Thiopyrophosphoric acid, tetraethyl ester

RTECS #

XN4375000

CAS #

3689-24-5
See: NMAM or OSHA Methods

Updated

December 2015

Molecular Weight

322.34

Molecular Formula

C₈H₂₀O₅P₂S₂

Synonyms

ASP 47
BAY-E-393
Bayer-E 393
Bis-O,O-diethylphosphorothionic anhydride
Bladafum
Di(thiophosphoric) acid, tetraethyl ester
Dithiodiphosphoric acid, tetraethyl ester
Dithiofos
Dithiophos
Dithiopyrophosphate de tetraethyle (French)
Dithiotep
E393
ENT 16,273
Ethyl thiopyrophosphate ((EtO)2(PS)2O)
Lethalaire G-57
O,O,O,O-Tetraaethyl-dithionopyrophosphat (German)
O,O,O,O-Tetraethyl dithiopyrophosphate
O,O,O,O-Tetraethyl-dithio-difosfaat (Dutch)
O,O,O,O-Tetraetil-ditio-pirofosfato (Italian)
Plantfume 103 smoke generator
Pyrophosphorodithioic acid, O,O,O,O-tetraethyl ester
Pyrophosphorodithioic acid, tetraethyl ester
RCRA waste number P109
Sulfotep
Sulfotep (ACGIH:OSHA)
Sulfotepp
TEDP (OSHA)
TEDTP
Tetraethyl dithionopyrophosphate
Tetraethyl dithiopyrophosphate
Tetraethyldithiodifosfat (Czech)
Thiodiphosphoric acid tetraethyl ester
Thiotepp

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
mutation in microorganisms	/Salmonella typhimurium	1 mg/plate (-enzymatic activation step)	EMMUEG 11(Suppl 12),1,1988

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lethal concentration (50 percent kill): 40 mg/m³/4H	Autonomic Nervous System: Other (direct) parasympathomimetic	ARTODN 33,1,1974
inhalation/rat	lethal concentration (50 percent kill): 38 mg/m³/4H	Autonomic Nervous System: Other (direct) parasympathomimetic	ARTODN 33,1,1974
intramuscular/mouse	lethal dose (50 percent kill): 500 µg/kg		CJCHAG 34,1819,1956
intramuscular/rat	lethal dose (50 percent kill): 55 µg/kg		CJCHAG 34,1819,1956
intraperitoneal/chicken	lethal dose (50 percent kill): 25 mg/kg	Autonomic Nervous System: Other (direct) parasympathomimetic Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	ARTODN 33,1,1974
intraperitoneal/mouse	lethal dose (50 percent kill): 940 µg/kg		CJCHAG 34,1819,1956
intraperitoneal/rat	lethal dose (50 percent kill): 6600 µg/kg	Autonomic Nervous System: Other (direct) parasympathomimetic	ARTODN 33,1,1974
intravenous/mouse	lethal dose (50 percent kill): 300 µg/kg		CJCHAG 34,1819,1956
oral/cat	lethal dose (50 percent kill): 3 mg/kg	Autonomic Nervous System: Other (direct) parasympathomimetic	ARTODN 33,1,1974
oral/chicken	lethal dose (50 percent kill): 25 mg/kg	Autonomic Nervous System: Other (direct) parasympathomimetic Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	ARTODN 33,1,1974
oral/Dog	lethal dose (50 percent kill): 5 mg/kg	Autonomic Nervous System: Other (direct) parasympathomimetic	ARTODN 33,1,1974
oral/mouse	lethal dose (50 percent kill): 22 mg/kg	Autonomic Nervous System: Other (direct) parasympathomimetic	ARTODN 33,1,1974
oral/rabbit	lethal dose (50 percent kill): 25 mg/kg	Autonomic Nervous System: Other (direct) parasympathomimetic	ARTODN 33,1,1974
oral/rat	lethal dose (50 percent kill): 5 mg/kg		ARSIM* 20,24,1966
oral/wild bird	lethal dose (50 percent kill): 100 mg/kg		TXAPA9 21,315,1972
skin/rabbit	lethal dose (50 percent kill): 20 mg/kg		WRPCA2 9,119,1970
skin/rat	lethal dose (50 percent kill): 65 mg/kg	Autonomic Nervous System: Other (direct) parasympathomimetic	ARTODN 33,1,1974
subcutaneous/mouse	lethal dose (50 percent kill): 8 mg/kg		PAREAQ 11,636,1959

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 2830 µg/m³/6H/12W- intermittent	Lung, Thorax, or Respiration: Other changes Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	ARTODN 33,1,1974
oral/rat	lowest published toxic dose: 91 mg/kg/13W- continuous	Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	ARTODN 33,1,1974

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.1 mg/m³ (inhal, vapor, skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		RREVAH 46,1,1973
TOXICOLOGY REVIEW		MUREAV 726,91,2011
TOXICOLOGY REVIEW		MUREAV 746,89,2012
TOXICOLOGY REVIEW		TOLED5 230,434,2014

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Supported	RBREV* -,149,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.2 mg/m³	DTLVS* 3,244,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.007 ppm (0.1 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.0075 ppm (0.1 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.1 mg/m³, Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.008 ppm (0.1 mg/m³), skin, MAY2011
Occupational Exposure Limit-EC	time-weighted average 0.1 mg/m³, skin, JUN2000
Occupational Exposure Limit-FINLAND	time-weighted average 0.1 mg/m³, skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 0.1 mg/m³, Skin, FEB2006
Occupational Exposure Limit-GERMANY	MAK 0.01 ppm (0.13 mg/m³), skin, 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 0.1 mg/m³, short term exposure limit 0.4 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 0.015 ppm (0.1 mg/m³), skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 0.2 mg/m³, skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.2 mg/m³;short term exposure limit 0.6 mg/m³ (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.2 mg/m³, skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.015 ppm (0.2 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0,1 mg/m³, JUL2005
Occupational Exposure Limit-SWEDEN	time-weighted average 0.1 mg/m³, Skin, JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.0075 ppm (0.1 mg/m³), KZG-week 0.015 ppm (0.2 mg/m³), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.1 mg/m³, Skin, 2003
Occupational Exposure Limit-TURKEY	time-weighted average 0.2 mg/m³, Skin, JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 0.1 mg/m³, skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.2 mg/m³ (skin)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.2 mg/m³ (skin)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.2 mg/m³ (skin)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.2 mg/m³ (skin)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TEDP-air	10H time-weighted average 0.2 mg/m³ (Sk)	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 82116; Number of Industries 5; Total Number of Facilities 674; Number of Occupations 8; Total Number of Employees Exposed 8085; Total Number of Female Employees Exposed 27

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8874
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health