Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)
CAS number: 78–92–2
NIOSH REL: 100 ppm (305 mg/m3) TWA, 150 ppm (455 mg/m3) STEL
Current OSHA PEL: 150 ppm (450 mg/m3) TWA
1989 OSHA PEL: 100 ppm (305 mg/m3) TWA
1993-1994 ACGIH TLV: 100 ppm (303 mg/m3) TWA
Description of Substance: Colorless liquid with a strong, pleasant odor.
LEL(@212 F): 1.7% (10% LEL(@212 F), 1,700 ppm)
Original (SCP) IDLH: 10,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the statements by Patty  that 10,670 ppm for 225 minutes and 16,000 ppm for 160 minutes were fatal for mice [Weese 1928]. According to Patty , at 20,000 ppm it took 12 to 20 minutes to produce prostration in mice and 40 minutes to produce narcosis; no deaths occurred [Starrek 1938]. The chosen IDLH is probably conservative.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
|32,000 ppm (2.0) |
20,913 ppm (1.96)
28,000 ppm (1.75)
Other animal data: The limited acute toxicity data indicate that sec-butyl alcohol is less toxic than n-butyl alcohol [ACGIH 1991].
Human data: None relevant for use in determining the revised IDLH.
|Revised IDLH: 2,000 ppm
Basis for revised IDLH: The revised IDLH for sec-butyl alcohol is 2,000 ppm based on acute inhalation toxicity data in animals [Weese 1928]. This value also approximates 10% of the lower explosive limit (LEL) of 1.7% (which was determined at 212 F) and the revised IDLH for n-butyl alcohol. This may be a conservative value due to the lack of relevant acute toxicity data for workers.
1. ACGIH . sec-Butyl alcohol. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 172-173.
2. Patty FA, ed. . Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1447.
3. Shell . Material safety data sheet S280-4: secondary butyl alcohol. Houston, TX: Shell Chemical Company, pp. 1-4.
4. Starrek E . The effect of some alcohols, glycols, and esters. Doctoral dissertation (translated). Wurzburg, Germany: Julius Maximillian University.
5. Weese H . Comparative studies of the effect and toxicity
of the vapors of lower aliphatic alcohols. Arch Exp Pathol Pharmakol
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