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m - Xylene

RTECS #: ZE2275000

CAS #: 108-38-3


UPDATE: May 2009 MW: 106.18 MF: C8H10


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,3 - Dimethylbenzene
  2. 1,3 - Xylene
  3. Benzene, 1,3 - dimethyl - (9CI)
  4. m - Dimethylbenzene
  1. m - Methyltoluene
  2. m - Xylene (ACGIH:OSHA)
  3. m - Xylol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
5 mg/24 hour severe 85JCAE -,30,1986
skin
rat
1,00%/1 hour TOXID9 72,379,2003
skin
rabbit
10 g/24 hour open irritation test severe AIHAAP 23,95,1962
skin
rabbit
20 mg/24 hour moderate 85JCAE -,30,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage human fibroblast 0.34 mmol/L/1 hour TOLED5 147,35,2004


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 500 mg/m3/12 hour (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
ATSUDG 8,425,1985
inhalation
rat
lowest published toxic concentration: 3,000 mg/m3/24 hour (7-14 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXCYAC 18,61,1980
inhalation
rabbit
lowest published toxic concentration: 500 mg/m3/24 hour (7-20 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
ATSUDG 8,425,1985
oral
mouse
lowest published toxic dose: 12 mg/kg (12-15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) APTOD9 19,A22,1980
oral
mouse
lowest published toxic dose: 30 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) APTOD9 19,A22,1980


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 50 ppm/2 hour Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 60,428,2001
inhalation
mammal (species unspecified)
lowest published toxic concentration: 300 ppm Lung, Thorax, or Respiration: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOXID9 66,97,2002
inhalation
man
lowest published toxic concentration: 424 mg/m3/6 hour/6 day Behavioral: Change in motor activity (specific assay) TOLED5 1000(Sp Iss 1),74,1980
inhalation
man
lowest published toxic concentration: 870 mg/m3/4 hour- intermittent Behavioral: Ataxia

Behavioral: Irritability
ATSUDG 7,412,1984
inhalation
mouse
lowest published lethal concentration: 2,010 ppm/24 hour N/R JPBAA7 46,95,1938
inhalation
mouse
lethal concentration (50 percent kill): 5,267 ppm/6 hour N/R VCVGH* -,159,1990
inhalation
rat
lowest published lethal concentration: 8,000 ppm/4 hour N/R AIHAAP 23,95,1962
inhalation
rat
lowest published toxic dose: 100 ppm/6 hour Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
INHTE5 16,125,2004
inhalation
rat
lowest published toxic dose: 300 ppm/6 hour Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects INHTE5 16,125,2004
inhalation
rat
lowest published toxic concentration: 100 ppm/6 hour Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
INHTE5 16,125,2004
inhalation
rat
lowest published toxic concentration: 300 ppm/6 hour Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects INHTE5 16,125,2004
intraperitoneal
mammal (species unspecified)
lowest published lethal dose: 2 gm/kg N/R JPBAA7 46,95,1938
intraperitoneal
mouse
lethal dose (50 percent kill): 2,003 L/kg N/R ARTODN 58,106,1985
oral
rat
lethal dose (50 percent kill): 4,988 mg/kg N/R VCVGH* -,160,1990
subcutaneous
mammal (species unspecified)
lowest published lethal dose: 5 gm/kg N/R JPBAA7 46,95,1938
skin
guinea pig
lowest published toxic dose: 500 L/kg/1 hour Skin: After topical application: Primary irritation TOXID9 1,59,2001
skin
rat
lowest published toxic dose: 0.92 mL/kg Skin: After topical application: Primary irritation

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation

Biochemical: Metabolism (intermediary): Other proteins
ARTODN 79,294,2005
skin
rat
lowest published toxic dose: 1,250 L/kg/1 hour Skin: After topical application: Primary irritation TOXID9 1,59,2001
skin
rabbit
lethal dose (50 percent kill): 14,100 L/kg N/R AIHAAP 23,95,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 400 ppm/6 hour/2 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
ARTODN 45,117,1980
inhalation
rat
lowest published toxic concentration: 100 ppm/6 hour/20 day- intermittent Behavioral: Analgesia

Behavioral: Alteration of operant conditioning

Behavioral: Alteration of classical conditioning
NRTXDN 22,79,2001
inhalation
rat
lowest published toxic concentration: 1,000 ppm/6 hour/8 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Behavioral: Food intake (animal)
FCTOD7 41,415,2003
oral
rat
lowest published toxic dose: 10 gm/kg/4 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TIHEEC 1(3),67,1985
skin
rat
lowest published toxic dose: 0.96 mL/kg/4 day- intermittent Skin: After topical application: Primary irritation

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation

Biochemical: Metabolism (intermediary): Other proteins
ARTODN 79,294,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 100 ppm;short term exposure limit 150 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 71,1189,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,1189,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1189,1999
TOXICOLOGY REVIEW
TOLED5 127,111,2002
TOXICOLOGY REVIEW
ENTOX* -,470,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (440 mg/m3) (skin) DTLVS* 3,281,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (435 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (435 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (435 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (435 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 80 ppm (350 mg/m3), short term exposure limit 150 ppm (655 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (221 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 100 ppm (442 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (109 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 221 mg/m3 (50 ppm);
short term exposure limit 442 mg/m3 (skin), FEB 2006
Occupational Exposure Limit - FRANCE VME 50 ppm (221 mg/m3), VLE 100 ppm (442 mg/m3), Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 440 mg/m3 (100 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 221 mg/m3, short term exposure limit 442 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 50 ppm (217 mg/m3), APR2007
Occupational Exposure Limit - MEXICO time-weighted average 100 ppm (435 mg/m3);
short term exposure limit 150 ppm (655 mg/m3), 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 50 ppm (217 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (108 mg/m3), JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 50 ppm (200 mg/m3);
short term exposure limit 100 ppm (450 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 100 ppm (435 mg/m3),KZG- week 200 ppm (870 mg/m3),Skin, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (220 mg/m3);
short term exposure limit 100 ppm (skin), 2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO m-XYLENE-air 10 hour time-weighted average 100 ppm;
short term exposure limit 150 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1027;
Number of Industries 5;
Total Number of Facilities 96;
Number of Occupations 21;
Total Number of Employees Exposed 4,621
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1027;
Number of Industries 33;
Total Number of Facilities 4,113;
Number of Occupations 36;
Total Number of Employees Exposed 39,864;
Total Number of Female Employees Exposed 7,449


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as intermediate in preparation of ISOPHTHALIC ACID
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #1002


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
JPBAA7 Journal of Pathology and Bacteriology. (London, UK) V.1-96, 1892-1968. For publisher information, see JPTLAS.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as intermediate in preparation of ISOPHTHALIC ACID

RTECS Compound Description:
   Tumorigen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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