CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Plumbane, tetraethyl -

RTECS #: TP4550000

CAS #: 78-00-2


UPDATE: May 2009 MW: 323.47 MF: C8H20Pb


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Czteroetylek olowiu (Polish)
  2. Lead, tetraethyl -
  3. NCI - C54988
  4. NSC 22314
  5. Piombo tetra - etile (Italian)
  6. RCRA waste number P110
  1. TEL
  2. Tetraethyl lead
  3. Tetraethyl lead (ACGIH:OSHA)
  4. Tetraethylolovo (Czech)
  5. Tetraethylplumbane
  6. Tetraethylplumbium


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
morphological transform hamster embryo 12,500 g/L AETODY 1,241,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 3 mg/kg (14 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic BNEOBV 58,41,1990
intraperitoneal
rat
lowest published toxic dose: 1,499 g/kg (13 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Hepatobiliary system
VHTODE 34,510,1992
intraperitoneal
rat
lowest published toxic dose: 3 mg/kg (19 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system
VHTODE 34,510,1992
oral
mouse
lowest published toxic dose: 11 mg/kg (5-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FCTXAV 13,629,1975
oral
rat
lowest published toxic dose: 11 mg/kg (6-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FCTXAV 13,629,1975
oral
rat
lowest published toxic dose: 7,500 g/kg (12-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TXAPA9 21,265,1972


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
subcutaneous
mouse
lowest published toxic dose: 100 mg/kg/21 day- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Lymphoma including Hodgkin's disease
EXPEAM 24,580,1968


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 1,749 gm/m3/30 minute Olfaction: Other olfaction effects

Eye: Lacrimation

Gastrointestinal: Nausea or vomiting
SAIGBL 17,223,1975
inhalation
mouse
lowest published lethal concentration: 650 mg/m3/7 hour N/R SAIGBL 15,3,1973
inhalation
mouse
lethal concentration (50 percent kill): 48.52 mg/m3/2 hour N/R TPKVAL 9,7,1967
inhalation
mouse
lethal concentration (50 percent kill): 3.5 ppm/2 hour N/R TPKVAL 9,7,1967
inhalation
rat
lethal concentration (50 percent kill): 850 mg/m3/1 hour Behavioral: Excitement

Lung, Thorax, or Respiration: Cyanosis
BJIMAG 18,277,1961
intraperitoneal
rat
lethal dose (50 percent kill): 15 mg/kg N/R MELAAD 54,486,1963
intravenous
rat
lethal dose (50 percent kill): 14,400 g/kg N/R MELAAD 54,486,1963
intravenous
rabbit
lowest published lethal dose: 22 mg/kg N/R EQSSDX 1,1,1975
oral
rat
lethal dose (50 percent kill): 12,300 g/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Aggression
EXPEAM 28,923,1972
oral
rabbit
lowest published lethal dose: 30 mg/kg N/R SAIGBL 15,3,1973
parenteral
rat
lethal dose (50 percent kill): 15 mg/kg N/R AOHYA3 3,226,1961
subcutaneous
mouse
lethal dose (50 percent kill): 13,020 g/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Convulsions or effect on seizure threshold
FKIZA4 49,2779,1958
subcutaneous
rabbit
lowest published lethal dose: 32 mg/kg N/R EQSSDX 1,1,1975
skin
dog
lowest published lethal dose: 547 mg/kg N/R SAIGBL 15,3,1973
skin
guinea pig
lowest published lethal dose: 995 mg/kg N/R SAIGBL 15,3,1973
skin
rabbit
lowest published lethal dose: 830 mg/kg N/R SAIGBL 15,3,1973
unreported route
man
lowest published lethal dose: 1,470 g/kg N/R 85DCAI 2,73,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 1,100 mg/m3/1 hour/5 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0533656-1
intravenous
monkey
lowest published toxic dose: 42 mg/kg/7 day- intermittent Behavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 2,187,1978
oral
mouse
lowest published toxic dose: 10 mg/kg/5 day- intermittent Behavioral: Tremor NTPTR* NTR-IMM-20009
oral
mouse
lowest published toxic dose: 14 mg/kg/14 day- intermittent Blood: Normocytic anemia

