Allyl chloride

CAS number: 107-05-1

NIOSH REL: 1 ppm (3 mg/m3) TWA, 2 ppm (6 mg/m3) STEL

Current OSHA PEL: 1 ppm (3 mg/m3) TWA

1989 OSHA PEL: 1 ppm (3 mg/m3) TWA, 2 ppm (6 mg/m3) STEL

1993-1994 ACGIH TLV: 1 ppm (3 mg/m3) TWA, 2 ppm (6 mg/m3) STEL

Description of substance: Colorless, brown, yellow, or purple liquid with a pungent, unpleasant odor.

LEL: 2.9% (10% LEL, 2,900 ppm)

Original (SCP) IDLH: 300 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by Deichmann and Gerarde [1969] that a 1-hour exposure to 300 ppm might cause serious effects.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

					Adjusted
		LC50	LCLo		0.5-hr	Derived
Species	Reference	(ppm)	(ppm)	Time	LC (CF)	Value
Rat	Boqin et al. 1982	11,000 mg/m3	-----	2 hr	4,323 ppm (1.25)	434 ppm
Mouse	Boqin et al. 1982	11,500 mg/m3	-----	2 hr	4,520 ppm (1.25)	452 ppm
G. pig	Boqin et al. 1982	5,800 mg/m3	-----	2 hr	2,280 ppm (1.25)	228 ppm
Rabbit	Boqin et al. 1982	22,500 mg/m3	-----	2 hr	8,844 ppm (1.25)	884 ppm
Cat	Boqin et al. 1982	10,500 mg/m3	-----	2 hr	4,127 ppm (1.25)	413 ppm

Human data: It has been stated that a 1-hour exposure to 300 ppm might cause serious effects [Deichmann and Gerarde 1969].

Revised IDLH: 250 ppm Basis for revised IDLH: The revised IDLH for allyl chloride is 250 ppm based on acute inhalation toxicity data in humans [Deichmann and Gerarde 1969] and animals [Boqin et al. 1982].

References:

1. Boqin L, Shuwei D, Airu Y, Yinlin X, Taibao G, Tao C [1982]. Studies on the toxicity of allyl chloride. Ecotoxicol Environ Safety 6(1):19-27.
2. Deichmann WB, Gerarde HW [1969]. Allyl chloride. In: Toxicology of drugs and chemicals. New York, NY: Academic Press, Inc., pp. 86-87.