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Resorcinol

RTECS #: VG9625000

CAS #: 108-46-3


UPDATE: May 2009 MW: 110.12 MF: C6H6O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,3 - Benzenediol
  2. 1,3 - Dihydroxybenzene
  3. 3 - Hydroxycyclohexadien - 1 - one
  4. 3 - Hydroxyphenol
  5. Benzene, m - dihydroxy -
  6. C.I. 76505
  7. C.I. Developer 4
  8. C.I. Oxidation Base 31
  9. Developer O
  10. Developer R
  11. Developer RS
  12. Durafur developer G
  13. Fouramine RS
  14. Fourrine 79
  15. Fourrine EW
  1. NCI - C05970
  2. Nako TGG
  3. Pelagol Grey RS
  4. Pelagol RS
  5. Phenol, m - hydroxy -
  6. RCRA waste number U201
  7. Resorcin
  8. Resorcine
  9. Resorcinol (ACGIH)
  10. m - Benzenediol
  11. m - Dihydroxybenzene
  12. m - Dioxybenzene
  13. m - Hydroquinone
  14. m - Hydroxyphenol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 mg N/R IHFCAY 6,1,1967
skin
rabbit
20 mg/24 hour moderate 85JCAE -,234,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 1,600 mg/L CALEDQ 14,251,1981
cytogenetic analysis human lymphocyte 80 mg/L ARZNAD 32,533,1982
cytogenetic analysis human other cell types 40 mg/L ARZNAD 32,533,1982
cytogenetic analysis human lymphocyte 0.2 pph VCVGK* -,227,1994
DNA damage human mammary gland 50 mg/L/24 hour (-enzymatic activation step) MUREAV 588,47,2005
DNA damage rat liver 10 mmol/L CALEDQ 63,47,1992
mutation in microorganisms Salmonella typhimurium 20 Ámol/plate (+/-enzymatic activation step) MUREAV 90,91,1981
micronucleus test hamster ovary 186 mg/L/24 hour (-enzymatic activation step) MUREAV 582,116,2005
micronucleus test hamster ovary 372 mg/L/3 hour (+enzymatic activation step) MUREAV 582,116,2005
gene conversion and mitotic recombination Saccharomyes cerevisiae 1 gm/L MUREAV 135,109,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
mouse
lowest published toxic dose: 4,800 mg/kg/12 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
CNREA8 19,413,1959


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 215 mg/kg N/R BEXBAN 61,291,1966
intravenous
dog
lowest published lethal dose: 700 mg/kg N/R VCVGK* -,227,1994
oral
human
lowest published lethal dose: 29 mg/kg N/R 34ZIAG -,519,1969
oral
mouse
lethal dose (50 percent kill): 200 mg/kg N/R JJTOEX 4,105,1991
oral
rat
lethal dose (50 percent kill): 301 mg/kg N/R VCVGK* -,227,1994
oral
rat
lowest published lethal dose: 300 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
RTOPDW 36,198,2002
parenteral
frog
lowest published lethal dose: 270 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes
AEPPAE 166,437,1932
subcutaneous
cat
lowest published lethal dose: 110 mg/kg Behavioral: Convulsions or effect on seizure threshold

Blood: Methemoglobinemia- Carboxhemoglobinemia
AEXPBL 72,241,1913
subcutaneous
cat
lowest published lethal dose: 110 mg/kg N/R VCVGK* -,227,1994
subcutaneous
guinea pig
lowest published lethal dose: 400 mg/kg Behavioral: Excitement

Behavioral: Tetany

Behavioral: Coma
RMSRA6 15,561,1895
subcutaneous
guinea pig
lowest published lethal dose: 400 mg/kg N/R VCVGK* -,227,1994
subcutaneous
mouse
lethal dose (50 percent kill): 213 mg/kg N/R ZGIMAL 2,333,1947
subcutaneous
rat
lowest published lethal dose: 400 mg/kg Behavioral: Excitement

Behavioral: Tetany

Behavioral: Coma
RMSRA6 15,561,1895
subcutaneous
rat
lowest published lethal dose: 400 mg/kg N/R VCVGK* -,227,1994
skin
mouse
lowest published lethal dose: 340 mg/kg N/R VCVGK* -,226,1994
skin
rabbit
lethal dose (50 percent kill): 3,360 mg/kg Skin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AIHAAP 37,596,1976
skin
rabbit
lethal dose (50 percent kill): 3,360 mg/kg N/R VCVGK* -,227,1994
skin
rabbit
lowest published lethal dose: 3,360 mg/kg N/R RTOPDW 36,198,2002


