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Picric acid

RTECS #: TJ7875000

CAS #: 88-89-1


UPDATE: May 2009 MW: 229.12 MF: C6H3N3O7


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,3,5 - Trinitrophenol
  2. 2,4,6 - Trinitrofenol (Dutch)
  3. 2,4,6 - Trinitrofenolo (Italian)
  4. 2,4,6 - Trinitrophenol
  5. 2,4,6 - Trinitrophenyl (OSHA)
  6. 2 - Hydroxy - 1,3,5 - trinitrobenzene
  7. Acide picrique (French)
  8. Acido picrico (Italian)
  9. C.I. 10305
  10. Carbazotic acid
  1. Kyselina pikrova (Czech)
  2. Melinite
  3. Nitroxanthic acid
  4. Phenol trinitrate
  5. Phenol, 2,4,6 - trinitro -
  6. Picric acid (ACGIH:OSHA)
  7. Picronitric acid
  8. Pikrinezuur (Dutch)
  9. Pikrinsaeure (German)
  10. Pikrynowy kwas (Polish)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Escherichia coli 1,800 ppm (-enzymatic activation step) MUREAV 47,75,1978
mutation in microorganisms Salmonella typhimurium 5 µmol/plate (+/-enzymatic activation step) MUREAV 90,91,1981
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
1,250 µmol/L MUREAV 90,91,1981
sex chromosome loss and nondisjunction parenteral
Drosophila melanogaster
1,500 ppm ENMUDM 7,677,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 56,300 µg/kg Behavioral: Convulsions or effect on seizure threshold NYKZAU 56,450,1960
oral
cat
lowest published lethal dose: 250 mg/kg N/R HBAMAK 4,1289,1935
oral
cat
lethal dose (50 percent kill): 500 mg/kg N/R ENTOX* -,438,2005
oral
guinea pig
lowest published lethal dose: 100 mg/kg N/R HBAMAK 4,1289,1935
oral
guinea pig
lethal dose (50 percent kill): 100 mg/kg N/R ENTOX* -,438,2005
oral
rat
lethal dose (50 percent kill): 200 mg/kg Eye: Chromodacryorrhea

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
JTEHD6 37,313,1992
oral
rat
lethal dose (50 percent kill): 200 mg/kg N/R ENTOX* -,438,2005
oral
rabbit
lowest published lethal dose: 120 mg/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Body temperature increase
XPHBAO 271,151,1941
oral
rabbit
lethal dose (50 percent kill): 120 mg/kg N/R ENTOX* -,438,2005
subcutaneous
dog
lowest published lethal dose: 60 mg/kg N/R HBAMAK 4,1289,1935
subcutaneous
pigeon
lowest published lethal dose: 200 mg/kg N/R HBAMAK 4,1289,1935
unreported route
dog
lowest published lethal dose: 60 mg/kg Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes
XPHBAO 271,151,1941


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 47,75,1978
TOXICOLOGY REVIEW
ENTOX* -,438,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 mg/m3 (skin) DTLVS* 3,212,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg/m3, OCT 2002
Occupational Exposure Limit - EC time-weighted average 0.1 mg/m3
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg/m3, Skin, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg/m3, short term exposure limit 0.1 mg/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.1 mg/m3;
short term exposure limit 0.3 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.1 mg/m3, MAC(short term exposure limit) 0.3 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3,KZG- week 0.1 mg/m3, Skin, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg/m3;
short term exposure limit 0.3 mg/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 mg/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PICRIC ACID-air time-weighted average 0.1 mg/m3 (Sk);
short term exposure limit 0.3 mg/m3 (Sk)
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 59450;
Number of Industries 17;
Total Number of Facilities 2,097;
Number of Occupations 14;
Total Number of Employees Exposed 21,627
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 59450;
Number of Industries 20;
Total Number of Facilities 2,224;
Number of Occupations 26;
Total Number of Employees Exposed 37,003;
Total Number of Female Employees Exposed 21,627


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in synthesis of dye intermediates and in manufacturing picrates
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)

Used in synthesis of dye intermediates and in manufacturing picrates

NIOSH PROFILE (NITROPHENOLS), SRC, 4/81

RTECS Compound Description:
   Mutagen

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