Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)
CAS number: 7580–67–8
NIOSH REL: 0.025 mg/m3 TWA
Current OSHA PEL: 0.025 mg/m3 TWA
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 0.025 mg/m3 TWA
Description of substance: Odorless, off-white to gray, translucent, crystalline mass or white powder.
LEL :. . Noncombustible Solid
Original (SCP) IDLH*: 55 mg/m3 [*Note: "Effective" IDLH = 50 mg/m3 -- see discussion below.]
Basis for original (SCP) IDLH: The chosen IDLH of 55 mg/m3 is based on the statement by Patty  that "animals exposed to 5 to 55 mg/m3 for periods up to 4 hours experienced intense irritation, coughing and sneezing, inflammation of the conjunctiva, partial sloughing of mucosal epithelium of trachea, and some pulmonary emphysema. No mortality occurred (however) as a result of any level of exposure [Spiegl et al. 1956]." Spiegl et al. , however, found that 2 of 10 animals died from a 4-hour exposure at 22 mg/m3; Spiegl et al.  stated, though, that the mortality among rats, rabbits, guinea pigs, and mice exposed to levels of from 5 to 55 mg/m3 for 1 day was low and probably unrelated to the exposure. A statement by ACGIH  (i.e., that industrial experience has shown that a reduction in atmospheric concentration to 25 µg/m3 is required to attain just a sneezing level), indicates that 22 mg/m3 is too low to be the IDLH. Respirators have been selected on the basis of the assigned protection factor afforded by each device up to 2,000 ´ OSHA PEL of 0.025 mg/m3 (i.e., 50 mg/m3); only the "most protective" respirators are permitted for use in concentrations exceeding 50 mg/m3.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
|Species||Reference||LC50||LCLo||Time||Adjusted 0.5-hr LC (CF)||Derived value|
|Rat||Spiegl et al. 1956||LC20: 22 mg/m3||-----||4 hr||44 mg/m3 (2.0)||4.4 mg/m3|
Human data: It has been recommended that 0.5 mg/m3
is the maximum tolerable concentration for brief period of exposure
|Revised IDLH: 0.5 mg/m3
Basis for revised IDLH: The revised IDLH for lithium hydride is 0.5 mg/m3 based on acute inhalation toxicity data in humans [AIHA 1964].
1. ACGIH . Lithium hydride. In: Documentation of the Threshold Limit Values for Substances in Workroom Air, 3rd edition. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 147.
2. AIHA . Lithium hydride. In: Hygienic guide series. Akron, OH: American Industrial Hygiene Association.
3. Patty FA, ed. . Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1070.
4. Spiegl CJ, Scott JK, Steinhardt H, Leach LJ, Hodge HC . Acute inhalation toxicity of lithium hydride. AMA Arch Ind Health 14:468-470.
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