Skip directly to local search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options
CDC Home
Share
Compartir
May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


1-Chloro-1-nitropropane

CAS number: 600–25–9

NIOSH REL: 2 ppm (10 mg/m3) TWA

Current OSHA PEL: 20 ppm (100 mg/m3) TWA

1989 OSHA PEL: 2 ppm (10 mg/m3) TWA

1993-1994 ACGIH TLV: 2 ppm (10 mg/m3) TWA

Description of Substance: Colorless liquid with an unpleasant odor.

LEL: . . Unknown

Original (SCP) IDLH: 2,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement in Patty [1963] that 1 of 2 guinea pigs died following a 1-hour exposure to 2,178 ppm; no rabbits died from this exposure, and no rabbits or guinea pigs died from a 1-hour exposure to 1,069 ppm [Machle et al. 1945].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

 


Species

Reference
LC50

(ppm)

LCLo

(ppm)


Time
Adjusted 0.5-hr

LC (CF)

Derived

value

G. pig

Rabbit

Rabbit

G. pig

Mouse

Machle et al. 1945

Machle et al. 1945

Machle et al. 1945

Machle et al. 1945

Neklesova and Kudrina 1969

2,178

-----

LC100: 2,574

-----

12,840

-----

389

-----

3,502

-----

1 hr

6 hr

6 hr

2 hr

3 hr

2,723 ppm (1.25)

895 ppm (2.3)

5,920 ppm (2.3)

5,603 ppm (1.6)

23,112 ppm (1.8)

272 ppm

90 ppm

592 ppm

560 ppm

2,311 ppm


Lethal dose data:

 


Species

Reference

Route
LD50

(mg/kg)

LDLo

(mg/kg)


Adjusted LD

Derived value
Rabbit

Rat

Mouse

Machle et al. 1945

Marhold 1986

Neklesova and Kudrina 1969

oral

oral

oral

-----

-----

510

50

50

-----

68 ppm

68 ppm

695 ppm

6.8 ppm

6.8 ppm

70 ppm


Human data None relevant for use in determining the revised IDLH.

 

Revised IDLH: 100 ppm

Basis for revised IDLH: The revised IDLH for 1-chloro-1-nitropropane is 100 ppm based on acute inhalation toxicity data in animals [Machle et al. 1945].


REFERENCES:

1. Machle W, Scott EW, Treon JF, Heyroth FF, Kitzmiller KV [1945]. The physiological response of animals to certain chlorinated mononitroparaffins. J Ind Hyg Toxicol 27(4):95-102.

2. Marhold J [1986]. Prehled Prumyslove Toxikologie, Organicke Latky. Prague, Czechoslovakia: Avicenum, p. 596 (in Czechoslovakian).

3. Neklesova ID, Kudrina MA [1969]. Comparative toxicological characteristics of certain chloronitroparaffins. Gig Sanit 34(10-12):429-432 (translated).

4. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 2082.

 
Contact Us:
USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO