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Propane, 1,2 - epoxy -

RTECS #: TZ2975000

CAS #: 75-56-9


UPDATE: May 2009 MW: 58.09 MF: C3H6O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1,2 - Epoxypropane
  2. 1,2 - Epoxypropane (ACGIH:OSHA)
  3. 1,2 - Propylene oxide
  4. 2,3 - Epoxypropane
  5. AD 6 (suspending agent)
  6. Epoxypropane
  7. Ethylene oxide, methyl -
  8. Methyl ethylene oxide
  9. Methyl oxirane
  1. Methyloxacyclopropane
  2. NCI - C50099
  3. Oxirane, methyl -
  4. Oxyde de propylene (French)
  5. Propane, epoxy -
  6. Propene oxide
  7. Propylene epoxide
  8. Propylene oxide
  9. Propylene oxide (DOT:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
20 mg severe AJOPAA 29,1363,1946
eye
rabbit
20 mg/24 hour moderate 85JCAE -,768,1986
skin
rabbit
415 mg open irritation test moderate UCDS** 12/13/1963
skin
rabbit
50 mg/6 minute severe AMIHAB 13,228,1956


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 160 mg/L SCIEAS 236,933,1987
cytogenetic analysis human lymphocyte 1,850 g/L MUREAV 67,101,1979
cytogenetic analysis intraperitoneal
mouse
349 mg/kg MUREAV 288,223,1993
cytogenetic analysis rat liver 25 g/L MUREAV 153,57,1985
dominant lethal test inhalation
rat
300 ppm/5 day- intermittent MUREAV 117,337,1983
DNA adduct inhalation
Drosophila melanogaster
2 ppm/24 hour MUREAV 529,95,2003
DNA adduct mammal (species unspecified) lymphocyte 100 mmol/tube CBINA8 67,275,1988
DNA adduct inhalation
rat
600 mg/kg/4 week- intermittent CRNGDP 21,2011,2000
DNA adduct inhalation
rat
5 ppm/3 day- intermittent CRNGDP 24,1233,2003
DNA damage Escherichia coli 1 mol/L ARTODN 46,277,1980
DNA damage mammal (species unspecified) lymphocyte 75 mmol/L CBINA8 9,97,1974
DNA damage intraperitoneal
mouse
200 mg/kg MUREAV 467,83,2000
DNA damage other fish testis 5 gm ABBIA4 97,80,1962
DNA damage other microorganisms 1 mmol/L MUREAV 368,235,1996
DNA damage rat liver 30 mol/L SinJF# 26OCT1982
DNA damage inhalation
rat
25 ppm/3 day- intermittent TXAPA9 191,245,2003
DNA damage salmon sperm 5 mL ABBIA4 97,80,1962
mutation in microorganisms Escherichia coli 700 g/plate (+/-enzymatic activation step) MUREAV 67,101,1979
mutation in microorganisms Klebsiella pneumoniae 500 mol/L (-enzymatic activation step) MUREAV 89,269,1981
mutation in microorganisms Neurospora crassa 500 mmol/L (-enzymatic activation step) GENTAE 40,890,1955
mutation in microorganisms other microorganisms 25 mmol/L (-enzymatic activation step) MUREAV 73,1,1980
mutation in microorganisms other microorganisms 5 mmol/plate (-enzymatic activation step) EMMUEG 23,274,1994
mutation in microorganisms Salmonella typhimurium 350 g/plate (+enzymatic activation step) ABCHA6 47,2461,1983
mutation in microorganisms Salmonella typhimurium 700 g/plate (-enzymatic activation step) MUREAV 67,101,1979
