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May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


Dimethylformamide

CAS number: 68–12–2

NIOSH REL: 10 ppm (30 mg/m3) TWA [skin]

Current OSHA PEL: 10 ppm (30 mg/m3) TWA [skin]

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 10 ppm (30 mg/m3) TWA [skin]

Description of Substance: Colorless to pale-yellow liquid with a faint, amine-like odor.

LEL(@212 F): 2.2% (10% LEL(@212 F), 2,200 ppm)

Original (SCP) IDLH: 3,500 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statements by Clayton et al. [1963] that rats survived a 4-hour exposure to air saturated with dimethylformamide vapor [Smyth and Carpenter 1948] and inhalation of saturated vapors for 6 hours was lethal [Haskell Laboratory]. A.D. Little reports that the saturated concentration at 20 C is 3,550 ppm. Because exposures to rats for 4 hours were at saturated concentrations, 3,500 ppm is chosen as the IDLH.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

 


Species

Reference
LC50

(ppm)

LCLo

(ppm)


Time
Adjusted 0.5-hr

LC (CF)

Derived

value

Rat

Mouse

Haskell

Stasenkova 1961

-----

3,092

5,000

-----

6 hr

2 hr

11,500 ppm (2.3)

4,947 ppm (1.6)

1,150 ppm

496 ppm


Lethal dose data:

 


Species

Reference

Route
LD50

(mg/kg)

LDLo

(mg/kg)


Adjusted LD

Derived value
Rat

Mouse

Rat

Druckrey et al. 1967

Lobanova 1958

Massmann 1956

oral

oral

oral

2,800

3,700

3,500

-----

-----

-----

6,447 ppm

8,520 ppm

8,059 ppm

645 ppm

852 ppm

806 ppm


Human data: None relevant for use in determining the revised IDLH.

 

Revised IDLH: 500 ppm

Basis for revised IDLH: The revised IDLH for dimethylformamide is 500 ppm based on acute inhalation toxicity data in animals [Stasenkov 1961].


REFERENCES:

1. A.D. Little [?]. A.D. Little, Inc. Information supplied to NIOSH during Standards Completion Project.

2. Clayton JW Jr, Barnes JR, Hood DB, Schepers GWH [1963]. The inhalation toxicity of dimethylformamide (DMF). Am Ind Hyg Assoc J 24:144-154.

3. Druckrey H, Preussmann R, Ivankovic S, Schmahl D [1967]. Organotrope carcinogene wirkungen bei 65 vershiedenen N-nitroso-verbindungen and BD-ratten. Zeitschrift für Krebsforschung 69:103-201 (in German).

4. Haskell Laboratory [?]. Unpublished report. [From Clayton JW Jr, Barnes JR, Hood DB, Schepers GWH [1963]. The inhalation toxicity of dimethylformamide (DMF). Am Ind Hyg Assoc J 24:144-154.]

5. Lobanova KP [1958]. Concerning the toxicity of dimethylformamide. Gig Tr Prof Zabol 23(5):31-37 (in Russian).

6. Massmann W [1956]. Toxicological investigations on dimethylformamide. Br J Ind Med 13:51-54.

7. Smyth HF Jr, Carpenter CP [1948]. Further experience with the range-finding test in the industrial toxicology laboratory. J Ind Hyg Toxicol 30(1):63-68.

8. Stasenkova KP [1961]. Toxicity of dimethylformamide. Toksikol Nov Prom Khim Vesh 1:54-69 (in Russian).

 
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