CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Sucrose

RTECS #: WN6500000

CAS #: 57-50-1


UPDATE: May 2009 MW: 342.34 MF: C12H22O11


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. (alpha - D - Glucosido) - beta - D - fructofuranoside
  2. Beet sugar
  3. CANE sugar
  4. Confectioner's sugar
  5. Fructofuranoside, alpha - D - glucopyranosyl, beta - D
  6. Glucopyranoside, beta - D - fructofuranosyl, alpha - D
  7. Granulated sugar
  8. NCI - C56597
  1. Rock candy
  2. Saccharose
  3. Saccharum
  4. Sucrose (ACGIH:OSHA)
  5. Sugar
  6. alpha - D - Glucopyranosyl beta - D - fructofuranoside
  7. beta - D - Fructofuranoside, alpha - D - glucopyranosyl


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 10 gm/L ATSUDG 4,41,1980
cytogenetic analysis hamster ovary 275 mmol/L MUREAV 189,15,1987
DNA repair Saccharomyes cerevisiae 300 mg/L PMRSDJ 1,502,1981
mutation in microorganisms Salmonella typhimurium 600 g/plate (-enzymatic activation step) PMRSDJ 1,343,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mammal (species unspecified)
lowest published toxic dose: 54,810 mg/kg (15-35 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TJADAB 30,203,1984
oral
rat
lowest published toxic dose: 1,548 gm/kg (21 day prior to copulation/1-22 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system IJMDAI 16,789,1980
oral
rat
lowest published toxic dose: 683 gm/kg (1-21 day pregnant) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
AJCNAC 28,1416,1975
oral
rat
lowest published toxic dose: 683 gm/kg (21 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) AJCNAC 28,1416,1975


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 14,000 mg/kg N/R PCJOAU 15,139,1981
oral
domestic animal
lowest published lethal dose: 40 gm/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Hypermotility, diarrhea
NAREA4 30,503,1960
oral
human
lowest published toxic dose: 0.96 g/kg Behavioral: Analgesia APHRER 39,1029,2005
oral
mouse
lowest published toxic dose: 2 mg/kg Endocrine: Hyperglycemia JPHSC* 104,29,2007
oral
rat
lethal dose (50 percent kill): 29,700 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 7,609,1965


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 2,730 gm/kg/2 week- continuous Cardiac: Other changes

Nutritional and Gross Metabolic: Changes in: Other metals

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
LIFSAK 71,1303,2002
oral
rat
lowest published toxic dose: 700,000 mg/kg/35 day- continuous Gastrointestinal: Other changes FCTOD7 46,752,2008
oral
rat
lowest published toxic dose: 1,050 gm/kg/10 week- intermittent Endocrine: Hyperglycemia

Endocrine: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
JPHSC* 102,213,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 mg/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
HTOPA* 1,595,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD NUISANCE PARTICULATES DTLWS* 3,28,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3, respirable dust CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3, respirable dust CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3, respirable dust CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 mg/m3, respirable dust CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - BELGIUM time-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit - FRANCE VME 10 mg/m3, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 10 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 mg/m3;
short term exposure limit 20 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 mg/m3 (inspirable dust), JAN2002
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 mg/m3;
short term exposure limit 20 mg/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SUCROSE, respirable fraction-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SUCROSE, total dust-air 10 hour time-weighted average 10 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81515;
Number of Industries 101;
Total Number of Facilities 12,044;
Number of Occupations 86;
Total Number of Employees Exposed 121,005
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81515;
Number of Industries 108;
Total Number of Facilities 15,179;
Number of Occupations 110;
Total Number of Employees Exposed 368,912;
Total Number of Female Employees Exposed 169,962


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as sweetening agent, food, in pharmacy as a preservative and in the manufacture of ink
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AJCNAC American Journal of Clinical Nutrition. (American Soc. for Clinical Nutrition, Inc., 9650 Rockville Pike, Bethesda, MD 20814) V.2- 1954-
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
HTOPA*
IJMDAI Israel Journal of Medical Sciences. (POB 1435, Jerusalem 91013, Israel) V.1- 1965-
JPHSC*
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NAREA4 Nutrition Abstracts and Reviews. (Slough, UK) V.1-46, 1931-76.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967-
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as sweetening agent, food, in pharmacy as a preservative and in the manufacture of ink

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us