Skip directly to local search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options
CDC Home
May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


Acetic anhydride

CAS number: 108-24-7

NIOSH REL: 5 ppm (20 mg/m3) CEILING

Current OSHA PEL: 5 ppm (20 mg/m3) TWA

1989 OSHA PEL: 5 ppm (20 mg/m3) CEILING

1993-1994 ACGIH TLV: 5 ppm (21 mg/m3) TWA

Description of substance: Colorless liquid with a strong, pungent, vinegar-like odor.

LEL: 2.7% (10% LEL, 2,700 ppm)

Original (SCP) IDLH: 1,000 ppm

Basis for original (SCP) IDLH: According to AIHA [1971], all rats exposed for 4 hours to 2,000 ppm were dead within 14 days while all rats exposed for 4 hours to 1,000 ppm survived the 14-day observation period [Capellini and Sartorelli 1967]. Because 2,000 ppm is obviously too high to be selected as the IDLH, 1,000 ppm has been chosen.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:
  Adjusted  
  LC50 LCLo   0.5-hr Derived
Species Reference (ppm) (ppm) Time LC (CF) Value
Rat Deichmann and 1,000 ----- 4 hr 2,000 ppm (2.0) 200 ppm

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 200 ppm

Basis for revised IDLH: The revised IDLH for acetic anhydride is 200 ppm based on acute inhalation toxicity data in animals [Deichmann and Gerarde 1969]. This may be a conservative value due to the lack of relevant acute toxicity data for workers.

References:

  1. AIHA [1972]. Acetic anhydride. In: Hygienic guide series. Am Ind Hyg Assoc J 32(1):64-67.
  2. Capellini A, Sartorelli [1967]. Episodio di intossicazione collettiva da anidride acetica ed acido acetico. Med Lav 58:108-112 (in Italian).
  3. Deichmann WB, Gerarde HW [1969]. Trifluoroacetic acid (3FA). In: Toxicology of drugs and chemicals. New York, NY: Academic Press, Inc., p. 607.
 
Contact Us:
USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Road Atlanta, GA 30329-4027, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO