Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)
CAS number: 79-27-6
NIOSH REL: The 1989 OSHA PEL may not be protective to workers.
Current OSHA PEL: 1 ppm (14 mg/m3) TWA
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 1 ppm (14 mg/m3) TWA
Description of substance: Pale-yellow liquid with a pungent odor similar to camphor or iodoform.
LEL: Noncombustible Liquid
Original (SCP) IDLH: 10 ppm
Basis for original (SCP) IDLH: Van Haaften  reported that a chemist who had been exposed to 1 to 2 ppm for 7.5 hours, with only a single 10-minute exposure at 16 ppm, almost died from liver damage. Because the TLV is 1 ppm [ACGIH 1976], it is assumed that exposure to 1 to 2 ppm would be a safe concentration for the 7.5 hours the worker was exposed. Therefore, the injury must have been produced by the 10-minute exposure to 16 ppm, and the IDLH would be expected to fall between 2 ppm and 15 ppm. For this draft technical standard, an IDLH of 10 ppm is assumed. This is an extremely toxic substance.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
|Species||Reference||LC50(ppm)||LCLo(ppm)||Time||Adjusted||0.5-hr LC (CF)||Derived Value|
|Rat||Izmerov et al. 1982||38||-----||4 hr||76 ppm||(2.0)||7.6 ppm|
Lethal dose data:
|Species||Reference||Route||LD50(mg/kg)||LDLo(mg/kg)||Adjusted LD||Derived Value|
|G. pig||Gray 1950||oral||400||-----||195 ppm||20 ppm|
|Rabbit||Gray 1950||oral||400||-----||195 ppm||20 ppm|
|Mouse||Izmerov et al.1982||oral||269||-----||131 ppm||13 ppm|
|Rat||Paustovskaya et al. 1967||oral||1,200||-----||585 ppm||59 ppm|
Human data: Severe acute intoxication was reported in a chemist after exposure to 16 ppm for about 10 minutes and to 1 to 2 ppm for most of the day [Van Haaften 1969].
Revised IDLH: 8 ppm
Basis for revised IDLH: The revised IDLH for acetylene tetrabromide is 8 ppm based on acute inhalation toxicity data in animals [Izmerov et al. 1982].
- ACGIH . TLVs, Threshold limit values for chemical substances and physical agents in the workroom environment with intended changes for 1976. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 9.
- Gray MG . Effect of exposure to the vapors of tetrabromoethane (acetylene tetrabromide). AMA Arch Ind Hyg Occup Med 2:407-419.
- Izmerov NF, Sanotsky IV, Sidorov KK . Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 107.
- Paustovskaya VV, et al. . Effect of tetrabromomethane on the parenchymatous organs in experimental conditions. Med Pr 3:80-83 (in Polish).
- Van Haaften AB . Acute tetrabromoethane (acetylene tetrabromide) intoxication in man. Am Ind Hyg Assoc J 30:251-256.
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