mutation in microorganisms Salmonella typhimurium 100 mg/L/2 hour (-enzymatic activation step) EMMUEG 44,329,2004
mutation in microorganisms Salmonella typhimurium 1,000 mg/L/2 hour (+enzymatic activation step) EMMUEG 44,329,2004
mutation in microorganisms Salmonella typhimurium 50 g/plate/72 hour (-enzymatic activation step) TOXID9 228,66,2006
mutation in microorganisms Saccharomyes cerevisiae 50 mmol/L (-enzymatic activation step) MUREAV 250,229,1991
mutation in microorganisms Schizosaccharomyces pombe 183 mmol/L (-enzymatic activation step) ADWMAX -,193,1962
micronucleus test intraperitoneal
mouse
600 mg/kg/24 hour MUREAV 67,101,1979
gene conversion and mitotic recombination Saccharomyes cerevisiae 25 mmol/L MUREAV 250,229,1991
mutation in mammalian somatic cells mouse lymphocyte 400 g/L SCIEAS 236,933,1987
other mutation test systems Salmonella typhimurium 1 pph ENMUDM 9,171,1987
sister chromatid exchange hamster ovary 5 mg/L SCIEAS 236,933,1987
sister chromatid exchange hamster lung 2,500 mol/L MUREAV 249,55,1991
sister chromatid exchange human lymphocyte 25,000 ppm ENMUDM 7(Suppl 3),48,1985
sister chromatid exchange intraperitoneal
mouse
232 mg/kg MUREAV 288,223,1993
sister chromatid exchange Saccharomyes cerevisiae 100 mmol/L MUREAV 250,229,1991
sex chromosome loss and nondisjunction inhalation
Drosophila melanogaster
645 ppm/24 hour- continuous MUREAV 117,337,1983
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
1 ppb EMMUEG 23,208,1994
sex chromosome loss and nondisjunction parenteral
Drosophila melanogaster
10 ppb EMMUEG 23,208,1994
specific locus test inhalation
Drosophila melanogaster
1,500 ppm MUREAV 405,259,1998
specific locus test inhalation
Drosophila melanogaster
3.9 ppm/24 hour MUREAV 529,95,2003
specific locus test mouse lymphocyte 160 ppm/48 hour- continuous EMMUEG 17,122,1991
heritable translocation test parenteral
Drosophila melanogaster
10 ppb EMMUEG 23,208,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
monkey
lowest published toxic concentration: 100 ppm/7 hour (2 year male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TOXID9 3,60,1983
inhalation
rat
lowest published toxic concentration: 500 ppm/7 hour (7-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** PB83-258038
inhalation
rat
lowest published toxic concentration: 500 ppm/7 hour (1-16 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) NTIS** PB83-258038
inhalation
rat
lowest published toxic concentration: 500 ppm/7 hour (15 day prior to copulation/1-16 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on fertility: Other measures of fertility
SWEHDO 9,94,1983
intraperitoneal
rat
lowest published toxic dose: 47 mg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NEZAAQ 49,168,1994
intraperitoneal
rat
lowest published toxic dose: 1,860 mg/kg (6 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
NEZAAQ 49,168,1994


