Propane, 1-chloro-1-nitro-
RTECS #
TX5075000
CAS #
Updated
September 2013
Molecular Weight
123.55
Molecular Formula
C3H6ClNO2
Synonyms
1-Chloro-1-nitropropane (ACGIH:OSHA)
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| mutation in microorganisms | /Salmonella typhimurium | 333 µg/plate (+/-enzymatic activation step) | EMMUEG 19(Suppl 21),2,1992 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/guinea pig | Lowest published lethal concentration: 18 gm/m3/2H | Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage | JIHTAB 27,95,1945 |
| inhalation/mouse | lethal concentration (50 percent kill): 66 gm/m3/3H | Behavioral: General anesthetic Behavioral: Somnolence (general depressed activity) | HYSAAV 34(10-12),429,1969 |
| inhalation/rabbit | Lowest published lethal concentration: 2 gm/m3/6H | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Other changes | JIHTAB 27,95,1945 |
| oral/mouse | lethal dose (50 percent kill): 510 mg/kg | Behavioral: General anesthetic Behavioral: Somnolence (general depressed activity) | HYSAAV 34(10-12),429,1969 |
| oral/rabbit | lowest published lethal dose: 50 mg/kg | Vascular: Other changes Lung, Thorax, or Respiration: Other changes | JIHTAB 27,95,1945 |
| oral/rat | lowest published lethal dose: 50 mg/kg | 85JCAE -,596,1986 | |
| skin/mouse | Lethal dose: >5000 mL/kg | HYSAAV 34,429,1969 | |
| subcutaneous/mouse | lethal dose (50 percent kill): 165 mg/kg | Behavioral: General anesthetic Behavioral: Somnolence (general depressed activity) | HYSAAV 34(10-12),429,1969 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 2 ppm | DTLVS* TLV/BEI,2013 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 20 ppm (100 mg/m3) | DTLVS* 3,53,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 2 ppm (10 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 20 ppm (100 mg/m3), 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 2 ppm (10 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 2 ppm (10 mg/m3), MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 20 ppm (100 mg/m3), short term exposure limit 30 ppm (150 mg/m3), NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 2 ppm (10 mg/m3), FEB2006 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 2 ppm (10 mg/m3), NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 2 ppm (10 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 20 ppm (100 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 2 ppm (10 mg/m3), JAN2002 | |
| Occupational Exposure Limit-PERU | time-weighted average 2 ppm (10 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 50 mg/m3, JAN1999 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 2 ppm (10 mg/m3), JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 10 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 20 ppm (100 mg/m3), JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 20 ppm (100 mg/m3), JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 20 ppm (100 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 20 ppm (100 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 20 ppm (100 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 20 ppm (100 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1-CHLORO-1-NITROPROPANE-air | 10H time-weighted average 2 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Hazard Survey 1974 | Hazard Code 18590; Number of Industries 1; Total Number of Facilities 14; Number of Occupations 2; Total Number of Employees Exposed 721 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health