Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)
CAS number: 107–49–3
NIOSH REL: 0.05 mg/m3 TWA [skin]
Current OSHA PEL: 0.05 mg/m3 TWA [skin]
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 0.004 ppm (0.47 mg/m3) TWA [skin]
Description of substance: Colorless to amber liquid with a faint, fruity odor.
LEL : . . Noncombustible Liquid
Original (SCP) IDLH: 10 mg/m3
Basis for original (SCP) IDLH: The chosen IDLH is based on the estimated oral lethal dose in man of 100 mg cited by Patty .
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal dose data:
|Adjusted LD||Derived value|
|Rat||Edson 1960||oral||-----||0.5||3.5 mg/m3||0.4 mg/m3|
|G. pig||Frawley et al. 1952||oral||-----||2.3||16 mg/m3||1.6 mg/m3|
|Mouse||Kamimura et al. 1963||oral||-----||3||21 mg/m3||2.1 mg/m3|
Human data: TEPP, a cholinesterase inhibitor, has been
judged to be twice as toxic as parathion; the American Conference
of Governmental Industrial Hygienists TLV for TEPP was based on
an analogy to parathion and was half that selected for parathion
[ACGIH 1986]. It has been reported that the lethal oral dose is
1.429 mg/kg [CDC 1956; Patty 1963]. [Note: An oral dose of
1.429 mg/kg is equivalent to a 70-kg worker being exposed
to 67 mg/m3 for 30 minutes assuming a 50 liter
per minute breathing rate and 100% absorption.]
|Revised IDLH: 5 mg/m3
Basis for revised IDLH: No inhalation data are available on which to base an IDLH for TEPP. Therefore, the revised IDLH for TEPP is 5 mg/m3 based on acute oral toxicity data in humans [CDC 1956; Patty 1963] and an analogy to parathion [ACGIH 1986] which has a revised IDLH of 10 mg/m3.
1. ACGIH . TEPP. In: Documentation of the threshold limit values and biological exposure indices. 5th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 558.
2. CDC . Clinical memoranda on economic poisons. Atlanta, GA: Communicable Disease Center, Bureau of State Services, Public Health Service, U.S. Department of Health, Education, and Welfare, Public Health Service Publication No. 476, pp. 21-23.
3. Edson EF . Applied toxicology of pesticides. Pharmaceut J 185:361-367.
4. Frawley JP, Hagan EC, Fitzhugh OG . A comparative pharmacological and toxicological study of organic phosphateÄanticholinesterase compounds. J Pharmacol Exp Ther 105:156-165.
5. Kamimura H, Matsumoto A, Miyazaki Y, Yamamoto I . Studies on nicotinoids as an insecticide. Part IV. Relation of structure to toxicity of pyridylmethylamines. Agri Biol Chem 27(10):684-688.
6. Patty FA, ed. . Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1956.
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