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Succinonitrile, tetramethyl -

RTECS #: WN4025000

CAS #: 3333-52-6


UPDATE: May 2009 MW: 136.22 MF: C8H12N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2,2,3,3 - Tetramethylbutanedinitrile
  2. Butanedinitrile, tetramethyl - (9CI)
  3. CP 75475
  4. TMSN
  5. Tetramethyl succinonitrile
  6. Tetramethyl succinonitrile (ACGIH:OSHA)
  1. Tetramethylbutanedinitrile
  2. Tetramethylsuccinic acid dinitrile
  3. Tetramethylsuccinodinitrile
  4. Tetramethylsuccinonitrile
  5. Tetramethylsukcinonitril (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
hamster
lowest published toxic dose: 9,944 g/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FAATDF 3,41,1983


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lethal concentration : >281 mg/m3/2 hour N/R ATXKA8 16,367,1957
inhalation
mouse
lowest published lethal concentration: 125 mg/m3/2 hour Behavioral: Convulsions or effect on seizure threshold ATXKA8 16,367,1957
inhalation
rat
lowest published lethal concentration: 60 ppm/2 hour N/R FEPRA7 8,205,1949
intraperitoneal
mouse
lethal dose (50 percent kill): 17,710 g/kg Behavioral: Convulsions or effect on seizure threshold JPETAB 223,635,1982
intraperitoneal
rat
lethal dose (50 percent kill): 17,500 g/kg N/R ATXKA8 16,367,1957
intravenous
mouse
lethal dose (50 percent kill): 18 mg/kg N/R CSLNX* NX#00002
intravenous
rabbit
lethal dose (50 percent kill): 20 mg/kg N/R FEPRA7 8,205,1949
oral
guinea pig
lethal dose (50 percent kill): 17,500 g/kg N/R ATXKA8 16,367,1957
oral
rat
lethal dose (50 percent kill): 27 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Pulmonary emboli
NTIS** OTS0555206
oral
rabbit
lowest published lethal dose: 25 mg/kg Behavioral: Convulsions or effect on seizure threshold ATXKA8 16,367,1957
subcutaneous
dog
lowest published lethal dose: 20 mg/kg N/R FEPRA7 8,205,1949
subcutaneous
guinea pig
lethal dose (50 percent kill): 23 mg/kg N/R FEPRA7 8,205,1949
subcutaneous
mouse
lowest published lethal dose: 30 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes
ATXKA8 16,367,1957
subcutaneous
rat
lethal dose (50 percent kill): 30 mg/kg N/R FEPRA7 8,205,1949
subcutaneous
rabbit
lowest published lethal dose: 30 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes
ATXKA8 16,367,1957
skin
rabbit
lowest published lethal dose: 79,400 g/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Pulmonary emboli
NTIS** OTS0555206


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 270 mg/kg/90 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 7,41,1986


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm (skin) DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 ppm (3 mg/m3) (skin) DTLVS* 3,254,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 ppm (3 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 ppm (3 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 ppm (3 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 ppm (3 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 ppm (2.8 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 ppm (2.8 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (3 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.5 ppm (3 mg/m3), short term exposure limit 1.5 ppm (8.4 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.5 ppm (3 mg/m3), Skin, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 0.5 ppm (3 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.5 ppm (3 mg/m3);
short term exposure limit 2 ppm (9 mg/m3) (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 3 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.5 ppm (2.8 mg/m3), skin, JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 ppm (3 mg/m3), Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 ppm (3 mg/m3),KZG- week 1 ppm (6 mg/m3), Skin,DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.5 ppm (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.5 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRAMETHYL SUCCINONITRILE-air 10 hour time-weighted average 0.5 ppm (Sk) NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

Used as a propellant gas in the production of polyvinyl foams

RTECS Compound Description:
   Reproductive Effector

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