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Propene, 1,3 - dichloro -

RTECS #: UC8310000

CAS #: 542-75-6


UPDATE: May 2009 MW: 110.97 MF: C3H4Cl2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,3 - Dichloro - 2 - propene
  2. 1,3 - Dichloropropene
  3. 1,3 - Dichloropropene (ACGIH)
  4. 1,3 - Dichloropropene, technical grade
  5. 1,3 - Dichloropropene - 1
  6. 1,3 - Dichloropropylene
  7. 3 - Chloroallyl chloride
  8. 3 - Chloropropenyl chloride
  9. D - D 92
  10. DD 95
  1. Dorlone II
  2. NCI - C03985
  3. RCRA waste number U084
  4. Telone
  5. Telone II
  6. Telone II soil fumigant
  7. alpha,gamma - Dichloropropylene
  8. alpha - Chloroallyl chloride
  9. gamma - Chloroallyl chloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 49,100 µg/L EMMUEG 13,60,1989
DNA damage intraperitoneal
mouse
150 mg/kg MUREAV 419,13,1998
mutation in microorganisms Salmonella typhimurium 33 µg/plate (+enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms Salmonella typhimurium 10 µmol/plate (-enzymatic activation step) ENMUDM 2,59,1980
mutation in microorganisms Salmonella typhimurium 0.4 µmol/L/3 day (-enzymatic activation step) MUREAV 572,98,2005
mutation in microorganisms Salmonella typhimurium 50 mg/L/2 hour (-enzymatic activation step) EMMUEG 44,329,2004
mutation in microorganisms Salmonella typhimurium 100 mg/L/2 hour (+enzymatic activation step) EMMUEG 44,329,2004
mutation in mammalian somatic cells mouse lymphocyte 3 mg/L SCIEAS 236,933,1987
other mutation test systems Escherichia coli 1 mmol/L MUREAV 203,81,1988
sister chromatid exchange hamster ovary 900 nmol/L CNJGA8 22,681,1980
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
5,750 ppm ENMUDM 7,325,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 60 ppm/6 hour/5 day/2 year Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
FAATDF 12,418,1989
oral
mouse
lowest published toxic dose: 31,200 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
NTPTR* NTP-TR-269,1985
oral
mouse
lowest published toxic dose: 15,600 mg/kg/104 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Gastrointestinal: Tumors
NTIS** PB85-230449/AS
oral
mouse
lowest published toxic dose: 31,200 mg/kg/104 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB85-230449/AS
oral
mouse
lowest published toxic dose: 15,600 mg/kg/104 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
NTIS** PB85-230449/AS
oral
rat
lowest published toxic dose: 15,600 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
NTPTR* NTP-TR-269,1985
oral
rat
lowest published toxic dose: 15,600 mg/kg/104 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB85-230449/AS
oral
rat
lowest published toxic dose: 7,800 mg/kg/104 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
NTIS** PB85-230449/AS
oral
rat
lowest published toxic dose: 7,800 mg/kg/104 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Gastrointestinal: Tumors
NTIS** PB85-230449/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published lethal concentration: 400 ppm/7 hour N/R AIHAAP 38,217,1977
inhalation
human
lowest published toxic concentration: 1,500 ppm Lung, Thorax, or Respiration: Cough VCVGH* -,474,1990
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 3.88 gm/m3/4 hour N/R FEREAC 65,1869,2000
inhalation
mouse
lethal concentration (50 percent kill): 3,220 mg/m3/2 hour N/R VCVGH* -,473,1990
inhalation
rat
lowest published lethal concentration: 1,000 ppm/2 hour Eye: Lacrimation AIHAAP 38,217,1977
intraperitoneal
mouse
lowest published toxic dose: 100 mg/kg Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
CRTOEC 13,1096,2000
intraperitoneal
mouse
lowest published lethal dose: 700 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases TOXID9 1,90,2001
intraperitoneal
mouse
lowest published lethal dose: 700 mg/kg N/R TOXID9 1,90,2001
intraperitoneal
rat
lethal dose (50 percent kill): 175 mg/kg N/R TOXID9 5,2,1985
oral
mammal (species unspecified)
lethal dose (50 percent kill): 224 mg/kg N/R FEREAC 65,1869,2000
oral
mouse
lethal dose (50 percent kill): 640 mg/kg N/R ENTOX* -,11,2005
oral
rat
lethal dose (50 percent kill): 470 mg/kg N/R ENTOX* -,11,2005
skin
rat
lethal dose (50 percent kill): 775 mg/kg N/R FMCHA2 -,C103,1991
skin
rabbit
lethal dose (50 percent kill): 333 mg/kg N/R FEREAC 65,1869,2000


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 90 ppm/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 11,207,1988
inhalation
rat
lowest published toxic concentration: 90 ppm/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 11,207,1988
oral
dog
lowest published toxic dose: 3,731 mg/kg/13 week- continuous Blood: Microcytosis with or without anemia

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
RTOPDW 30,233,1999
oral
dog
lowest published toxic dose: 5,460 mg/kg/1 year- continuous Blood: Microcytosis with or without anemia

Blood: Changes in bone marrow not included in above

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
RTOPDW 30,233,1999
oral
mouse
lowest published toxic dose: 1,365 mg/kg/13 week- continuous Cardiac: Changes in heart weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 32,224,1996
oral
rat
lowest published toxic dose: 455 mg/kg/26 week- intermittent Gastrointestinal: Changes in structure or function of exocrine pancreas

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
GISAAA 39(1),94,1974
oral
rat
lowest published toxic dose: 1,365 mg/kg/13 week- continuous Gastrointestinal: Alteration in gastric secretion

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 32,224,1996
unreported route
rat
lowest published toxic dose: 750 mg/kg/30 day- intermittent Liver: Other changes

Liver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TOXID9 78,115,2004
unreported route
rat
lowest published toxic dose: 1,500 mg/kg/60 day- intermittent Liver: Other changes

Liver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TOXID9 78,115,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 41,113,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,933,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 41,113,1986
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,933,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,933,1999
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
ENTOX* -,11,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
BCLPT* 96,131,2005
TOXICOLOGY REVIEW
FEREAC 73,8212,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
FEREAC 73,8212,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
HUTOX* -,561,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,151,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (4.5 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (4.6 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (5 mg/m3), OCT 2002
Occupational Exposure Limit - KOREA time-weighted average 1 ppm (5 mg/m3), skin, 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1 ppm (4.5 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.11 ppm (0.5 mg/m3), Skin, Carcinogen, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,3-DICHLOROPROPENE-air Carcinogen;
8 hour time-weighted average 1 ppm (Sk)
NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3912;
Number of Industries 3;
Total Number of Facilities 48;
Number of Occupations 14;
Total Number of Employees Exposed 2,162;
Total Number of Female Employees Exposed 33


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110765/AS)
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a soil fumigant prior to planting crops such as cotton, sugar beet, potatoes
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
BCLPT* Basic & clinical pharmacology & toxicology (Copenhagen, Denmark : Nordic Pharmacological Society Oxford, UK : Distributed by Blackwell Munksgaard) V.94- 2004-
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 1959-
CRTOEC Chemical Research in Toxicology. (American Chemical Soc., Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC 20037) V.1- 1988-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HUTOX*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RTOPDW Regulatory Toxicology and Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as a soil fumigant prior to planting crops such as cotton, sugar beet, potatoes

NIOSH PROFILE (FUMIGANTS), SRC, 10/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data

ALT CAS #: 8022-76-2
Click Here for Additional Information about RTECS

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