Propane, 1-butoxy-2,3-epoxy-

RTECS #

TX4200000

CAS #

2426-08-6
See: NMAM or OSHA Methods

Updated

December 2017

Molecular Weight

130.21

Molecular Formula

C₇H₁₄O₂

Synonyms

2,3-Epoxypropyl butyl ether
Ageflex BGE
BGE (OSHA)
Butyl glycidyl ether
Ether, butyl 2,3-epoxypropyl
Ether, butyl glycidyl
Glycidyl butyl ether
n-Butyl glycidyl ether
n-Butyl glycidyl ether (ACGIH:OSHA)
Oxirane, (butoxymethyl)- (9CI)
TK 10408

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	91 mg	mild	AMIHAB 14,250,1956
eye /rabbit	750 µg/24H	severe	85JCAE -,774,1986
skin /rabbit	454 mg/3D	mild	AMIHAB 14,250,1956
skin /rabbit	20 mg/24H	moderate	85JCAE -,774,1986

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
DNA Damage	/Escherichia coli	1 µmol/L	ARTODN 46,277,1980
micronucleus test	intraperitoneal/mouse	675 mg/kg	ENMUDM 2,521,1980
mutation in microorganisms	/Salmonella typhimurium	10 mg/plate (+/-enzymatic activation step)	MUREAV 66,367,1979
mutation in microorganisms	/Escherichia coli	20 µmol/L (-enzymatic activation step)	ARTODN 46,277,1980
other mutation test systems	/Escherichia coli	1 mmol/L	MUREAV 231,205,1990
sister chromatid exchange	lung/hamster	2500 µmol/L	MUREAV 249,55,1991

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
skin/mouse	36 gm/kg (24D male)	Reproductive: Effects on embryo or fetus: Fetal death	MUREAV 124,225,1983

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, leukemia cells	Inhibitor Concentration (5 percent kill): 5500 mg/L/30M	In Vitro Toxicity Studies: Cell counting	TIVIEQ 27,857,2013
In Vitro/Human, leukemia cells	Inhibitor Concentration Low: 776 mg/L/30M	In Vitro Toxicity Studies: Other assays	TIVIEQ 27,857,2013
In Vitro/Human, leukemia cells	Inhibitor Concentration (25 percent kill): 185.3 mg/L/24H	In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.	TIVIEQ 26,1150,2012
In Vitro/Human, lymphocyte	Inhibitor Concentration (30 percent kill): >200 mg/L/45H	In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.	TIVIEQ 29,901,2015
In Vitro/Human, lymphocyte	Inhibitor Concentration (50 percent kill): 149 mg/L/45H	In Vitro Toxicity Studies: Other assays	TIVIEQ 29,901,2015
In Vitro/Human, monocyte	Inhibitor Concentration Low: 2500 mg/L/2H	In Vitro Toxicity Studies: Other assays	TIVIEQ 27,1233,2013
In Vitro/Human, skin	Inhibitor Concentration (50 percent kill): 620.9 µmol/L/48H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 29,688,2015
In Vitro/Human, skin	Inhibitor Concentration (50 percent kill): 580.7 µmol/L/48H	In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc.	TIVIEQ 29,688,2015
In Vitro/Human, skin	Inhibitor Concentration (30 percent kill): 475.2 µmol/L/48H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 29,688,2015
In Vitro/Human, skin	Inhibitor Concentration (30 percent kill): 439.5 µmol/L/48H	In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc.	TIVIEQ 29,688,2015
In Vitro/Human, skin	Inhibitor Concentration Low: 50 pph/15M	In Vitro Toxicity Studies: Other assays	TIVIEQ 29,787,2015
In Vitro/Human, skin	Inhibitor Concentration (50 percent kill): 218.5 µmol/L/48H	In Vitro Toxicity Studies: Other assays	TXAPA9 245,281,2010
In Vitro/jrd	Inhibitor Concentration (50 percent kill): 4.22 mg/L/24H	In Vitro Toxicity Studies: Other assays	TIVIEQ 28,626,2014
inhalation/mouse	lethal concentration (50 percent kill): 260 mg/m³	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Respiratory depression	GISAAA 51(8),91,1986
inhalation/rat	lethal concentration (50 percent kill): 1030 ppm/8H	Eye: Lacrimation Gastrointestinal: Changes in structure or function of salivary glands Lung, Thorax, or Respiration: Dyspnea	AMIHAB 14,250,1956
intraperitoneal/mouse	lethal dose (50 percent kill): 700 mg/kg	Brain and Coverings: Recordings from specific areas of CNS Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia	AMIHAB 14,250,1956
intraperitoneal/rat	lethal dose (50 percent kill): 1140 mg/kg	Brain and Coverings: Recordings from specific areas of CNS Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia	AMIHAB 14,250,1956
oral/mouse	lethal dose (50 percent kill): 1530 mg/kg	Brain and Coverings: Recordings from specific areas of CNS Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia	AMIHAB 14,250,1956
oral/rat	lethal dose (50 percent kill): 1660 mg/kg	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Respiratory depression	GISAAA 51(8),91,1986
skin/rabbit	lethal dose (50 percent kill): 2520 µL/kg		AIHAAP 23,95,1962
skin/rat	lethal dose (50 percent kill): >2150 mg/kg		TSCAT* OTS0515483

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 3 ppm (skin, sen)	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		MUREAV 721,27,2011

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 50 ppm (270 mg/m³)	DTLVS* 3,33,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 25 ppm (133 mg/m³), JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 3 ppm (16.2 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 6 ppm (30 mg/m³), carc, MAY2011
Occupational Exposure Limit-FINLAND	short term exposure limit 25 ppm (140 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 25 ppm (135 mg/m³), C3 Carcinogen, FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 6 ppm (30 mg/m³), sen, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 25 ppm (135 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 25 ppm (135 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 25 ppm (133 mg/m³), sen, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 25 ppm (133 mg/m³), JUL2005
Occupational Exposure Limit-SWEDEN	time-weighted average 10 ppm (50 mg/m³);short term exposure limit 15 ppm (80 mg/m³), Sen, JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 25 ppm (135 mg/m³), KZG-week 50 ppm (270 mg/m³), skin, sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 135 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 50 ppm (270 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 50 ppm (270 mg/m³), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 50 ppm (270 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 50 ppm (270 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 50 ppm (270 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 50 ppm (270 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BUTYL GLYCIDYL ETHER-air	ceiling concentration 5.6 ppm/15M	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 14720; Number of Industries 56; Total Number of Facilities 2593; Number of Occupations 57; Total Number of Employees Exposed 60217; Total Number of Female Employees Exposed 14929
National Occupational Hazard Survey 1974	Hazard Code 14720; Number of Industries 37; Total Number of Facilities 1596; Number of Occupations 45; Total Number of Employees Exposed 19839

Status in Federal Agencies

Organization	Reference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE	FEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0293-8718;8EHQ-0892-9000
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: n-Butyl glycidyl ether, 1616
NIOSH CURRENT INTELLIGENCE BULLETIN 29, 1978

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health