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Turpentine

RTECS #: YO8400000

CAS #: 8006-64-2


UPDATE: May 2009 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Essential oils, turpentine
  2. G 4134
  3. Gum spirits of turpentine
  4. Gum turpentine
  5. Oil of turpentine
  6. Oil of turpentine, rectified
  7. Spirit of turpentine
  8. Spirits of turpentine
  1. Terebenthine (French)
  2. Terpentin oel (German)
  3. Turpentine oil, rectifier
  4. Turpentine steam distilled
  5. Turpentine (ACGIH:OSHA)
  6. Turpentine oil
  7. Wood turpentine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
human
175 ppm N/R JIHTAB 25,282,1943
skin
rabbit
500 L severe NTIS** OTS0545856


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
mouse
lowest published toxic dose: 240 gm/kg/20 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
CNREA8 19,413,1959


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published lethal concentration: 16 gm/m3/1 hour N/R 85GMAT -,119,1982
inhalation
human
lowest published toxic concentration: 175 ppm Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes
JIHTAB 25,282,1943
inhalation
human
lowest published toxic concentration: 6 gm/m3/3 hour Eye: Other eye effects

Behavioral: Hallucinations, distorted perceptions

Behavioral: Headache
AHYGAJ 83,239,1914
inhalation
human
lowest published toxic concentration: 700 mg/m3/15 minute Behavioral: Headache

Cardiac: Pulse rate increased without fall in BP

Gastrointestinal: Nausea or vomiting
VCVPS* -,291,1998
inhalation
human
lowest published toxic concentration: 4,000 mg/m3/1 hour Behavioral: Somnolence (general depressed activity)

Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Respiratory depression
VCVPS* -,291,1998
inhalation
man
lowest published toxic concentration: 449 mg/m3/2 hour Lung, Thorax, or Respiration: Other changes OEMEEM 53,100,1996
inhalation
mouse
lethal concentration (50 percent kill): 29 mg/m3/2 hour Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
TXAPA9 6,360,1964
inhalation
mouse
lethal concentration (50 percent kill): 30,000 mg/m3 Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
VCVPS* -,291,1998
inhalation
rat
lethal concentration (50 percent kill): 12 gm/m3/6 hour Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
TXAPA9 10,8,1967
inhalation
rat
lethal concentration (50 percent kill): 16,600 mg/m3/2 hour Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
VCVPS* -,291,1998
inhalation
rat
lethal concentration (50 percent kill): 13,700 mg/m3/4 hour Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVPS* -,291,1998
inhalation
rat
lethal concentration (50 percent kill): 12 gm/m3 N/R ENTOX* -,394,2005
intravenous
man
lowest published toxic dose: 71 L/kg Peripheral Nerve and Sensation: Associated connective tissue

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
AJEMEN 4,543,1986
intravenous
mouse
lethal dose (50 percent kill): 1,180 g/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
TXAPA9 6,360,1964
oral
infant
lowest published lethal dose: 1,748 mg/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Other changes
ADCHAK 28,475,1953
oral
infant
lowest published toxic dose: 874 mg/kg Behavioral: Antipsychotic ADCHAK 28,475,1953
oral
man
lowest published lethal dose: 2,857 L/kg Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Other changes
FSINDR 65,47,1994
oral
man
lowest published lethal dose: 3 mg/kg Behavioral: Muscle weakness

Gastrointestinal: Other changes
BMJOAE 2,77,1931
oral
rat
lethal dose (50 percent kill): 5,760 mg/kg N/R ENTOX* -,394,2005
oral
woman
lowest published toxic dose: 560 mg/kg Kidney, Ureter, and Bladder: Other changes ADCHAK 28,475,1953
subcutaneous
rat
lowest published toxic dose: 1 mL/kg Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins
TOLED5 147,153,2004
skin
rabbit
lowest published lethal dose: 5,010 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0545856
unreported route
human
lowest published lethal dose: 1,777 mg/kg N/R FSINDR 65,47,1994
unreported route
man
lowest published lethal dose: 441 mg/kg N/R 85DCAI 2,73,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 20 ppm (sen) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
BLFSBY 24,253,1983
TOXICOLOGY REVIEW
TOLED5 128,85,2002
TOXICOLOGY REVIEW
ENTOX* -,394,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled/New AI RBREV* -,280,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (560 mg/m3) DTLVS* 3,274,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (560 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (560 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (560 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (560 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 100 ppm (557 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 20 ppm ( mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (140 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 100 ppm (560 mg/m3), short term exposure limit 150 ppm, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 100 ppm (560 mg/m3), FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 560 mg/m3, short term exposure limit 560 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 50 ppm (280 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 100 ppm (560 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 100 ppm (560 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 560 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 100 ppm (556 mg/m3), sen, JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (560 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 300 mg/m3, MAC(short term exposure limit) 840 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 300 mg( continuous)/m3, short term exposure limit 600 mg( continuous)/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 100 ppm (560 mg/m3),KZG- week 100 ppm (560 mg/m3),DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 100 ppm (560 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 100 ppm (566 mg/m3);
short term exposure limit 150 ppm, 2005
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TURPENTINE-air 10 hour time-weighted average 100 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 74990;
Number of Industries 139;
Total Number of Facilities 12,405;
Number of Occupations 92;
Total Number of Employees Exposed 113,949
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5757;
Number of Industries 75;
Total Number of Facilities 7,231;
Number of Occupations 62;
Total Number of Employees Exposed 116,433;
Total Number of Female Employees Exposed 22,205
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 74990;
Number of Industries 146;
Total Number of Facilities 19,493;
Number of Occupations 94;
Total Number of Employees Exposed 351,747;
Total Number of Female Employees Exposed 144,051


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as paint thinner, solvent for various resins, polishes and waxes
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9158
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Turpentine, 1551
NIOSH Analytical Method, 1996: Volatile organic compound, 2549


REFERENCES:

CODEN
REFERENCE

85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
ADCHAK Archives of Disease in Childhood. (British Medical Journal, POB 560B, Kennebunkport, ME 04046) V.1- 1926-
AHYGAJ Archiv fuer Hygiene. (Munich, Fed. Rep. Ger.) V.1-100, 1883-1928. For publisher information, see ZHPMAT.
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973-
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FSINDR Forensic Science International. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.12- 1978-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
OEMEEM Occupational and Environmental Medicine. (BMJ Publishing Group, POB 299, London WC1H 9TD, United Kingdom) V.51- 1994-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVPS* "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.

Used as paint thinner, solvent for various resins, polishes and waxes

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), FIRL, 4/78

NIOSH PROFILE (SPRAY PAINTING), FIRL, 4/78

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), SRI, 2/7

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen
   Human Data
   Natural Product
   Primary Irritant

ALT CAS #: 8052-40-2
Click Here for Additional Information about RTECS

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