Skip directly to local search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options
CDC Home
May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


Phosdrin

CAS number: 7786–34–7

NIOSH REL: 0.01 ppm (0.1 mg/m3) TWA, 0.03 ppm (0.3 mg/m3) STEL [skin]

Current OSHA PEL: 0.1 mg/m3 TWA [skin]

1989 OSHA PEL: 0.01 ppm (0.1 mg/m3) TWA, 0.03 ppm (0.3 mg/m3) STEL [skin]

1993-1994 ACGIH TLV: 0.01 ppm (0.92 mg/m3) TWA,

0.03 ppm (0.27 mg/m3) STEL [skin]

Description of substance: Pale-yellow to orange liquid with a weak odor.

LEL: . . Unknown

Original (SCP) IDLH: 4 ppm

Basis for original (SCP) IDLH: No useful data on acute inhalation toxicity are available on which to base the IDLH for Phosdrin. The chosen IDLH has been estimated from the male rat oral LD50 of 6 to 7 mg/kg [Shell 1956 cited by ACGIH 1971]. [Note: A concentration of 4 ppm phosdrin is equivalent to about 40 mg/m3.]

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal concentration data:

 

SpeciesReferenceLC50 (ppm)LCLo (ppm)TimeAdjusted 0.5-hr LC (CF)Derived value
RatKodama et al. 1954 14-----1 hr18 ppm (1.25)1.8 ppm

Lethal dose data:

 

SpeciesReferenceRouteLD50 (mg/kg)LDLo (mg/kg)Adjusted LDDerived value
Rat

Mouse

Rat

Kenaga 1979

Kodama et al. 1954

Shell 1956

oral

oral

oral

3

4

6-7

-----

-----

-----

2.3 ppm

3.0 ppm

4.5-5.3 ppm

0.2 ppm

0.3 ppm

0.5 ppm

Human data: A dose of 2.5 mg/day for 27 days caused a 25% decrease in red blood cell cholinesterase [Rider et al. 1975]. [Note: An oral dose of 2.5 mg/day for 27 days is equivalent to a worker being exposed to about 5 ppm for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]

 

Revised IDLH: 4 ppm [Unchanged]

Basis for revised IDLH: Based on acute toxicity data in humans [Rider et al. 1975], the original IDLH for phosdrin (4 ppm) is not being revised at this time.

REFERENCES:

1. ACGIH [1971]. Phosdrin (mevinphos). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 208.

2. Kenaga EE [1979]. Acute and chronic toxicity of 75 pesticides to various animal species. Down to Earth 35:25-31.

3. Kodama J, Morse MS, Anderson HH, Dunlap MK, Hines CH [1954]. Comparative toxicity of two vinyl-substituted phosphates. AMA Arch Ind Hyg Occup Med 9:45-61.

4. Rider JA, Puletti EJ, Swader JI [1975]. The minimal oral toxicity level for mevinphos in man. Toxicol Appl Pharmacol 32(10):97-100.

5. Shell [1956]. Personal communication to ACGIH from the Shell Chemical Corporation, August 31, 1956. [From ACGIH [1991]. Phosdrin. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1044-1046.]

 
Contact Us:
USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Road Atlanta, GA 30329-4027, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO