CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






as - Triazin - 5 (4H) - one, 4 - amino - 6 - tert - butyl - 3 - (methylthio) -

RTECS #: XZ2990000

CAS #: 21087-64-9


UPDATE: May 2009 MW: 214.32 MF: C8H14N4OS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,2,4 - Triazin - 5 (4H) - one, 4 - amino - 6 - (1,1 - dimethylethyl) - 3 - (methylthio) -
  2. 1,2,4 - Triazin - 5 - one, 4 - amino - 6 - tert - butyl - 3 - (methylthio) -
  3. 4 - Amino - 6 - (1,1 - dimethylethyl) - 3 - (methylthio) - 1,2,4 - triazin - 5 (4H) - one
  4. 4 - Amino - 6 - tert - butyl - 3 - (methylthio) - 1,2,4 - triazin - 5 - one
  5. 4 - Amino - 6 - tert - butyl - 3 - methylthio - as - triazin - 5 - one
  6. BAY 61597
  7. BAY dic 1468
  8. Bayer 6159H
  9. Bayer 6443H
  10. Bayer 94337
  11. DIC 1468
  12. Lexone
  1. Lexone 4L
  2. Lexone DF
  3. Metribuzin
  4. Metribuzin (ACGIH)
  5. NTN 70
  6. Sencor
  7. Sencor 4
  8. Sencor DF
  9. Sencoral
  10. Sencorer
  11. Sencorex
  12. Zenkor


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 1 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) NNGADV 12,127,1987


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration : >860 mg/m3/4 hour N/R 85INA8 6,1042,1991
inhalation
rat
lethal concentration (50 percent kill): >860 mg/m3/4 hour N/R NNGADV 12,127,1987
intraperitoneal
mouse
lethal dose (50 percent kill): 210 mg/kg Behavioral: Somnolence (general depressed activity) PCBPBS 23,123,1984
intraperitoneal
rat
lethal dose (50 percent kill): 239 mg/kg N/R NNGADV 12,127,1987
oral
cat
lethal dose (50 percent kill): >500 mg/kg N/R 85JFAN A280,1983
oral
guinea pig
lethal dose (50 percent kill): 250 mg/kg N/R 85DPAN -,-,1971/1976
oral
mouse
lethal dose (50 percent kill): 564 mg/kg N/R NNGADV 12,127,1987
oral
quail
lethal dose (50 percent kill): 164 mg/kg N/R PEMNDP 8,573,1987
oral
rat
lethal dose (50 percent kill): 1,100 mg/kg N/R FMCHA2 -,C204,1991
subcutaneous
mouse
lethal dose (50 percent kill): 367 mg/kg N/R NNGADV 12,127,1987
subcutaneous
rat
lethal dose (50 percent kill): 814 mg/kg N/R NNGADV 12,127,1987
skin
mouse
lethal dose (50 percent kill): >1 gm/kg N/R NNGADV 12,127,1987
skin
rat
lethal dose (50 percent kill): 2 gm/kg N/R 85JCAE -,1001,1986
skin
rabbit
lethal dose (50 percent kill): >20 gm/kg N/R FMCHA2 -,C204,1991
unreported route
quail
lethal dose (50 percent kill): 168 mg/kg N/R FMCHA2 -,C204,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 27,375 mg/kg/2 year- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NNGADV 12,127,1987
oral
dog
lowest published toxic dose: 27.3 gm/kg/104 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1512,2001
oral
mouse
lowest published toxic dose: 65.7 gm/kg/78 week- continuous Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight

Blood: Other changes
HBPTO* 2,1514,2001
oral
rat
lowest published toxic dose: 64,800 g/kg/15 week- continuous Brain and Coverings: Other degenerative changes JTEHD6 30,209,1990
oral
rat
lowest published toxic dose: 4,550 mg/kg/26 week- intermittent Immunological Including Allergic: Increased immune response GISAAA 52(11),76,1987
oral
rat
lowest published toxic dose: 13,140 mg/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NNGADV 12,127,1987
oral
rat
lowest published toxic dose: 10.92 gm/kg/104 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1512,2001
oral
rat
lowest published toxic dose: 10.95 gm/kg/2 year- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1514,2001
oral
rat
lowest published toxic dose: 10.95 gm/kg/2 year- continuous Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)
HBPTO* 2,1514,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
JTEHD6 7,1,2004
TOXICOLOGY REVIEW
FEREAC 71,43906,2006
TOXICOLOGY REVIEW
FEREAC 72,39318,2007
TOXICOLOGY REVIEW
FEREAC 72,39318,2007
TOXICOLOGY REVIEW
JTPAE7 19,1,2006
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,133,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, OCT 2002
Occupational Exposure Limit - FRANCE VME 5 mg/m3, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 5 mg/m3, 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METRIBUZIN-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
Used for control of a large number of grass and broadleaf weeds infesting agricultural crops
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HTOPA*
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998

Used for control of a large number of grass and broadleaf weeds infesting agricultural crops

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us