Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)
CAS number: 75–69–4
NIOSH REL: 1,000 ppm (5,600 mg/m3) CEILING
Current OSHA PEL: 1,000 ppm (5,600 mg/m3) TWA
1989 OSHA PEL: 1,000 ppm (5,600 mg/m3) CEILING
1993-1994 ACGIH TLV: 1,000 ppm (5,620 mg/m3) CEILING
Description of Substance: Colorless to water-white, nearly odorless liquid or gas (above 75 F).
LEL: . . Noncombustible Liquid/Nonflammable Gas
Original (SCP) IDLH: 10,000 ppm
Basis for original (SCP) IDLH: Scheel (member of the Standards Completion Program Respirator Committee), in evaluating the work of Reinhardt et al. , indicated cardiac toxicity occurred at 12,000 ppm. The chosen IDLH is based on that data.
Existing short-term exposure guidelines: National Research Council [NRC 1984] Emergency Exposure Guidance Levels (EEGLs):
1-hour EEGL: 1,500 ppm
24-hour EEGL: 500 ppm
ACUTE TOXICITY DATA
Lethal concentration data:
Lester and Greenberg 1950
|52,400 ppm (2.0) |
96,000 ppm (0.96)
160,000 ppm (1.6)
Other animal data: Evidence of serious arrhythmia was noted in 1 of 12 conscious dogs exposed for 5 minutes to 5,000 ppm plus intravenous epinephrine [Reinhardt et al. 1971]. However, in another study, endogenous epinephrin was not sufficient to precipitate arrythmia in dogs exposed to 5,000 to 10,000 ppm [Reinhardt et al. 1971].
Human data: None relevant for use in determining the revised IDLH.
|Revised IDLH: 2,000 ppm
Basis for revised IDLH: The revised IDLH for fluorotrichloromethane is 2,000 ppm based on acute toxicity data in animals [Reinhardt et al. 1971] and to be consistent with a closely-related chlorofluorocarbon, 1,1,2-trichloro-1,2,2-trifluoroethane which has a revised IDLH of 2,000 ppm.
1. Barras CE . Unpublished data. Wilmington, DE: DuPont Company, Haskell Laboratory (October 1974). [From ACGIH . Documentation of the threshold limit values for substances in workroom air. 5th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 598.]
2. Lester D, Greenberg LA . Acute and chronic toxicity of some halogenated derivatives of methane and ethane. AMA Arch Ind Hyg Occup Med 2:335-344.
3. Mullin LS, Azar A, Reinhardt CF, Smith PE, Fabryka EF . Halogenated hydrocarbon-induced cardiac arrhythmias associated with release of endogenous epinephrine. Am Ind Hyg Assoc J 33(6):389-396.
4. NRC . Emergency and continuous exposure limits for selected airborne contaminants. Vol. 2. Washington, DC: National Academy Press, Committee on Toxicology, Board on Toxicology and Environmental Health Hazards, Commission on Life Sciences, National Research Council, pp. 26-33.
5. Reinhardt CF, Azar A, Maxfield ME, Smith PE, Mullin LS . Cardiac arrhythmias and aerosol "sniffing." Arch Environ Health 22:265-279.
6. Scholz J . New toxicological investigations on certain
types of freon used as propellants. Fortschr Biol Aerosol-forsch
Jahren 1957-1961. Ber Aerosol Kongr 4:420-429.
[From ACGIH . Trichlorofluoromethane. In: Documentation
of the threshold limit values and biological exposure indices.
6th ed. Cincinnati, OH: American Conference of Governmental Industrial
Hygienists, pp. 619-623.]
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