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Propane, 1,2 - epoxy - 3 - phenoxy -

RTECS #: TZ3675000

CAS #: 122-60-1


UPDATE: May 2009 MW: 150.19 MF: C9H10O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. (Phenoxymethyl) oxirane
  2. 1,2 - Epoxy - 3 - phenoxypropane
  3. 2,3 - Epoxypropylphenyl ether
  4. 3 - Phenoxy - 1,2 - epoxypropane
  5. Ageflex PGE
  6. Benzene, (2,3 - epoxypropoxy) -
  7. Ether, 2,3 - epoxypropyl phenyl
  8. Ether, phenylglycidyl
  9. Fenyl - glycidylether (Czech)
  10. Glycidyl phenyl ether
  11. Heloxy WC - 63
  1. Oxirane, (phenoxymethyl) -
  2. PGE (OSHA)
  3. Phenol glycidyl ether
  4. Phenol - glycidaether (German)
  5. Phenoxypropene oxide
  6. Phenoxypropylene oxide
  7. Phenyl 2,3 - epoxypropyl ether
  8. Phenyl glycidyl ether
  9. Phenyl glycidyl ether (ACGIH:OSHA)
  10. Phenylglycydyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
111 mg mild AMIHAB 14,250,1956
eye
rabbit
250 µg/24 hour severe 85JCAE -,776,1986
skin
rabbit
10 mg/24 hour open irritation test severe AMIHBC 10,61,1954
skin
rabbit
20 mg/24 hour moderate 85JCAE -,776,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage Escherichia coli 1 µmol/L ARTODN 46,277,1980
host-mediated assay mouse
Salmonella typhimurium
2,500 mg/kg MUREAV 67,9,1979
mutation in microorganisms Escherichia coli 20 µmol/L (-enzymatic activation step) ARTODN 46,277,1980
mutation in microorganisms Klebsiella pneumoniae 100 µmol/L (-enzymatic activation step) MUREAV 89,269,1981
mutation in microorganisms Salmonella typhimurium 33 µg/plate (+enzymatic activation step) MUREAV 172,105,1986
mutation in microorganisms Salmonella typhimurium 500 µg/plate (-enzymatic activation step) MUREAV 67,9,1979
morphological transform hamster embryo 6,250 µg/L MUREAV 67,9,1979
other mutation test systems Escherichia coli 300 µmol/L MUREAV 231,205,1990
sister chromatid exchange hamster lung 400 µmol/L MUREAV 249,55,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 11 ppm/6 hour (19 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) TXAPA9 64,204,1982


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 12 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
AJPAA4 111,140,1983
inhalation
rat
lowest published toxic concentration: 1,092 mg/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors
TOXID9 72,27,2003
inhalation
rat
lowest published toxic concentration: 728 mg/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors
TOXID9 72,27,2003


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): >100 ppm/4 hour Lung, Thorax, or Respiration: Acute pulmonary edema AMIHAB 14,250,1956
inhalation
rat
lethal concentration (50 percent kill): >100 ppm/8 hour Lung, Thorax, or Respiration: Acute pulmonary edema AMIHAB 14,250,1956
oral
mouse
lethal dose (50 percent kill): 1,400 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
AMIHAB 14,250,1956
oral
rat
lethal dose (50 percent kill): 3,850 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia
AMIHAB 14,250,1956
subcutaneous
mouse
lethal dose (50 percent kill): 760 mg/kg Autonomic Nervous System: Smooth muscle relaxant (mechanism undefined, spasmolytic) ARZNAD 15,1355,1965
skin
human
lowest published toxic concentration: 0.25 pph Skin: After topical application: Dermatitis, allergic AJCDE* 13,108,2002
skin
rabbit
lethal dose (50 percent kill): 1,500 µL/kg N/R AMIHBC 10,61,1954


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 5 ppm/6 hour/90 day- intermittent Skin and Appendages: Other: Hair JTEHD6 3,859,1977
inhalation
rat
lowest published toxic concentration: 728 mg/kg/2 year- intermittent Olfaction: Other olfaction effects TOXID9 72,27,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm (skin, sen) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 47,237,1989
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,1525,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1525,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,1525,1999
TOXICOLOGY REVIEW
AJOGAH 113,130,1972
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 ppm (62 mg/m3) DTLVS* 3,206,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 10 ppm (60 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 10 ppm (60 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 10 ppm (60 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 10 ppm (60 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (6.1 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.6 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.6 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND short term exposure limit 10 ppm (60 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 1 ppm (6 mg/m3), continuous2 Carcinogen, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 1 ppm (6 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 ppm (60 mg/m3) (skin), 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1 ppm (6.1 mg/m3), skin, sen, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 10 ppm (62 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.6 mg/m3, MAC(short term exposure limit) 3 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 10 ppm (60 mg/m3);
short term exposure limit 15 ppm (90 mg/m3), Sen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (6 mg/m3), Skin, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 10 ppm (60 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHENYL GLYCIDYL ETHER-air Carcinogen ceiling concentration 1 ppm/15 minute NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 57280;
Number of Industries 13;
Total Number of Facilities 434;
Number of Occupations 12;
Total Number of Employees Exposed 8,533
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 57280;
Number of Industries 15;
Total Number of Facilities 355;
Number of Occupations 18;
Total Number of Employees Exposed 10,551;
Total Number of Female Employees Exposed 4,108


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: SHE-focus assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used to increase storage time and stability of halogenated compounds
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 29, 1978
NIOSH Analytical Method, 1994: Phenyl glycidyl ether, 1619


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AJCDE* American Journal of Contact Dermatitis: Official Journal of the American Contact Dermatitis Society (Philadelphia, PA : W.B. Saunders, Harcourt Brace Jovanovich) V.1-14 1990-2003.
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used to increase storage time and stability of halogenated compounds

NIOSH PROFILE (ETHERS, GLYCIDYL), SRC, 10/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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