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2 - Propanone, 1,1,1,3,3,3 - hexafluoro -

RTECS #: UC2450000

CAS #: 684-16-2


UPDATE: May 2009 MW: 166.03 MF: C3F6O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 6FK
  2. Acetone, hexafluoro -
  3. Hexafluoroacetone
  1. Hexafluoroacetone (ACGIH)
  2. NCI - C56440


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 12 ppm/6 hour (30 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TXCYAC 67,249,1991
skin
rat
lowest published toxic dose: 100 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) FAATDF 2,73,1982
skin
rat
lowest published toxic dose: 55 mg/kg (6-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TXAPA9 41,195,1977


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published lethal concentration: 30,600 mg/m3/45 minute Vascular: BP lowering not characterized in autonomic section VCVGK* -,437,1994
inhalation
rat
lethal concentration (50 percent kill): 275 ppm/3 hour N/R TXAPA9 6,341,1964
inhalation
rat
lethal concentration (50 percent kill): 5,520 mg/m3/30 minute Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes
VCVGK* -,437,1994
inhalation
rat
lethal concentration (50 percent kill): 1,690 mg/m3/3 hour Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes
VCVGK* -,437,1994
oral
rat
lethal dose (50 percent kill): 191 mg/kg N/R TXAPA9 6,341,1964
skin
rat
lowest published toxic dose: 13 mg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct VCVGK* -,437,1994
skin
rat
lowest published toxic dose: 39 mg/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) VCVGK* -,437,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rat
lowest published toxic dose: 117 mg/kg/3 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct VCVGK* -,437,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm (skin) DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 ppm (0.7 mg/m3) DTLWS* 3,20,1973
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.68 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.69 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.7 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.1 ppm (0.7 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm (0.7 mg/m3), FEB2006
Occupational Exposure Limit - KOREA time-weighted average 0.1 ppm (0.7 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.1 ppm (0.7 mg/m3);
short term exposure limit 0.3 ppm (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.05 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 ppm (0.68 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 ppm (0.7 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.7 mg/m3), Skin, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 ppm (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HEXAFLUOROACETONE-air 10 hour time-weighted average 0.1 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83899;
Number of Industries 1;
Total Number of Facilities 14;
Number of Occupations 1;
Total Number of Employees Exposed 141


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a chemical intermediate

NIOSH PROFILE (HEXAFLUOROACETONE), SRC, 10/77

RTECS Compound Description:
   Reproductive Effector

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