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 15-16.
  3. Gosselin RE, Smith RP, Hodge HC [1984]. Clinical toxicology of commercial products. 5th ed. Section III. Baltimore, MD: Williams and Wilkins Company, pp. 40-42.
  4. Lehman AJ [1952]. Chemicals in foods: a report to the Association of Food and Drug Officials on current developments. Part II. Pesticides. Section III. Subacute and chronic toxicity. Q Bulletin Assoc Food Drug Off U.S. 16:47-53.
  5. McClosky WT, Smith MI [1945]. Studies on the pharmacologic action and the pathology of alpha-naphthylthiourea (ANTU). I. Pharmacology. Public Health Rep 60(38):1101-1113.
  6. Perkow W [1971/76]. Wirksubstanzen der pflanzenschutz und schadlingsbekampfungsmittel. Berlin, Germany: Verlag Paul Parey (in German).
  7. Stolman A, ed. [1969]. Progress in chemical toxicology. Vol. 4. New York, NY: Academic Press, p. 235.
  8. Yakkyoku (Pharmacy) [1977]; 28:329-335 (in Japanese).
 
Contact Us:
USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO