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May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


Paraquat

CAS number: 1910–42–5

NIOSH REL: 0.1 mg/m3 (respirable dust) TWA [skin]

Current OSHA PEL: 0.5 mg/m3 (respirable dust) TWA [skin]

1989 OSHA PEL: 0.1 mg/m3 (respirable dust) TWA [skin]

1993-1994 ACGIH TLV: 0.1 mg/m3 (respirable dust) TWA,

0.5 mg/m3 (total dust) TWA

Description of substance: Yellow solid with a faint, ammonia-like odor.

LEL: . Noncombustible Solid

Original (SCP) IDLH: 1.5 mg/m3

Basis for original (SCP) IDLH: The chosen IDLH is based on the statements by Gage [1968] that "after single exposures the LC50 appears to be a function of the duration and of the concentration; in the rat the lethal concentration-time product is about 6 micrograms/liter-hour. Guinea pigs and male mice are about as sensitive as rats. Female mice are less sensitive. The dog can tolerate a concentration-time product of 25 micrograms/liter-hour without ill effects."

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal concentration data:

 

SpeciesReferenceLC50 LCLoTimeAdjusted 0.5-hr

LC (CF)

Derived value
Respirable dust G. pigGage 1968 3 mg/m3-----30 min3.0 mg/m3 (1.0)0.30 mg/m3
Respirable dust MouseGage 1968 3 mg/m3-----30 min3.0 mg/m3 (1.0)0.30 mg/m3
Respirable dust RatGage 1968 ----- 1 mg/m36 hr2.3 mg/m3 (2.3)0.23 mg/m3
Nonrespirable dust RatPalazzolo 1965 ----- 6,400 mg/m34 hr12,800 mg/m3 (2.0)1,280 mg/m3

Lethal dose data:

 

SpeciesReferenceRouteLD50

(mg/kg)

LDLo

(mg/kg)

Adjusted LDDerived value
Rat

Mouse

Dog

G. pig

Bailey & White 1965

Barabas et al. 1981

Iyakuhin 1979

Murray &Gibson 1972

oral

oral

oral

oral

57

120

25

22

-----

-----

-----

-----

399 mg/m3

840 mg/m3

175 mg/m3

154 mg/m3

40 mg/m3

84 mg/m3

18 mg/m3

15 mg/m3

Human data: It has been stated that the high acute inhalation toxicity of paraquat is dependent wholly on the size of the particulate, with respirable sizes (i.e., <5 micrometer mass median diameter) found to be 5 to 6 times more toxic than nonrespirable dusts [McElligo 1965]. It has been reported that under paraquat spraying conditions particle sizes appear to be nonrespirable [Swan 1969].

 

Revised IDLH: 1 mg/m3

Basis for revised IDLH: The revised IDLH for paraquat is 1 mg/m3 based on the acute inhalation toxicity data for respirable particulate in animals [Gage 1968]. This is a conservative value if the occupational exposure is totally to nonrespirable size particles of paraquat since respirable aerosols are much more toxic [McElligo 1965; Swan 1969].

REFERENCES:

1. Bailey GW, White JL [1965]. Herbicides: a compilation of their physical, chemical, and biological properties. Residue Reviews 10:97-102.

2. Barabas K, Vigh L, Horvath I, Szabo L, Matkovics B [1981]. Effects of paraquat in vivo on fatty acids of mouse and guinea pig tissues. Gen Pharmacol 12:225-227.

3. Gage JC [1968]. Toxicity of paraquat and diquat aerosols generated by a size-selective cyclone: effect of particle size distribution. Br J Ind Med 25:304-314.

4. Iyakuhin Kenkyu (Study of Medical Supplies) [1979]; 10:520-522 (in Japanese).

5. McElligo TF [1965]. Industrial hygiene research lab report IHR/172. Alderly Park, Macclesfield, Cheshire, England: Imperial Chemicals Industries, Ltd. [From ACGIH [1991]. Paraquat. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1159-1161.]

6. Murray RE, Gibson JE [1972]. A comparative study of paraquat intoxication in rats, guinea pigs and monkeys. Exp Molec Pathol 17:317-325.

7. Palazzolo RF [1965]. Report to Imperial Chemical Industries, Ltd. Alderly Park, Macclesfield, Cheshire, England. [From ACGIH [1991]. Paraquat. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1159-1161.]

8. Swan AAB [1969]. Exposure of spray operators to paraquat. Br J Ind Med 26:322-329.

 
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