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 3,600 mg/kg/17 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-403,1992
oral
mouse
lowest published toxic dose: 27,300 mg/kg/13 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-403,1992
oral
mouse
lowest published toxic dose: 115,875 mg/kg/103 week- intermittent Skin and Appendages: Tumors

Tumorigenic: Active as anti-cancer agent
NTIS** PB93-126381
oral
rat
lowest published toxic dose: 5,400 mg/kg/17 day- intermittent Endocrine: Changes in thymus weight NTPTR* NTP-TR-403,1992
oral
rat
lowest published toxic dose: 25,750 mg/kg/103 week- intermittent Skin and Appendages: Tumors

Tumorigenic: Active as anti-cancer agent
NTIS** PB93-126381
oral
rat
lowest published toxic dose: 5,915 mg/kg/13 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in adrenal weight
RTOPDW 36,198,2002
oral
rat
lowest published toxic dose: 47,320 mg/kg/13 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in adrenal weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
RTOPDW 36,198,2002
oral
rat
lowest published toxic dose: 150 mg/kg/30 day- intermittent Endocrine: Thyroid weight (goiter)

Endocrine: Evidence of thyroid hypofunction
RTOPDW 36,198,2002
subcutaneous
rat
lowest published toxic dose: 20,700 mg/kg/69 day- intermittent Endocrine: Thyroid weight (goiter) RTOPDW 36,198,2002
skin
rat
lowest published toxic dose: 21,000 mg/kg/4 week- intermittent Endocrine: Thyroid weight (goiter) RTOPDW 36,198,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm;short term exposure limit 20 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 15,155,1977
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 71,1119,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 15,155,1977
International Agency for Research on Cancer (IARC) Cancer Review Human No adequate Data IMEMDT 71,1119,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1119,1999
TOXICOLOGY REVIEW
MUREAV 47,75,1978
TOXICOLOGY REVIEW
JACTDZ 5(3),167,1986
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
EMMUEG 39,69,2002
TOXICOLOGY REVIEW
JEADV* 13,14,1999
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
EMCNA* 25,375,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (45 mg/m3), short term exposure limit 20 ppm (90 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (46 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 20 ppm (91 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (45 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 45 mg/m3 (10 mL/m3), FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 10 ppm (45 mg/m3), short term exposure limit 20 ppm (90 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 10 ppm (45 mg/m3), FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 45 mg/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 10 ppm (45 mg/m3), short term exposure limit 20 ppm (90 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 ppm (45 mg/m3);
short term exposure limit 20 ppm (90 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 45 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 ppm (45 mg/m3), short term exposure limit 20 ppm (90 mg/m3), JAN2002
Occupational Exposure Limit - POLAND MAC(time-weighted average) 45 mg/m3, MAC(short term exposure limit) 90 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 10 ppm (45 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 10 ppm, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 ppm (46 mg/m3);
short term exposure limit 20 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO RESORCINAL-air 10 hour time-weighted average 10 ppm;
short term exposure limit 20 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 67220;
Number of Industries 45;
Total Number of Facilities 4,488;
Number of Occupations 42;
Total Number of Employees Exposed 40,431
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 67220;
Number of Industries 30;
Total Number of Facilities 6,842;
Number of Occupations 43;
Total Number of Employees Exposed 100,792;
Total Number of Female Employees Exposed 56,465


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the production of RESORCINOL-FORMALDEHYDE adhesives, or as an intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis Studies (gavagae);no evidence:mouse,rat NTPTR* NTP-TR-403,1992
NCI Carcinogenesis Studies (gavage);no evidence:mouse,rat
NTP Carcinogenesis studies; test completed (peer review), October 2000


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMCNA*
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. (Pittsburgh, PA) 1947-69.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JEADV* Journal of the European Academy of Dermatology and Venereology : JEADV (Amsterdam ; New York : Elsevier Science Publishers) V.1- 1992-
JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La Suisse Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.1- 1881-
RTOPDW Regulatory Toxicology and Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
ZGIMAL Zeitschrift fuer die Gesamte Innere Medizin und Ihre Grenzgebiete. (Buchexport, Postfach 160, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1946-

Used in the production of RESORCINOL-FORMALDEHYDE adhesives, or as an intermediate

NIOSH PROFILE (HAIRDRESSING and BARBERS), SRC, 6/80

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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