Xylidine
RTECS #
ZE8575000
CAS #
Updated
September 2013
Molecular Weight
121.20
Molecular Formula
C8H11N
Synonyms
Aminodimethylbenzene
Dimethylaminobenzene (OSHA)
Xilidine (Italian)
Xylidine (ACGIH:OSHA)
Xylidine (mixed isomers)
Xylidinen (Dutch)
Dimethylaminobenzene (OSHA)
Xilidine (Italian)
Xylidine (ACGIH:OSHA)
Xylidine (mixed isomers)
Xylidinen (Dutch)
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intravenous/cat | lowest published lethal dose: 120 mg/kg | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JIHTAB 31,1,1949 |
| intravenous/rabbit | lowest published lethal dose: 240 mg/kg | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JIHTAB 31,1,1949 |
| oral/rabbit | lethal dose (50 percent kill): 600 mg/kg | 34ZIAG -,637,1969 | |
| oral/rat | lowest published lethal dose: 610 mg/kg | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JIHTAB 31,1,1949 |
| skin/mouse | lethal dose (50 percent kill): 1670 mg/kg | GTPZAB 20(10),5,1976 | |
| skin/rabbit | lethal dose (50 percent kill): 1500 mg/kg | GTPZAB 20(10),5,1976 | |
| skin/rat | lethal dose (50 percent kill): 2 gm/kg | GTPZAB 20(10),5,1976 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.5 ppm (inhal, vapor, skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 5 ppm (25 mg/m3) (skin) | DTLVS* 3,282,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 5 ppm (25 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.5 ppm (2.5 mg/m3), Carcinogen, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 5 ppm (25 mg/m3), skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.5 ppm (2.5 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.5 ppm (2.5 mg/m3), skin, MAY2011 | |
| Occupational Exposure Limit-FRANCE | VME 2 ppm (10 mg/m3), Skin, FEB2006 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 25 mg/m3, Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.5 ppm (2.5 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 2 ppm (10 mg/m3), skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 0.5 ppm (25 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.5 ppm (2.5 mg/m3), skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 1 ppm (5 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 0,5 ppm (2,5 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 10 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 3 mg/m3, Skin, JUN2003 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 2.5 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 100 ppm (435 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 5 ppm (25 mg/m3), Skin, JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 5 ppm (25 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 5 ppm (25 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 5 ppm (25 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 5 ppm (25 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO XYLIDINE-air | 10H time-weighted average 2 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 76910; Number of Industries 8; Total Number of Facilities 432; Number of Occupations 11; Total Number of Employees Exposed 2319; Total Number of Female Employees Exposed 316 | |
| National Occupational Hazard Survey 1974 | Hazard Code 76910; Number of Industries 5; Total Number of Facilities 110; Number of Occupations 7; Total Number of Employees Exposed 1754 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health