CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Toluene, m - nitro -

RTECS #: XT2975000

CAS #: 99-08-1


UPDATE: May 2009 MW: 137.15 MF: C7H7NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Methyl - 3 - nitrobenzene
  2. 3 - Methylnitrobenzene
  3. 3 - Nitrotoluene
  4. 3 - Nitrotoluol
  5. Benzene, 1 - methyl - 3 - nitro - (9CI)
  6. MNT
  1. Nitrotoluene, meto -
  2. m - Methylnitrobenzene
  3. m - Nitrotoluene
  4. m - Nitrotoluene (ACGIH:OSHA)
  5. meta - Nitrotoluol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
sister chromatid exchange hamster ovary 115 mg/L EMMUEG 10(Suppl 10),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 31,122 mg/kg (13 week prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders NTPTR* NIH-93-3346
oral
rat
lowest published toxic dose: 60,151 mg/kg (13 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
NTPTR* NIH-93-3346


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 425 mg/m3 Brain and Coverings: Recordings from specific areas of CNS

Liver: Fatty liver degeneration

Blood: Methemoglobinemia- Carboxhemoglobinemia
GTPZAB 22(7),52,1978
inhalation
rat
lethal concentration (50 percent kill): 693 mg/m3 Brain and Coverings: Recordings from specific areas of CNS

Liver: Fatty liver degeneration

Blood: Methemoglobinemia- Carboxhemoglobinemia
GTPZAB 22(7),52,1978
oral
guinea pig
lethal dose (50 percent kill): 3,600 mg/kg N/R CHABA8 73,91015e,1970
oral
mouse
lethal dose (50 percent kill): 330 mg/kg N/R CHABA8 73,91015e,1970
oral
rat
lethal dose (50 percent kill): 1,072 mg/kg N/R NTIS** PB214-270
oral
rabbit
lethal dose (50 percent kill): 1,750 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Liver: Fatty liver degeneration

Blood: Methemoglobinemia- Carboxhemoglobinemia
GTPZAB 22(7),52,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lowest published toxic concentration: 30 mg/m3/4 hour/17 week- intermittent Kidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Other changes in urine composition
GTPZAB 22(7),52,1978
oral
mouse
lowest published toxic dose: 67,613 mg/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Changes in testicular weight
NTPTR* NIH-93-3346
oral
mouse
lowest published toxic dose: 5,600 mg/kg/14 day- intermittent Endocrine: Changes in thymus weight

Blood: Changes in other cell count (unspecified)
DCTODJ 17,359,1994
oral
rat
lowest published toxic dose: 31,122 mg/kg/13 week- continuous Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in platelet count

Related to Chronic Data: Changes in testicular weight
NTPTR* NIH-93-3346


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm (skin) DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 65,409,1996
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 65,409,1996
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 65,409,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (30 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (30 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (30 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (30 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (11 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (11 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (12 mg/m3), OCT 2002
Occupational Exposure Limit - FRANCE VME 2 ppm (11 mg/m3), Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 28 mg/m3 (5 mL/m3), 2005
Occupational Exposure Limit - MEXICO time-weighted average 5 ppm (30 mg/m3);
short term exposure limit 10 ppm (60 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 6 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2 ppm (11 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (5.5 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 3 mg/m3, MAC(short term exposure limit) 9 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 1 ppm (6 mg/m3);
short term exposure limit 2 ppm (11 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (11 mg/m3),KZG- week 4 ppm (22 mg/m3), Skin,DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 2 ppm (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 2 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO m-NITROTOLUENE-air 10 hour time-weighted average 2 ppm (Sk) NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Toxicity studies, RPT# TOX-23, October 2000


REFERENCES:

CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHABA8 Chemical Abstracts. (Chemical Abstracts Service, Box 3012, Columbus, OH 43210) V.1- 1907-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-

NIOSH PROFILE (NITROTOLUENES), SRC, 10/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us