May 1994

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)

1-Chloro-1-nitropropane

CAS number: 600–25–9

NIOSH REL: 2 ppm (10 mg/m³) TWA

Current OSHA PEL: 20 ppm (100 mg/m³) TWA

1989 OSHA PEL: 2 ppm (10 mg/m³) TWA

1993-1994 ACGIH TLV: 2 ppm (10 mg/m³) TWA

Description of Substance: Colorless liquid with an unpleasant odor.

LEL: . . Unknown

Original (SCP) IDLH: 2,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement in Patty [1963] that 1 of 2 guinea pigs died following a 1-hour exposure to 2,178 ppm; no rabbits died from this exposure, and no rabbits or guinea pigs died from a 1-hour exposure to 1,069 ppm [Machle et al. 1945].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Species

Reference

LC₅₀

(ppm)

LC_Lo

(ppm)

Time

Adjusted 0.5-hr

LC (CF)

Derived

value

G. pig

Rabbit

G. pig

Mouse

Machle et al. 1945

Neklesova and Kudrina 1969

2,178

-----

LC₁₀₀: 2,574

-----

12,840

-----

389

-----

3,502

-----

1 hr

6 hr

2 hr

3 hr

2,723 ppm (1.25)

895 ppm (2.3)

5,920 ppm (2.3)

5,603 ppm (1.6)

23,112 ppm (1.8)

272 ppm

90 ppm

592 ppm

560 ppm

2,311 ppm

Lethal dose data:

Species

Reference

Route

LD₅₀

(mg/kg)

LD_Lo

(mg/kg)

Adjusted LD

Derived value

Rabbit

Rat

Mouse

Machle et al. 1945

Marhold 1986

Neklesova and Kudrina 1969

oral

-----

510

-----

68 ppm

695 ppm

6.8 ppm

70 ppm

Human data None relevant for use in determining the revised IDLH.

Revised IDLH: 100 ppm

Basis for revised IDLH: The revised IDLH for 1-chloro-1-nitropropane is 100 ppm based on acute inhalation toxicity data in animals [Machle et al. 1945].

REFERENCES:

1. Machle W, Scott EW, Treon JF, Heyroth FF, Kitzmiller KV [1945]. The physiological response of animals to certain chlorinated mononitroparaffins. J Ind Hyg Toxicol 27(4):95-102.

2. Marhold J [1986]. Prehled Prumyslove Toxikologie, Organicke Latky. Prague, Czechoslovakia: Avicenum, p. 596 (in Czechoslovakian).

3. Neklesova ID, Kudrina MA [1969]. Comparative toxicological characteristics of certain chloronitroparaffins. Gig Sanit 34(10-12):429-432 (translated).

4. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 2082.