Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 107–87–9
NIOSH REL: 150 ppm (530 mg/m3) TWA
Current OSHA PEL: 200 ppm (700 mg/m3) TWA
1989 OSHA PEL: 200 ppm (700 mg/m3) TWA, 250 ppm (875 mg/m3) STEL
1993-1994 ACGIH TLV: 200 ppm (705 mg/m3) TWA, 250 ppm (881 mg/m3) STEL
Description of substance: Colorless to water-white liquid with a characteristic acetone-like odor.
LEL: . . 1.5% (10% LEL, 1,500 ppm)
Original (SCP) IDLH: 5,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by Patty  that the maximum concentration that caused no serious disturbances in guinea pigs in 1 hour was 5,000 ppm [Yant et al. 1936].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
|Species||Reference||LC50 (ppm)||LCLo (ppm)||Time||Adjusted 0.5-hr LC (CF)||Derived value|
|Rat||Smyth et al. 1962||LC17: 2,000||-----||4 hr||4,000 ppm (2.0)||400 ppm|
|Rat||Smyth et al. 1962||LC100: 4,000||-----||4 hr||8,000 ppm (2.0)||800 ppm|
|G. pig||Yant et al. 1936||-----||50,000||50 min||60,000 ppm (1.2)||6,000 ppm|
|G. pig||Yant et al. 1936||-----||13,000||5 hr||27,950 ppm (2.15)||2,795 ppm|
Lethal dose data:
|Species||Reference||Route||LD50 (mg/kg)||LDLo (mg/kg)||Adjusted LD||Derived value|
|Rat||Clayton and Clayton 1982||oral||1,600||-----||3,128 ppm||313 ppm|
|Mouse||Clayton and Clayton 1982||oral||1,600||-----||3,128 ppm||313 ppm|
Human data: Exposure to a concentration of 1,500 ppm was associated with complaints of ocular and upper respiratory irritation [Yant et al. 1936].
|Revised IDLH: 1,500 ppm |
Basis for revised IDLH: The revised IDLH for 2-pentanone is 1,500 ppm based on acute inhalation toxicity data in humans [Yant et al. 1936]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 1,500 ppm. Also, this value is 10% of the lower explosive limit of 1.5%.
1. Clayton GD, Clayton FE, eds. . Patty's industrial hygiene and toxicology. 3rd rev. ed. Vol. 2A. Toxicology. New York: John Wiley & Sons, Inc., p. 4735.
2. Patty FA, ed. . Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1734.
3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA . Range-finding toxicity data: list VI. AMA Arch Ind Hyg Occup Med 23:95-107.
4. Yant WP, Patty FA, Schrenk HH . Acute response of guinea pigs to vapors of some new commercial organic compounds. IX. Pentanone (methyl propyl ketone). Public Health Rep 51:392-399.
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