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 400 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
NTPTR* NTP-TR-267,1985
inhalation
mouse
lowest published toxic concentration: 400 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
JJIND8 77,573,1986
inhalation
mouse
lowest published toxic concentration: 24,720 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
NTIS** PB85-179653/AS
inhalation
mouse
lowest published toxic concentration: 24,720 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Olfaction: Tumors
NTIS** PB85-179653/AS
inhalation
rat
lowest published toxic concentration: 100 ppm/7 hour/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Tumors
TXAPA9 76,69,1984
inhalation
rat
toxic concentration (other than lowest) : 400 ppm/6 hour/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors
JJIND8 77,573,1986
inhalation
rat
toxic concentration (other than lowest) : 300 ppm/6 hour/2.3 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
FCTOD7 26,159,1988
inhalation
rat
lowest published toxic concentration: 12,360 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Olfaction: Tumors
NTIS** PB85-179653/AS
inhalation
rat
lowest published toxic concentration: 10,300 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Olfaction: Tumors

Endocrine: Thyroid tumors
NTIS** PB85-179653/AS
oral
rat
lowest published toxic dose: 10,798 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
BJCAAI 46,924,1982
oral
rat
toxic dose : 2,714 mg/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
BJCAAI 46,924,1982
subcutaneous
mouse
lowest published toxic dose: 272 mg/kg/95 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application
ZHPMAT 174,383,1981
subcutaneous
mouse
toxic dose : 3,640 mg/kg/91 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application
BJCAAI 39,588,1979
subcutaneous
mouse
toxic dose : 868 mg/kg/95 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application
ZHPMAT 174,383,1981
subcutaneous
mouse
toxic dose : 2,912 mg/kg/95 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application
ZHPMAT 174,383,1981
subcutaneous
mouse
toxic dose : 6,616 mg/kg/95 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application
ZHPMAT 174,383,1981
subcutaneous
rat
lowest published toxic dose: 1,500 mg/kg/46 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Facilitates action of known carcinogens
ANYAA9 68,750,1958


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published lethal concentration: 2,005 ppm/4 hour Olfaction: Other olfaction effects

Eye: Lacrimation

Gastrointestinal: Nausea or vomiting
AMIHAB 13,237,1956
inhalation
guinea pig
lowest published lethal concentration: 4,000 ppm/4 hour Eye: Iritis

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea
AMIHAB 13,228,1956
inhalation
man
lowest published toxic concentration: 1,400 gm/m3/10 minute Behavioral: Somnolence (general depressed activity)

Behavioral: Headache

Gastrointestinal: Nausea or vomiting
GTPZAB 15(2),48,1971
inhalation
mouse
lethal concentration (50 percent kill): 1,740 ppm/4 hour Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
AMIHAB 13,237,1956
inhalation
rat
lethal concentration (50 percent kill): 4,000 ppm/4 hour Olfaction: Other olfaction effects

Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea
AMIHAB 13,237,1956
intraperitoneal
mouse
lethal dose (50 percent kill): 175 mg/kg N/R 85GMAT -,103,1982
intraperitoneal
rat
lethal dose (50 percent kill): 150 mg/kg N/R 85GMAT -,103,1982
oral
guinea pig
lethal dose (50 percent kill): 660 mg/kg Behavioral: Somnolence (general depressed activity)

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
GISAAA 46(7),76,1981
oral
mammal (species unspecified)
lethal dose (50 percent kill): 440 mg/kg N/R GISAAA 39(4),86,1974
oral
mouse
lethal dose (50 percent kill): 440 mg/kg Behavioral: Excitement

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation
GTPZAB 14(11),55,1970
oral
rat
lethal dose (50 percent kill): 380 mg/kg Behavioral: Excitement

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation
GTPZAB 14(11),55,1970
skin
rabbit
lethal dose (50 percent kill): 1,500 L/kg N/R AIHAAP 30,470,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 457 ppm/7 hour/22 week- intermittent Eye: Other eye effects

Lung, Thorax, or Respiration: Changes in lung weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AMIHAB 13,228,1956
inhalation
mouse
lowest published toxic concentration: 487 ppm/6 hour/2 week- intermittent Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
NTPTR* NTP-TR-267,1985
inhalation
mouse
lowest published toxic concentration: 125 ppm/6 hour/13 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-267,1985
inhalation
mouse
lowest published toxic dose: 200 ppm/6 hour/4 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes
TOXID9 -,109,2008
inhalation
rat
lowest published toxic concentration: 457 ppm/7 hour/28 week- intermittent Eye: Other eye effects

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHAB 13,228,1956
inhalation
rat
lowest published toxic concentration: 1,433 ppm/6 hour/12 day- intermittent Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-267,1985
inhalation
rat
lowest published toxic concentration: 25 mg/m3/4 hour/26 week- intermittent Brain and Coverings: Changes in surface EEG

Brain and Coverings: Other degenerative changes

Vascular: BP lowering not characterized in autonomic section
GTPZAB 14(11),55,1970
inhalation
rat
lowest published toxic concentration: 529 ppm/6 hour/4 week- intermittent Olfaction: Other olfaction effects FAATDF 27,25,1995
inhalation
rat
lowest published toxic concentration: 997 ppm/6 hour/2 week- intermittent Cardiac: Changes in heart weight

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* OTS0535203
inhalation
rat
lowest published toxic concentration: 50 ppm/6 hour/3 day- intermittent Biochemical: Metabolism (intermediary): Other NSAPCC 375(Suppl 1),88,2007
inhalation
rat
lowest published toxic concentration: 100 ppm/6 hour/3 day- intermittent Olfaction: Other olfaction effects

