1,2-Propanediol, dinitrate

RTECS #

TY6300000

CAS #

6423-43-4
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

166.11

Molecular Formula

C₃H₆N₂O₆

Synonyms

1,2-Propylene glycol dinitrate
PGDN
Propylene dinitrate
Propylene glycol 1,2-dinitrate
Propylene glycol dinitrate
Propylene glycol dinitrate (ACGIH)

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	100 mg	mild	TXAPA9 22,128,1972

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/human	lowest published toxic concentration: 200 ppb/6H	Behavioral: Headache	TXAPA9 30,377,1974
inhalation/human	lowest published toxic concentration: 1500 ppb/5M	Eye: Conjunctiva irritation	TXAPA9 30,377,1974
intraperitoneal/guinea pig	lethal dose (50 percent kill): 402 mg/kg	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	AIHAAP 34,526,1973
intraperitoneal/mouse	lethal dose (50 percent kill): 1047 mg/kg	Lung, Thorax, or Respiration: Respiratory depression Blood: Methemoglobinemia- Carboxhemoglobinemia Vascular: BP lowering not characterized in autonomic section	AIHAAP 34,526,1973
intraperitoneal/rat	lethal dose (50 percent kill): 479 mg/kg	Lung, Thorax, or Respiration: Respiratory depression Blood: Methemoglobinemia- Carboxhemoglobinemia Vascular: BP lowering not characterized in autonomic section	AIHAAP 34,526,1973
intravenous/monkey	lowest published lethal dose: 410 mg/kg	Eye: Ptosis Behavioral: Ataxia Gastrointestinal: Nausea or vomiting	TXAPA9 22,128,1972
oral/mouse	lethal dose (50 percent kill): 1525 mg/kg	Behavioral: Convulsions or effect on seizure threshold Cardiac: EKG changes not diagnostic of above Blood: Methemoglobinemia- Carboxhemoglobinemia	STGNBT -,94,1999
oral/rat	lethal dose (50 percent kill): 250 mg/kg	Lung, Thorax, or Respiration: Respiratory depression Blood: Methemoglobinemia- Carboxhemoglobinemia Vascular: BP lowering not characterized in autonomic section	AIHAAP 34,526,1973
subcutaneous/cat	lowest published lethal dose: 200 mg/kg	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Other changes Blood: Methemoglobinemia- Carboxhemoglobinemia	TXAPA9 15,175,1969
subcutaneous/mouse	lethal dose (50 percent kill): 1208 mg/kg	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Other changes Blood: Methemoglobinemia- Carboxhemoglobinemia	TXAPA9 15,175,1969
subcutaneous/rat	lethal dose (50 percent kill): 463 mg/kg	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Other changes Blood: Methemoglobinemia- Carboxhemoglobinemia	TXAPA9 15,175,1969

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/Dog	lowest published toxic concentration: 236 mg/m³/24H/90D- continuous	Blood: Pigmented or nucleated red blood cells Liver: Other changes Kidney, Ureter, and Bladder: Other changes	TXAPA9 22,128,1972
inhalation/guinea pig	lowest published toxic concentration: 236 mg/m³/24H/90D- continuous	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	TXAPA9 22,128,1972
inhalation/monkey	lowest published toxic concentration: 236 mg/m³/24H/90D- continuous	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TXAPA9 22,128,1972
inhalation/rat	lowest published toxic concentration: 236 mg/m³/24H/90D- continuous	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	TXAPA9 22,128,1972
skin/rabbit	lowest published toxic dose: 73 gm/kg/3W- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AIHAAP 34,526,1973

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.05 ppm (skin)	DTLVS* TLV/BEI,2013

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.05 ppm (0.34 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.05 ppm (0.3 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.05 ppm (0.34 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	ceiling concentration 0.02 ppm (0.2 mg/m³), skin, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.02 ppm (0.14 mg/m³), short term exposure limit 0.06 ppm (0.41 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 0.05 ppm (0.3 mg/m³), Skin, FEB2006
Occupational Exposure Limit-GERMANY	MAK 0.05 ppm (0.34 mg/m³), skin, 2011
Occupational Exposure Limit-ICELAND	short term exposure limit 0.02 ppm (0.2 mg/m³), skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 0.05 ppm (0.3 mg/m³), skin, 2006
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.05 ppm (0.34 mg/m³), skin, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 0,05 ppm (0,34 mg/m³), JUL2005
Occupational Exposure Limit-SWEDEN	time-weighted average 0.1 ppm (0.7 mg/m³);short term exposure limit 0.3 ppm (2 mg/m³), Skin, JUN2005
Occupational Exposure Limit-SWITZERLAND	ceiling concentration 0.05 ppm (0.35 mg/m³), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.3 mg/m³, Skin, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPYLENE GLYCOL DINITRATE-air	10H time-weighted average 0.05 ppm (Sk)	NIOSH* DHHS #92-100,1992

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health