Blood: Luekopenia

Blood: Changes in erythrocyte (RBC) count
NTPTR* IMM-20009
oral
mouse
lowest published toxic dose: 14 mg/kg/14 day- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Renal function tests depressed

Immunological Including Allergic: Decrease in cellular immune response
NTPTR* IMM-20009
oral
mouse
lowest published toxic dose: 14 mg/kg/14 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Immunological Including Allergic: Decreased immune response
NTPTR* IMM-20009
oral
rat
lowest published toxic dose: 2,520 g/kg/6 week- continuous Endocrine: Other changes JANSY* 8,287,1983
skin
dog
lowest published toxic dose: 504 L/kg/21 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field FKIZA4 49,2779,1958


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg(Pb)/m3 (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMSUDL 7,230,1987
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 23,325,1980
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,230,1987
TOXICOLOGY REVIEW
JORCAI 76,265,1974
TOXICOLOGY REVIEW
JAMAAP 105,578,1935
TOXICOLOGY REVIEW
FCTXAV 9,105,1971
TOXICOLOGY REVIEW
AJMEAZ 38,409,1965
TOXICOLOGY REVIEW
85DHAX Pb,255,1972


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 mg(Pb)/m3 (skin) DTLVS* 3,251,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.075 mg(Pb)/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg(Pb)/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg(Pb)/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.075 mg(Pb)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg(Pb)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg(Pb)/m3, Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.007 ppm (0.05 mg(Pb)/m3), OCT 2002
Occupational Exposure Limit - FRANCE VME 0.1 mg(Pb)/m3, Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 0.05 mg(Pb)/m3, 2005
Occupational Exposure Limit - HUNGARY time-weighted average 0.05 mg/m3, short term exposure limit 0.2 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.075 mg(Pb)/m3, skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.075 mg/m3, skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.1 mg(Pb)/m3;
short term exposure limit 0.3 mg(Pb)/m3 (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.05 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg(Pb)/m3, skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.001 ppm (0.075 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.075 mg/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.05 mg/m3, MAC(short term exposure limit) 0.1 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.005 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.05 mg(Pb)/m3;
short term exposure limit 0.2 mg(Pb)/m3, Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 mg(Pb)/m3;
KZG- week 0.1 mg(Pb)/m3, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.075 mg/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRAETHYLLEAD (as Pb)-air 10 hour time-weighted average 0.075 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 71640;
Number of Industries 1;
Total Number of Facilities 85;
Number of Occupations 6;
Total Number of Employees Exposed 799
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 71640;
Number of Industries 6;
Total Number of Facilities 729;
Number of Occupations 15;
Total Number of Employees Exposed 36,802;
Total Number of Female Employees Exposed 1,099


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as component of anti-knock mixes for gas and as intermediate in making fungicides
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Tetraethyl lead (as Pb), 2533
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
AETODY Advances in Modern Environmental Toxicology. (Senate Press, Inc., P.O. Box 252, Princeton Junction, NJ 08550) V.1- 1980-
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
AOHYA3 Annals of Occupational Hygiene. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
BNEOBV Biology of the Neonate. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.15- 1970-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FKIZA4 Fukuoka Igaku Zasshi. (c/o Kyushu Daigaku Igakubu, Tatekasu, Fukuoka-shi, Fukuoka, Japan) V.33- 1940-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JANSY* Journal of the autonomic nervous system (Amsterdam, Elsevier/North Holland Biomedical Press) V.1-81 1979-2000.
JORCAI Journal of Organometallic Chemistry. (Elsevier Sequoia SA, POB 851, CH-1001 Lausanne l, Switzerland) V.1- 1963-
MELAAD Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8, 20122 Milan, Italy) V.16- 1925-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-

Used as component of anti-knock mixes for gas and as intermediate in making fungicides

NIOSH PROFILE (ORGANIC LEAD), SRC, 10/77

NIOSH PROFILE (PETROLEUM REFINING), FIRL, 4/78

RTECS Compound Description:
   Tumorigen
   Organometallic
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us