Biochemical: Metabolism (intermediary): Other
NSAPCC 375(Suppl 1),88,2007
inhalation
rat
lowest published toxic dose: 400 ppm/6 hour/4 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes
TOXID9 -,109,2008
oral
rat
lowest published toxic dose: 1,170 mg/kg/45 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Blood: Other changes
GISAAA 46(7),76,1981


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm (sen) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 36,227,1985
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 60,181,1994
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 36,227,1985
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 60,181,1994
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 60,181,1994
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
TOLED5 140-141,53,2003
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 567,227,2004
TOXICOLOGY REVIEW
MUREAV 567,151,2004
TOXICOLOGY REVIEW
MUREAV 580,91,2005
TOXICOLOGY REVIEW
EMMUEG 39,69,2002
TOXICOLOGY REVIEW
MUTAEX 15,431,2000
TOXICOLOGY REVIEW
MUREAV 627,10,2007
TOXICOLOGY REVIEW
BCLPT* 96,131,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
HETOEA 25,413,2006
TOXICOLOGY REVIEW
FEREAC 73,31788,2008
TOXICOLOGY REVIEW
FEREAC 72,49646,2007
TOXICOLOGY REVIEW
FEREAC 73,31788,2008
TOXICOLOGY REVIEW
FEREAC 72,49646,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,204,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (240 mg/m3) DTLVS* 3,219,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (240 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (240 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (240 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (240 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 20 ppm (48 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit - AUSTRIA TRK 6 mg/m3 (2.5 mL/m3), JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (5 mg/m3), Carcinogen, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (12 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 5 ppm (12 mg/m3), Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 20 ppm (50 mg/m3), continuous2 Carcinogen, FEB2006
Occupational Exposure Limit - HUNGARY ceiling concentration 5 mg/m3, Skin, Carcinogen, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 20 ppm (50 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 20 ppm (50 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 6 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 ppm (12 mg/m3), JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (240 mg/m3), JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 2 ppm (5 mg/m3);
short term exposure limit 10 ppm (25 mg/m3), Carcinogen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 2.5 ppm (6 mg/m3), Skin, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 100 ppm (240 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (12 mg/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPYLENE OXIDE-air Carcinogen lowest feasible concentrtion NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 63550;
Number of Industries 78;
Total Number of Facilities 9,032;
Number of Occupations 60;
Total Number of Employees Exposed 75,135
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 63550;
Number of Industries 57;
Total Number of Facilities 5,786;
Number of Occupations 67;
Total Number of Employees Exposed 421,140;
Total Number of Female Employees Exposed 317,309


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Cell transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Positive: N crassa-reversion; D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: S pombe-reversion
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as an intermediate in the production of polyether polyols and as a fumigant
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 51, JULY 1989
NIOSH Analytical Method, 1994: Propylene oxide, 1612
NCI Carcinogenesis Studies (inhal);clear evidence:mouse
NTP Carcinogenesis Studies (inhalation);some evidence:rat NTPTR* NTP-TR-267,1985
NCI Carcinogenesis Studies (inhal);equivocal evidence:rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
OSHA ANALYTICAL METHOD #88


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951-
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
ADWMAX Abhandlungen der Deutschen Akademie der Wissenschaften zu Berlin, Klasse fuer Medizin. (Berlin, Ger. Dem. Rep.) 1950-68. Discontinued.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BCLPT* Basic & clinical pharmacology & toxicology (Copenhagen, Denmark : Nordic Pharmacological Society Oxford, UK : Distributed by Blackwell Munksgaard) V.94- 2004-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GENTAE Genetics. (Genetics Business Office, POB 64025, Baltimore, MD 21264) V.1- 1916-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
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Used as an intermediate in the production of polyether polyols and as a fumigant

Top 50 chemical production: 2.70 billions lbs in 1992, 2.50 billions in 1991

NIOSH PROFILE (EPOXY COMPOUNDS), SRC, 2/82

NIOSH PROFILE (ORGANIC OXIDES OR EPOXY COMPOUNDS), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Hormone
   Primary Irritant

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