sec-Amyl acetate

CAS number: 626-38-0

NIOSH REL: 125 ppm (650 mg/m3) TWA

Current OSHA PEL: 125 ppm (650 mg/m3) TWA

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 125 ppm (665 mg/m3) TWA

Description of substance: Colorless liquid with a mild odor.

LEL: 1% (10% LEL, 1,000 ppm)

Original (SCP) IDLH: 9,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1971] that 9,200 ppm was lethal to guinea pigs in 7 hours [Patty et al. 1936]. This is the only data on acute inhalation toxicity available on which to base the IDLH.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:
  Adjusted  
  LC50 LCLo   0.5-hr Derived
Species Reference (ppm) (ppm) Time LC (CF) Value
G. pig Patty et al. 1936 ----- 9,200 7 hr 22,080 ppm (2.4) 2,208 ppm
G. pig von Oettingen 1960 ----- 10,000 5 hr 21,500 ppm (2.15) 2,150 ppm

Human data: It has been stated that exposure to 1,000 ppm for an hour may be expected to produce serious toxic effects [von Oettingen 1960].

Revised IDLH: 1,000 ppm

Basis for revised IDLH: The revised IDLH for sec-amyl acetate is 1,000 ppm based on acute inhalation toxicity data in humans [von Oettingen 1960] and the similarity of the toxic effects of sec-amyl acetate to those of n-amyl acetate (which also has a revised IDLH of 1,000 ppm).

References:

  1. ACGIH [1971]. sec-Amyl acetate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 13.
  2. Patty FA, Yant WP, Schrenk HH [1936]. Acute response of guinea pigs to vapors of some new commercial organic compounds. XI. Secondary amyl acetate. Public Health Rep 51(25):811-819.
  3. von Oettingen WF [1960]. The aliphatic acids and their esters: toxicity and potential dangers. AMA Arch Ind Health 21:40/28-77/65.

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