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May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


Chlorinated camphene

CAS number: 8001–35–2

NIOSH REL: None established; NIOSH considers chlorinated camphene to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].

Current OSHA PEL: 0.5 mg/m3 TWA [skin]

1989 OSHA PEL: 0.5 mg/m3 TWA, 1 mg/m3 STEL [skin]

1993-1994 ACGIH TLV: 0.5 mg/m3 TWA, 1 mg/m3 STEL [skin]

Description of Substance: Amber, waxy solid with a mild, piney, chlorine- and camphor-like odor.

LEL: . . Noncombustible Solid

Original (SCP) IDLH: 200 mg/m3

Basis for original (SCP) IDLH: The chosen IDLH has been estimated from the statement by Patty [1963] from the Council on Pharmacy and Chemistry [1952], Deichmann and Gerarde [1969], Stolman [1969], Thienes and Haley [1972], and Sax [1968] that the human oral lethal dose is about 2 to 7 grams.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

 


Species

Reference

LC50

LCLo

Time
Adjusted 0.5-hr

LC (CF)

Derived

value

MouseWermer 1952----- 2,000 mg/m32 hr3,200 mg/m3 (1.6)320 mg/m3


Lethal dose data:

 


Species

Reference

Route
LD50

(mg/kg)

LDLo

(mg/kg)


Adjusted LD
Derived

value

Rabbit

Mouse

G. pig

Rat

Hartley and Kidd 1983-86

Kenaga and Morgan 1978

Perkow 1971/76

von Schwabe and Wendling 1967

oral

oral

oral

oral

75

112

250

50

-----

-----

-----

-----

525 mg/m3

784 mg/m3

1,750 mg/m3

350 mg/m3

53 mg/m3

78 mg/m3

175 mg/m3

35 mg/m3


Human data: No toxic responses were noted in 25 volunteers exposed to 500 mg/m3 for 30 minutes/day for 10 consecutive days [Shelansky 1947]. The oral lethal dose has been reported to be about 2 to 7 grams [Thienes and Haley 1972]. [Note: An oral dose of 2 to 7 grams is equivalent to a worker being exposed to about 1,300 to 4,700 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]

 

Revised IDLH: 200 mg/m3 [Unchanged]

Basis for revised IDLH: Based on acute inhalation toxicity data in humans [Shelansky 1947], a value of about 500 mg/m3 would have been appropriate. However, the original IDLH of 200 mg/m3 is not being revised at this time. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for chlorinated camphene at any detectable concentration.]


REFERENCES:

1. Deichmann WB, Gerarde HW [1969]. Toxaphene (synthetic 3956; chlorinated camphene). In: Toxicology of drugs and chemicals. New York, NY: Academic Press, Inc., p. 598.

2. Hartley D, Kidd H [1983-86]. The agrochemicals handbook. Nottingham, England: Royal Society of Chemistry, p. A054.

3. Kenaga EE, Morgan RW [1978]. Commercial and experimental organic insecticides (1978 revision). Entomological Society of America, Special Publication 78-1:13.

4. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1360.

5. Perkow W [1971/76]. Wirksubstanzen der pflanzenschutz und schadlingsbekampfungsmittel. Berlin, Germany: Verlag Paul Parey (in German).

6. Sax NI [1968]. Dangerous properties of industrial materials. 3rd ed. New York, NY: Van Nostrand Reinhold Company, p. 1172.

7. Shelansky H [1947]. Unpublished report to Hercules, Inc. In: ACGIH [1971]. Chlorinated camphene (60%). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 115.

8. Stolman A, ed. [1969]. Progress in chemical toxicology. Vol. 4. New York, NY: Academic Press, p. 195.

9. Stormont RT, Conley BE [1952]. Report to the Council on Pharmacy and Chemistry: pharmacologic properties of toxaphene, a chlorinated hydrocarbon insecticide. JAMA 149(12):1135-1137.

10. Thienes CH, Haley TJ [1972]. Clinical toxicology. 5th ed. Philadelphia, PA: Lea & Febiger, pp. 26-27.

11. von Schwabe V, Wendling I [1967]. Beschleunigung des arzneimittel-abbaus durch kleine dosen von DDT und anderen chlorkoblenwasserstoff-insekticiden. Arzneimittel-Forschung (Drug Research) 17:614-618 (in German).

12. Wermer PL [1952]. Pharmacological properties of toxaphene, a chlorinated hydrocarbon insecticide. JAMA 149:1135-1137.

 
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