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Xylidine

RTECS #: ZE8575000

CAS #: 1300-73-8


UPDATE: May 2009 MW: 121.20 MF: C8H11N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Aminodimethylbenzene
  2. Dimethylaminobenzene (OSHA)
  3. Xilidine (Italian)
  1. Xylidine (ACGIH:OSHA)
  2. Xylidine (mixed isomers)
  3. Xylidinen (Dutch)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
cat
lowest published lethal dose: 120 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JIHTAB 31,1,1949
intravenous
rabbit
lowest published lethal dose: 240 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JIHTAB 31,1,1949
oral
rat
lowest published lethal dose: 610 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JIHTAB 31,1,1949
oral
rabbit
lethal dose (50 percent kill): 600 mg/kg N/R 34ZIAG -,637,1969
skin
mouse
lethal dose (50 percent kill): 1,670 mg/kg N/R GTPZAB 20(10),5,1976
skin
rat
lethal dose (50 percent kill): 2 gm/kg N/R GTPZAB 20(10),5,1976
skin
rabbit
lethal dose (50 percent kill): 1,500 mg/kg N/R GTPZAB 20(10),5,1976


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm (inhalable, vapor; skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 ppm (25 mg/m3) (skin) DTLVS* 3,282,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (25 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (25 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (25 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (25 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 5 ppm (25 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 ppm (2.5 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 ppm (2.5 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (2.5 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 5 ppm (25 mg/m3), short term exposure limit 10 ppm (50 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 2 ppm (10 mg/m3), Skin, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 25 mg/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 2 ppm (10 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.5 ppm (25 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 2.5 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.5 ppm (2.5 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (435 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 10 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 3 mg/m3, Skin, JUN2003
Occupational Exposure Limit - TURKEY time-weighted average 5 ppm (25 mg/m3), Skin, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO XYLIDINE-air 10 hour time-weighted average 2 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 76910;
Number of Industries 5;
Total Number of Facilities 110;
Number of Occupations 7;
Total Number of Employees Exposed 1,754
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 76910;
Number of Industries 8;
Total Number of Facilities 432;
Number of Occupations 11;
Total Number of Employees Exposed 2,319;
Total Number of Female Employees Exposed 316


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a raw material in manufacture of dyes, pharmaceuticals and other organic compounds
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Amines, aromatic, 2002


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

Used as a raw material in manufacture of dyes, pharmaceuticals and other organic compounds

NIOSH PROFILE (ARENES), SRI, 2/77

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