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May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


2-Pentanone

CAS number: 107–87–9

NIOSH REL: 150 ppm (530 mg/m3) TWA

Current OSHA PEL: 200 ppm (700 mg/m3) TWA

1989 OSHA PEL: 200 ppm (700 mg/m3) TWA, 250 ppm (875 mg/m3) STEL

1993-1994 ACGIH TLV: 200 ppm (705 mg/m3) TWA, 250 ppm (881 mg/m3) STEL

Description of substance: Colorless to water-white liquid with a characteristic acetone-like odor.

LEL: . . 1.5% (10% LEL, 1,500 ppm)

Original (SCP) IDLH: 5,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by Patty [1963] that the maximum concentration that caused no serious disturbances in guinea pigs in 1 hour was 5,000 ppm [Yant et al. 1936].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal concentration data:

 

SpeciesReferenceLC50 (ppm)LCLo (ppm)TimeAdjusted 0.5-hr LC (CF)Derived value
RatSmyth et al. 1962 LC17: 2,000-----4 hr4,000 ppm (2.0)400 ppm
RatSmyth et al. 1962 LC100: 4,000-----4 hr8,000 ppm (2.0)800 ppm
G. pigYant et al. 1936 -----50,00050 min60,000 ppm (1.2)6,000 ppm
G. pigYant et al. 1936 -----13,0005 hr27,950 ppm (2.15)2,795 ppm

Lethal dose data:

 

SpeciesReferenceRouteLD50 (mg/kg)LDLo (mg/kg)Adjusted LDDerived value
RatClayton and Clayton 1982 oral1,600-----3,128 ppm313 ppm
MouseClayton and Clayton 1982 oral1,600 ----- 3,128 ppm 313 ppm

Human data: Exposure to a concentration of 1,500 ppm was associated with complaints of ocular and upper respiratory irritation [Yant et al. 1936].

 

Revised IDLH: 1,500 ppm

Basis for revised IDLH: The revised IDLH for 2-pentanone is 1,500 ppm based on acute inhalation toxicity data in humans [Yant et al. 1936]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 1,500 ppm. Also, this value is 10% of the lower explosive limit of 1.5%.

REFERENCES:

1. Clayton GD, Clayton FE, eds. [1982]. Patty's industrial hygiene and toxicology. 3rd rev. ed. Vol. 2A. Toxicology. New York: John Wiley & Sons, Inc., p. 4735.

2. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1734.

3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA [1962]. Range-finding toxicity data: list VI. AMA Arch Ind Hyg Occup Med 23:95-107.

4. Yant WP, Patty FA, Schrenk HH [1936]. Acute response of guinea pigs to vapors of some new commercial organic compounds. IX. Pentanone (methyl propyl ketone). Public Health Rep 51:392-399.

 
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