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Propane, 2,2' - oxybis -

RTECS #: TZ5425000

CAS #: 108-20-3


UPDATE: May 2009 MW: 102.20 MF: C6H14O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - Isopropoxypropane
  2. Diisopropyl oxide
  3. Ether isopropylique (French)
  4. Ether, isopropyl
  1. Isopropyl ether
  2. Isopropyl ether (ACGIH:OSHA)
  3. Izopropylowy eter (Polish)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
363 mg open irritation test mild UCDS** 4/10/1968


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 3,095 ppm/6 hour (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JTEHD6 49,29,1996
inhalation
rat
lowest published toxic concentration: 10,000 mg/m3 (10 day prior to copulation) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) VCVGK* -,266,1994


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published lethal concentration: 6 pph Behavioral: General anesthetic

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,266,1994
inhalation
guinea pig
lowest published toxic concentration: 3 pph Behavioral: General anesthetic VCVGK* -,266,1994
inhalation
human
lowest published toxic concentration: 1,250 mg/m3/3 minute Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVGK* -,267,1994
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 130 gm/m3 N/R GTPZAB 32(10),25,1988
inhalation
monkey
lowest published lethal concentration: 6 pph Behavioral: General anesthetic

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,266,1994
inhalation
monkey
lowest published toxic concentration: 3 pph Behavioral: General anesthetic VCVGK* -,266,1994
inhalation
mouse
lethal concentration (50 percent kill): 131 gm/m3 Behavioral: General anesthetic

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity
GTPZAB 19(10),55,1975
inhalation
mouse
lethal concentration (50 percent kill): 130,800 mg/m3 Behavioral: General anesthetic

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,266,1994
inhalation
rat
lethal concentration (50 percent kill): 162 gm/m3 Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity
GTPZAB 19(10),55,1975
inhalation
rat
lethal concentration (50 percent kill): 161,700 mg/m3 Behavioral: General anesthetic

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,266,1994
inhalation
rat
lowest published toxic concentration: 500 ppm/6 hour Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 90,374,2006
inhalation
rabbit
lethal concentration (50 percent kill): 121 gm/m3 Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity
GTPZAB 19(10),55,1975
inhalation
rabbit
lethal concentration (50 percent kill): 120,600 mg/m3 Behavioral: General anesthetic

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,266,1994
inhalation
rabbit
lowest published lethal concentration: 6 pph Behavioral: General anesthetic

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,266,1994
inhalation
rabbit
lowest published toxic concentration: 3 pph Behavioral: General anesthetic VCVGK* -,266,1994
intraperitoneal
mouse
lethal dose (50 percent kill): 812 mg/kg N/R SCCUR* -,5,1961
oral
mammal (species unspecified)
lethal dose (50 percent kill): 6 gm/kg N/R GTPZAB 32(10),25,1988
oral
mouse
lethal dose (50 percent kill): 3,600 mg/kg N/R VCVGK* -,266,1994
oral
rat
lethal dose (50 percent kill): 5,880 mg/kg N/R VCVGK* -,266,1994
oral
rabbit
lowest published lethal dose: 6 gm/kg Behavioral: Altered sleep time (including change in righting reflex) JIHTAB 21(3),72,1939
skin
rabbit
lethal dose (50 percent kill): 20 mL/kg N/R UCDS** 4/10/1968
unreported route
mouse
lethal dose (50 percent kill): 3,600 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity
GTPZAB 19(10),55,1975
unreported route
rat
lethal dose (50 percent kill): 5,880 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity
GTPZAB 19(10),55,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 2,090 mg/m3/5 hour/22 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Blood: Other changes
GTPZAB 19(10),55,1975
inhalation
rat
lowest published toxic concentration: 3,300 ppm/6 hour/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
JTEHD6 49,29,1996
inhalation
rat
lowest published toxic concentration: 7,500 mg/m3/30 day- intermittent Behavioral: Irritability

Brain and Coverings: Increased intracranial pressure
VCVGK* -,266,1994
inhalation
rat
lowest published toxic concentration: 10,000 mg/m3/4 hour/10 day- intermittent Endocrine: Effect on menstrual cycle

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)
VCVGK* -,266,1994
inhalation
rat
lowest published toxic concentration: 2,090 mg/m3/5 hour/152 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Liver function tests impaired
VCVGK* -,267,1994
inhalation
rat
lowest published toxic concentration: 500 ppm/5 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 90,374,2006
inhalation
rabbit
lowest published toxic concentration: 2,090 mg/m3/5 hour/22 week- intermittent Behavioral: Muscle contraction or spasticity

Liver: Liver function tests impaired
GTPZAB 19(10),55,1975
inhalation
rabbit
lowest published toxic concentration: 2,090 mg/m3/5 hour/152 day- intermittent Cardiac: Other changes

Lung, Thorax, or Respiration: Emphysema

Blood: Changes in spleen
VCVGK* -,267,1994
inhalation
rabbit
lowest published toxic concentration: 507 mg/m3/5 hour/152 day- intermittent Liver: Multiple effects VCVGK* -,267,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 250 ppm;short term exposure limit 310 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
ENTOX* -,387,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 250 ppm (1050 mg/m3) DTLVS* 3,142,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 500 ppm (2100 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 500 ppm (2100 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 500 ppm (2100 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 500 ppm (2100 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 250 ppm (1040 mg/m3), short term exposure limit 310 ppm (1300 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 250 ppm (1055 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 310 ppm (1319 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 250 ppm (1050 mg/m3), OCT 2002
Occupational Exposure Limit - FRANCE VME 250 ppm (1050 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 850 mg/m3 (200 mL/m3), 2005
Occupational Exposure Limit - KOREA time-weighted average 250 ppm (1025 mg/m3), short term exposure limit 310 ppm (1320 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 250 ppm (1050 mg/m3);
short term exposure limit 310 ppm (1320 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1050 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 250 ppm (1040 mg/m3);
short term exposure limit 310 ppm (1300 mg/m3),JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 125 ppm (525 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1000 mg/m3, MAC(short term exposure limit) 1300 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 100 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 200 ppm (850 mg/m3),KZG- week 400 ppm (1700 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 500 ppm (2100 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 250 ppm (1060 mg/m3);
short term exposure limit 310 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 250 ppm;
short term exposure limit 310 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 250 ppm;
short term exposure limit 310 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ISOPROPYL ETHER-air 10 hour time-weighted average 500 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 25905;
Number of Industries 11;
Total Number of Facilities 952;
Number of Occupations 11;
Total Number of Employees Exposed 12,024
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 25905;
Number of Industries 5;
Total Number of Facilities 130;
Number of Occupations 11;
Total Number of Employees Exposed 3,253;
Total Number of Female Employees Exposed 1,126


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent or as an additive for gasolines
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Isopropyl ether, 1618


REFERENCES:

CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a solvent or as an additive for gasolines

RTECS Compound Description:
   Reproductive Effector
   Human Data
   Primary Irritant

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